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Mpv17l Mpv17 transgene, kidney disease mutant-like [ Mus musculus (house mouse) ]

Gene ID: 93734, updated on 23-Jun-2021

Summary

Official Symbol
Mpv17lprovided by MGI
Official Full Name
Mpv17 transgene, kidney disease mutant-likeprovided by MGI
Primary source
MGI:MGI:2135951
See related
Ensembl:ENSMUSG00000022679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M-; M-LP
Expression
Biased expression in kidney adult (RPKM 40.0), cortex adult (RPKM 5.6) and 3 other tissues See more
Orthologs
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Genomic context

See Mpv17l in Genome Data Viewer
Location:
16; 16 A1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (13721025..13767483)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (13903161..13949619)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (13940788..13949450)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene N-terminal Asn amidase Neighboring gene pyridoxal-dependent decarboxylase domain containing 1 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene Neighboring gene laminin, gamma 1 pseudogene Neighboring gene interferon induced transmembrane protein 7 Neighboring gene bMERB domain containing 1 Neighboring gene aldo-keto reductase family 1, member B8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289561.1NP_001276490.1  mpv17-like protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice in the 3' coding region which results in a frameshift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC107769
    Consensus CDS
    CCDS79425.1
    UniProtKB/TrEMBL
    D3Z6M3
    Related
    ENSMUSP00000116147.2, ENSMUST00000143697.8
  2. NM_001289562.1NP_001276491.1  mpv17-like protein isoform 3

    See identical proteins and their annotated locations for NP_001276491.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC107769, AK136449
    Consensus CDS
    CCDS79423.1
    UniProtKB/Swiss-Prot
    Q99MS3
    Related
    ENSMUSP00000120169.2, ENSMUST00000128757.8
    Conserved Domains (1) summary
    pfam04117
    Location:968
    Mpv17_PMP22; Mpv17 / PMP22 family
  3. NM_001289563.1NP_001276492.1  mpv17-like protein isoform 4

    See identical proteins and their annotated locations for NP_001276492.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4, 5 and 6 encode the same isoform (4).
    Source sequence(s)
    AC107769, AK144372
    Consensus CDS
    CCDS79426.1
    UniProtKB/Swiss-Prot
    Q99MS3
    Related
    ENSMUSP00000123424.2, ENSMUST00000141971.8
    Conserved Domains (1) summary
    pfam04117
    Location:261
    Mpv17_PMP22; Mpv17 / PMP22 family
  4. NM_001289565.1NP_001276494.1  mpv17-like protein isoform 4

    See identical proteins and their annotated locations for NP_001276494.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4, 5 and 6 encode the same isoform (4).
    Source sequence(s)
    AC107769
    Consensus CDS
    CCDS79426.1
    UniProtKB/Swiss-Prot
    Q99MS3
    Related
    ENSMUSP00000117826.3, ENSMUST00000124947.8
    Conserved Domains (1) summary
    pfam04117
    Location:261
    Mpv17_PMP22; Mpv17 / PMP22 family
  5. NM_001289567.1NP_001276496.1  mpv17-like protein isoform 4

    See identical proteins and their annotated locations for NP_001276496.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4, 5 and 6 encode the same isoform (4).
    Source sequence(s)
    AC107769, BB618586
    Consensus CDS
    CCDS79426.1
    UniProtKB/Swiss-Prot
    Q99MS3
    Conserved Domains (1) summary
    pfam04117
    Location:261
    Mpv17_PMP22; Mpv17 / PMP22 family
  6. NM_033564.3NP_291042.2  mpv17-like protein isoform 1

    See identical proteins and their annotated locations for NP_291042.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the logest isoform (1).
    Source sequence(s)
    AC107769, AF305634
    Consensus CDS
    CCDS27970.1
    UniProtKB/Swiss-Prot
    Q99MS3
    Related
    ENSMUSP00000023360.8, ENSMUST00000023360.14
    Conserved Domains (1) summary
    pfam04117
    Location:107166
    Mpv17_PMP22; Mpv17 / PMP22 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    13721025..13767483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249342.1XP_030105202.1  mpv17-like protein isoform X1

    Conserved Domains (1) summary
    pfam04117
    Location:261
    Mpv17_PMP22; Mpv17 / PMP22 family
  2. XM_036160190.1XP_036016083.1  mpv17-like protein isoform X1

    Conserved Domains (1) summary
    pfam04117
    Location:261
    Mpv17_PMP22; Mpv17 / PMP22 family
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