U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mpv17l Mpv17 transgene, kidney disease mutant-like [ Mus musculus (house mouse) ]

Gene ID: 93734, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Mpv17lprovided by MGI
Official Full Name
Mpv17 transgene, kidney disease mutant-likeprovided by MGI
Primary source
MGI:MGI:2135951
See related
Ensembl:ENSMUSG00000022679 AllianceGenome:MGI:2135951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M-LP
Summary
Predicted to be involved in negative regulation of hydrogen peroxide biosynthetic process; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; and reactive oxygen species metabolic process. Located in mitochondrion. Orthologous to human MPV17L (MPV17 mitochondrial inner membrane protein like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 40.0), cortex adult (RPKM 5.6) and 3 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
16 A1; 16 9.64 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (13721025..13767483)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (13903161..13949619)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene N-terminal Asn amidase Neighboring gene pyridoxal-dependent decarboxylase domain containing 1 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40163 Neighboring gene STARR-positive B cell enhancer ABC_E8619 Neighboring gene STARR-seq mESC enhancer starr_40164 Neighboring gene laminin, gamma 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40165 Neighboring gene STARR-seq mESC enhancer starr_40166 Neighboring gene STARR-seq mESC enhancer starr_40168 Neighboring gene STARR-seq mESC enhancer starr_40169 Neighboring gene STARR-seq mESC enhancer starr_40170 Neighboring gene interferon induced transmembrane protein 7 Neighboring gene bMERB domain containing 1 Neighboring gene aldo-keto reductase family 1, member B8 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Deficiency of M-LP/Mpv17L leads to development of β-cell hyperplasia and improved glucose tolerance via activation of the Wnt and TGF-β pathways. Iida R, et al. Biochim Biophys Acta Mol Basis Dis, 2022 Mar 1. PMID 34883249
  2. A novel alternative spliced Mpv17-like protein isoform localizes in cytosol and is expressed in a kidney- and adult-specific manner. Iida R, et al. Exp Cell Res, 2005 Jan 1. PMID 15541722
  3. Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease. Krick S, et al. Proc Natl Acad Sci U S A, 2008 Sep 16. PMID 18772386, Free PMC Article
  4. Cloning, mapping, genomic organization, and expression of mouse M-LP, a new member of the peroxisomal membrane protein Mpv17 domain family. Iida R, et al. Biochem Biophys Res Commun, 2001 May 4. PMID 11327696
  5. M-LP, Mpv17-like protein, has a peroxisomal membrane targeting signal comprising a transmembrane domain and a positively charged loop and up-regulates expression of the manganese superoxide dismutase gene. Iida R, et al. J Biol Chem, 2003 Feb 21. PMID 12471025

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockout of M-LP/Mpv17L, a newly identified atypical PDE, induces physiological afferent cardiac hypertrophy in mice.
    Title: Knockout of M-LP/Mpv17L, a newly identified atypical PDE, induces physiological afferent cardiac hypertrophy in mice.
  2. Deficiency of M-LP/Mpv17L leads to development of beta-cell hyperplasia and improved glucose tolerance via activation of the Wnt and TGF-beta pathways.
    Title: Deficiency of M-LP/Mpv17L leads to development of β-cell hyperplasia and improved glucose tolerance via activation of the Wnt and TGF-β pathways.
  3. identify Mpv17l as a unique interacting protein and regulator of HtrA2 protease mediating antioxidant and antiapoptotic function in mitochondria
    Title: Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease.
  4. participates in reactive oxygen species metabolism
    Title: M-LP, Mpv17-like protein, has a peroxisomal membrane targeting signal comprising a transmembrane domain and a positively charged loop and up-regulates expression of the manganese superoxide dismutase gene.
  5. In mice, M-LPs is expressed exclusively in kidneys after 6 weeks. Transfection with M-LPS up-regulates SOD2 and down-regulates cellular glutathione peroxidase (Gpx1) and plasma glutathione peroxidase (Gpx3) gene expression
    Title: A novel alternative spliced Mpv17-like protein isoform localizes in cytosol and is expressed in a kidney- and adult-specific manner.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
mpv17-like protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289561.1 → NP_001276490.1  mpv17-like protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice in the 3' coding region which results in a frameshift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC107769
    Consensus CDS
    CCDS79425.1
    UniProtKB/TrEMBL
    D3Z6M3
    Related
    ENSMUSP00000116147.2, ENSMUST00000143697.8

  2. NM_001289562.1 → NP_001276491.1  mpv17-like protein isoform 3

    See identical proteins and their annotated locations for NP_001276491.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC107769, AK136449
    Consensus CDS
    CCDS79423.1
    UniProtKB/TrEMBL
    E9Q4P9
    Related
    ENSMUSP00000120169.2, ENSMUST00000128757.8
    Conserved Domains (1) summary
    pfam04117
    Location:9 → 68
    Mpv17_PMP22; Mpv17 / PMP22 family

  3. NM_001289563.1 → NP_001276492.1  mpv17-like protein isoform 4

    See identical proteins and their annotated locations for NP_001276492.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4, 5 and 6 encode the same isoform (4).
    Source sequence(s)
    AC107769, AK144372
    Consensus CDS
    CCDS79426.1
    UniProtKB/TrEMBL
    E9Q4P9
    Related
    ENSMUSP00000123424.2, ENSMUST00000141971.8
    Conserved Domains (1) summary
    pfam04117
    Location:2 → 61
    Mpv17_PMP22; Mpv17 / PMP22 family

  4. NM_001289565.1 → NP_001276494.1  mpv17-like protein isoform 4

    See identical proteins and their annotated locations for NP_001276494.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4, 5 and 6 encode the same isoform (4).
    Source sequence(s)
    AC107769
    Consensus CDS
    CCDS79426.1
    UniProtKB/TrEMBL
    E9Q4P9
    Related
    ENSMUSP00000117826.3, ENSMUST00000124947.8
    Conserved Domains (1) summary
    pfam04117
    Location:2 → 61
    Mpv17_PMP22; Mpv17 / PMP22 family

  5. NM_001289567.1 → NP_001276496.1  mpv17-like protein isoform 4

    See identical proteins and their annotated locations for NP_001276496.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4, 5 and 6 encode the same isoform (4).
    Source sequence(s)
    AC107769, BB618586
    Consensus CDS
    CCDS79426.1
    UniProtKB/TrEMBL
    E9Q4P9
    Conserved Domains (1) summary
    pfam04117
    Location:2 → 61
    Mpv17_PMP22; Mpv17 / PMP22 family

  6. NM_033564.3 → NP_291042.2  mpv17-like protein isoform 1

    See identical proteins and their annotated locations for NP_291042.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the logest isoform (1).
    Source sequence(s)
    AC107769, AF305634
    Consensus CDS
    CCDS27970.1
    UniProtKB/Swiss-Prot
    Q3UWD2, Q8CI14, Q99MS3
    Related
    ENSMUSP00000023360.8, ENSMUST00000023360.14
    Conserved Domains (1) summary
    pfam04117
    Location:107 → 166
    Mpv17_PMP22; Mpv17 / PMP22 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    13721025..13767483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249342.1 → XP_030105202.1  mpv17-like protein isoform X1

    UniProtKB/TrEMBL
    E9Q4P9
    Conserved Domains (1) summary
    pfam04117
    Location:2 → 61
    Mpv17_PMP22; Mpv17 / PMP22 family

  2. XM_036160190.1 → XP_036016083.1  mpv17-like protein isoform X1

    UniProtKB/TrEMBL
    E9Q4P9
    Conserved Domains (1) summary
    pfam04117
    Location:2 → 61
    Mpv17_PMP22; Mpv17 / PMP22 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MS3.2 GenPept UniProtKB/Swiss-Prot:Q99MS3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous