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sinR master regulator of biofilm formation [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 938544, updated on 4-Feb-2024

Summary

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Gene symbol
sinR
Gene description
master regulator of biofilm formation
Locus tag
BSU_24610
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU24610
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Genomic context

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Sequence:
NC_000964.3 (2552653..2552988)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene antagonist of SinR Neighboring gene major biofilm matrix component Neighboring gene type I signal peptidase Neighboring gene lipoprotein for biofilm formation

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Site-directed mutagenesis of the quorum-sensing transcriptional regulator SinR affects the biosynthesis of menaquinone in Bacillus subtilis. Wu J, et al. Microb Cell Fact, 2021 Jun 7. PMID 34098969, Free PMC Article
  2. Targets of the master regulator of biofilm formation in Bacillus subtilis. Chu F, et al. Mol Microbiol, 2006 Feb. PMID 16430695
  3. Biofilm formation by Bacillus subtilis requires an endoribonuclease-containing multisubunit complex that controls mRNA levels for the matrix gene repressor SinR. DeLoughery A, et al. Mol Microbiol, 2016 Jan. PMID 26434553, Free PMC Article
  4. Effects of phosphorelay perturbations on architecture, sporulation, and spore resistance in biofilms of Bacillus subtilis. Veening JW, et al. J Bacteriol, 2006 Apr. PMID 16585769, Free PMC Article
  5. A master regulator for biofilm formation by Bacillus subtilis. Kearns DB, et al. Mol Microbiol, 2005 Feb. PMID 15661000

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Site-directed mutagenesis of the quorum-sensing transcriptional regulator SinR affects the biosynthesis of menaquinone in Bacillus subtilis.
    Title: Site-directed mutagenesis of the quorum-sensing transcriptional regulator SinR affects the biosynthesis of menaquinone in Bacillus subtilis.
  2. Biofilm formation requires an endoribonuclease-containing complex that controls mRNA levels for the matrix gene repressor SinR.
    Title: Biofilm formation by Bacillus subtilis requires an endoribonuclease-containing multisubunit complex that controls mRNA levels for the matrix gene repressor SinR.
  3. An electrophoretic mobility shift assay (EMSA) showed that SinR bound to the degU promoter and that SlrR formed a complex with SinR on the degU promoter.
    Title: Regulation of the response regulator gene degU through the binding of SinR/SlrR and exclusion of SinR/SlrR by DegU in Bacillus subtilis.
  4. SinR is a master regulator for biofilm formation and its principal biological function is to govern the assembly of complex multicellular communities.
    Title: Targets of the master regulator of biofilm formation in Bacillus subtilis.
  5. we demonstrate that overproduction of the phosphorelay components KinA and Spo0A stimulates cell bundle formation in biofilms, while overproduction of the transition state regulators AbrB and SinR leads to repression of formation of elevated bundles.
    Title: Effects of phosphorelay perturbations on architecture, sporulation, and spore resistance in biofilms of Bacillus subtilis.
  6. master regulator for biofilm formation by repressing transcription of exopolysaccharide operon
    Title: A master regulator for biofilm formation by Bacillus subtilis.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
master regulator of biofilm formation
NP_390341.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_390341.1 master regulator of biofilm formation [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_390341.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A086W106, A0A0M0L4V7, D4FYP9
    Conserved Domains (2) summary
    cd00093
    Location:3 → 61
    HTH_XRE; Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.
    pfam08671
    Location:74 → 101
    SinI; Anti-repressor SinI
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
3ZKC_A.1
3ZKC_B.1
P06533.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases