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Pcdhb5 protocadherin beta 5 [ Mus musculus (house mouse) ]

Gene ID: 93876, updated on 11-Apr-2024

Summary

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Official Symbol
Pcdhb5provided by MGI
Official Full Name
protocadherin beta 5provided by MGI
Primary source
MGI:MGI:2136739
See related
Ensembl:ENSMUSG00000063687 AllianceGenome:MGI:2136739
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PcdhbE; Pcdhb4A
Summary
Predicted to be involved in cell adhesion. Predicted to be integral component of plasma membrane. Is expressed in central nervous system and retina. Orthologous to human PCDHB4 (protocadherin beta 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
18 B3; 18 19.47 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (37453434..37456966)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37320381..37323913)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protocadherin alpha 4B Neighboring gene predicted gene, 38666 Neighboring gene predicted gene, 38667 Neighboring gene RAD18 homolog pseudogene Neighboring gene protocadherin beta 4 Neighboring gene protocadherin beta 6 Neighboring gene protocadherin beta 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting. Hasegawa S, et al. Front Mol Neurosci, 2016. PMID 28066179, Free PMC Article
  2. Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system. Junghans D, et al. Eur J Neurosci, 2008 Feb. PMID 18279309
  3. The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. Vanhalst K, et al. FEBS Lett, 2001 Apr 20. PMID 11322959
  4. Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Gendrel AV, et al. Mol Cell Biol, 2013 Aug. PMID 23754746, Free PMC Article
  5. CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons. Elbert A, et al. J Neurosci, 2019 Jan 2. PMID 30377227, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protocadherin beta 5
Names
Protocadherin-betaE
cell-cell adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053130.3 → NP_444360.1  protocadherin beta 5 precursor

    See identical proteins and their annotated locations for NP_444360.1

    Status: VALIDATED

    Source sequence(s)
    AK028661, AK049825
    Consensus CDS
    CCDS29173.1
    UniProtKB/TrEMBL
    Q8CEA8, Q91XZ5
    Related
    ENSMUSP00000077389.3, ENSMUST00000078271.4
    Conserved Domains (3) summary
    cd11304
    Location:245 → 342
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:29 → 111
    Cadherin_2; Cadherin-like
    pfam16492
    Location:687 → 769
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    37453434..37456966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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