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Pcdhb8 protocadherin beta 8 [ Mus musculus (house mouse) ]

Gene ID: 93879, updated on 11-Apr-2024

Summary

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Official Symbol
Pcdhb8provided by MGI
Official Full Name
protocadherin beta 8provided by MGI
Primary source
MGI:MGI:2136742
See related
Ensembl:ENSMUSG00000045876 AllianceGenome:MGI:2136742
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PcdhbH; Pcdhb5C
Summary
Enables calcium ion binding activity and identical protein binding activity. Predicted to be involved in cell adhesion. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in metanephros; nervous system; and retina. Orthologous to human PCDHB5 (protocadherin beta 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
18 B3; 18 19.47 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (37488324..37490663)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37355271..37357610)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protocadherin alpha 4B Neighboring gene predicted gene, 38666 Neighboring gene predicted gene, 38667 Neighboring gene protocadherin beta 6 Neighboring gene protocadherin beta 7 Neighboring gene protocadherin beta 10 Neighboring gene protocadherin beta 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins. Goodman KM, et al. Neuron, 2016 May 18. PMID 27161523, Free PMC Article
  2. Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor. Dallosso AR, et al. PLoS Genet, 2009 Nov. PMID 19956686, Free PMC Article
  3. Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system. Junghans D, et al. Eur J Neurosci, 2008 Feb. PMID 18279309
  4. Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity. Toyoda S, et al. Neuron, 2014 Apr 2. PMID 24698270
  5. Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice. Xu L, et al. Sci Adv, 2021 Jan. PMID 33523829, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protocadherin beta-8
Names
PCDH-beta-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053133.1 → NP_444363.1  protocadherin beta-8 precursor

    See identical proteins and their annotated locations for NP_444363.1

    Status: PROVISIONAL

    Source sequence(s)
    AY013790
    Consensus CDS
    CCDS29175.1
    UniProtKB/Swiss-Prot
    Q91XZ2
    UniProtKB/TrEMBL
    A8E4K7
    Related
    ENSMUSP00000054371.2, ENSMUST00000051163.3
    Conserved Domains (3) summary
    cd11304
    Location:247 → 342
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:31 → 112
    Cadherin_2; Cadherin-like
    pfam16492
    Location:686 → 766
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    37488324..37490663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XZ2.1 GenPept UniProtKB/Swiss-Prot:Q91XZ2

Gene LinkOut

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