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Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 94173, updated on 11-Apr-2024

Summary

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Official Symbol
Idh3bprovided by RGD
Official Full Name
isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit betaprovided by RGD
Primary source
RGD:621881
See related
Ensembl:ENSRNOG00000007316 AllianceGenome:RGD:621881
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables isocitrate dehydrogenase (NAD+) activity. Involved in NADH metabolic process; carboxylic acid metabolic process; and tricarboxylic acid cycle. Predicted to be part of mitochondrial isocitrate dehydrogenase complex (NAD+). Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in retinitis pigmentosa 46. Orthologous to human IDH3B (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1719.4), Muscle (RPKM 1296.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Idh3b in Genome Data Viewer
Location:
3q36
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (137934971..137940275, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117481845..117486909, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (122808564..122813638, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene NOP56 ribonucleoprotein Neighboring gene small nucleolar RNA SNORD56 Neighboring gene small nucleolar RNA, C/D box 57 Neighboring gene ribosomal protein L31-like 6 Neighboring gene ribosomal protein S12-like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of NAD(+)-dependent isocitrate dehydrogenase in brown adipose tissue. Shinohara Y, et al. Biochem Biophys Res Commun, 2001 Mar 2. PMID 11237704
  2. Preparation and properties of mitochondria derived from synaptosomes. Lai JC, et al. Biochem J, 1976 Feb 15. PMID 938457, Free PMC Article
  3. Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. Soundar S, et al. J Biol Chem, 2003 Dec 26. PMID 14555658
  4. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article
  5. Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart. Martins-Marques T, et al. Mol Cell Proteomics, 2015 Nov. PMID 26316108, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94111

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in isocitrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of isocitrate dehydrogenase complex (NAD+) ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Names
NAD(+)-specific ICDH subunit beta
NAD+-specific isocitrate dehydrogenase b subunit
isocitrate dehydrogenase (NAD(+)) 3 beta
isocitrate dehydrogenase 3 (NAD+) beta
isocitric dehydrogenase subunit beta
NP_446033.1
XP_006235110.1
XP_063140819.1
XP_063140820.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053581.1 → NP_446033.1  isocitrate dehydrogenase [NAD] subunit beta, mitochondrial precursor

    See identical proteins and their annotated locations for NP_446033.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079113
    UniProtKB/Swiss-Prot
    Q68FX0
    UniProtKB/TrEMBL
    A6HQ80
    Related
    ENSRNOP00000009681.4, ENSRNOT00000009681.7
    Conserved Domains (1) summary
    cl00445
    Location:47 → 380
    Iso_dh; Isocitrate/isopropylmalate dehydrogenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    137934971..137940275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235048.5 → XP_006235110.1  isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl00445
    Location:47 → 377
    Iso_dh; Isocitrate/isopropylmalate dehydrogenase

  2. XM_063284749.1 → XP_063140819.1  isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I6AMM2

  3. XM_063284750.1 → XP_063140820.1  isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FX0.1 GenPept UniProtKB/Swiss-Prot:Q68FX0

Gene LinkOut

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