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Nans N-acetylneuraminic acid synthase (sialic acid synthase) [ Mus musculus (house mouse) ]

Gene ID: 94181, updated on 5-Jan-2022

Summary

Official Symbol
Nansprovided by MGI
Official Full Name
N-acetylneuraminic acid synthase (sialic acid synthase)provided by MGI
Primary source
MGI:MGI:2149820
See related
Ensembl:ENSMUSG00000028334
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sas; BB056474; 4632418E04Rik
Summary
Enables N-acylneuraminate-9-phosphate synthase activity. Predicted to be involved in glycosylation. Located in cytosol. Is expressed in several structures, including alimentary system; sensory organ; skeleton; skin; and tarsus. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Genevieve-type. Orthologous to human NANS (N-acetylneuraminate synthase). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in colon adult (RPKM 145.1), genital fat pad adult (RPKM 46.1) and 21 other tissues See more
Orthologs
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Genomic context

See Nans in Genome Data Viewer
Location:
4; 4 B1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46489255..46503440)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46489329..46503438)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (46502201..46516310)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene hemogen Neighboring gene acidic (leucine-rich) nuclear phosphoprotein 32 family, member B Neighboring gene predicted gene, 22247 Neighboring gene tripartite motif-containing 14 Neighboring gene predicted gene, 54223 Neighboring gene predicted gene, 16731 Neighboring gene coronin, actin binding protein 2A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acylneuraminate-9-phosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables N-acylneuraminate-9-phosphate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carbohydrate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sialic acid synthase
Names
N-acetylneuraminate-9-phosphate synthase
N-acetylneuraminic acid 9-phosphate synthetase
N-acetylneuraminic acid phosphate synthase
NP_444409.1
XP_036020474.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053179.3NP_444409.1  sialic acid synthase

    See identical proteins and their annotated locations for NP_444409.1

    Status: PROVISIONAL

    Source sequence(s)
    AK076290
    Consensus CDS
    CCDS18152.1
    UniProtKB/Swiss-Prot
    Q99J77
    Related
    ENSMUSP00000030018.5, ENSMUST00000030018.5
    Conserved Domains (2) summary
    cd11615
    Location:292348
    SAF_NeuB_like; C-terminal SAF domain of sialic acid synthetase
    pfam03102
    Location:40278
    NeuB; NeuB family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    46489255..46503440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164581.1XP_036020474.1  sialic acid synthase isoform X1

    Conserved Domains (1) summary
    pfam03102
    Location:40278
    NeuB; NeuB family
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