Cox5b cytochrome c oxidase subunit 5B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cox5bprovided by RGD
Official Full Name: cytochrome c oxidase subunit 5Bprovided by RGD
Primary source: RGD:620608
See related: Ensembl:ENSRNOG00000016660 AllianceGenome:RGD:620608
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytochrome-c oxidase activity. Involved in response to peptide hormone. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial respiratory chain complex IV. Biomarker of hypertension. Orthologous to human COX5B (cytochrome c oxidase subunit 5B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 6855.5), Muscle (RPKM 4494.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (46417735..46419664)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (38921980..38923806)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (43259706..43262039)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased Tissue COX5B Expression is associated with Mitochondrial Dysfunction during Sepsis-Induced Kidney Injury
Title: Decreased Tissue COX5B Expression and Mitochondrial Dysfunction during Sepsis-Induced Kidney Injury in Rats.
Report loss of Cox5b subunits in ischemia-reperfusion injury and exacerbation of subunit loss by PKC-epsilon inhibition.
Title: Differential loss of cytochrome-c oxidase subunits in ischemia-reperfusion injury: exacerbation of COI subunit loss by PKC-epsilon inhibition.
In liver, T3 thyroid hormone induced a coordinated increase in the expression of the nuclear COX Vb
Title: Tissue-specific regulation of cytochrome c oxidase subunit expression by thyroid hormone.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cox5b (e-PCR), detects polymorphism
- UniSTS:531500

PMC195978P2 (e-PCR)
- UniSTS:271789

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytochrome-c oxidase activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, cytochrome c to oxygen	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex IV	IEA Inferred from Electronic Annotation more info
part_of mitochondrial respiratory chain complex IV	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome c oxidase subunit 5B, mitochondrial

Names: cytochrome c oxidase polypeptide Vb; cytochrome c oxidase subunit VIA*; cytochrome c oxidase subunit Vb

NP_446038.1

EC 7.1.1.9

XP_063123859.1

EC 7.1.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053586.2 → NP_446038.1 cytochrome c oxidase subunit 5B, mitochondrial precursor

See identical proteins and their annotated locations for NP_446038.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

P12075

UniProtKB/TrEMBL

A0A8L2QBW2, A6INE7

Related

ENSRNOP00000022487.3, ENSRNOT00000022487.6

Conserved Domains (1) summary

cd00924
Location:32 → 124

Cyt_c_Oxidase_Vb; Cytochrome c oxidase subunit Vb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...