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Slc4a10 solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 [ Mus musculus (house mouse) ]

Gene ID: 94229, updated on 9-Oct-2021

Summary

Official Symbol
Slc4a10provided by MGI
Official Full Name
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10provided by MGI
Primary source
MGI:MGI:2150150
See related
Ensembl:ENSMUSG00000026904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NCB; NCBE; mKIAA4136
Expression
Biased expression in frontal lobe adult (RPKM 22.9), cortex adult (RPKM 20.5) and 4 other tissues See more
Orthologs
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Genomic context

See Slc4a10 in Genome Data Viewer
Location:
2; 2 C1.3
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (61876815..62157087)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (62046472..62326743)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (61884597..62164800)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene zinc finger protein 277 pseudogene Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene dipeptidylpeptidase 4 Neighboring gene predicted gene 13561

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4136

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables anion:anion antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables inorganic anion exchanger activity IEA
Inferred from Electronic Annotation
more info
 
enables sodium:bicarbonate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium:bicarbonate symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium:bicarbonate symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in anion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within brain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within locomotory exploration behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein glycosylation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within proton transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pyramidal neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cellular pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of pH IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of short-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to light stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in visual perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in CA3 pyramidal cell dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in basal dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane ISA
Inferred from Sequence Alignment
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in somatodendritic compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sodium-driven chloride bicarbonate exchanger
Names
sodium bicarbonate cotransporter NBCn2-E
sodium bicarbonate cotransporter member 10 variant NBCn2-E'

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242378.1NP_001229307.1  sodium-driven chloride bicarbonate exchanger isoform 1

    See identical proteins and their annotated locations for NP_001229307.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK043017, AL928804, BP758238, CF746204, HQ533147
    UniProtKB/TrEMBL
    F1DFN1, Q8C943, R4H243
    Conserved Domains (3) summary
    TIGR00834
    Location:1181061
    ae; anion exchange protein
    pfam00955
    Location:476989
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:146435
    Band_3_cyto; Band 3 cytoplasmic domain
  2. NM_001242379.1NP_001229308.1  sodium-driven chloride bicarbonate exchanger isoform 3

    See identical proteins and their annotated locations for NP_001229308.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AK043017, AL928804, BP758238, CF746204
    Consensus CDS
    CCDS57173.1
    UniProtKB/TrEMBL
    B1AWV9, Q8C943
    Related
    ENSMUSP00000061411.9, ENSMUST00000054484.15
    Conserved Domains (3) summary
    TIGR00834
    Location:1181031
    ae; anion exchange protein
    pfam00955
    Location:446959
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:146405
    Band_3_cyto; Band 3 cytoplasmic domain
  3. NM_001242380.1NP_001229309.1  sodium-driven chloride bicarbonate exchanger isoform 4

    See identical proteins and their annotated locations for NP_001229309.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK043017, AL928613, AL928804, BP758238, CF746204, DN176790
    Consensus CDS
    CCDS57172.1
    UniProtKB/Swiss-Prot
    Q5DTL9
    UniProtKB/TrEMBL
    Q8C943
    Related
    ENSMUSP00000108099.3, ENSMUST00000112480.3
    Conserved Domains (3) summary
    TIGR00834
    Location:1181061
    ae; anion exchange protein
    pfam00955
    Location:476989
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:146435
    Band_3_cyto; Band 3 cytoplasmic domain
  4. NM_001242381.1NP_001229310.1  sodium-driven chloride bicarbonate exchanger isoform 5

    See identical proteins and their annotated locations for NP_001229310.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction at the 5' end of an exon, lacks an alternate in-frame exon, and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) lacks two alternate internal segments and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL928804, BP758238, CF746204, DN176790, HQ533147
    UniProtKB/Swiss-Prot
    Q5DTL9
    UniProtKB/TrEMBL
    R4H243
    Conserved Domains (3) summary
    TIGR00834
    Location:1181030
    ae; anion exchange protein
    pfam00955
    Location:445958
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:146404
    Band_3_cyto; Band 3 cytoplasmic domain
  5. NM_001242382.1NP_001229311.1  sodium-driven chloride bicarbonate exchanger isoform 6

    See identical proteins and their annotated locations for NP_001229311.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (6) lacks a single internal aa compared to isoform 1.
    Source sequence(s)
    AL928804, BP758238, CF746204, HQ533147
    UniProtKB/TrEMBL
    R4H243
    Conserved Domains (3) summary
    TIGR00834
    Location:1181060
    ae; anion exchange protein
    pfam00955
    Location:475988
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:146434
    Band_3_cyto; Band 3 cytoplasmic domain
  6. NM_001242383.1NP_001229312.1  sodium-driven chloride bicarbonate exchanger isoform 7

    See identical proteins and their annotated locations for NP_001229312.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice junction at the 5' end of an exon and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (7) lacks two alternate internal segments compared to isoform 1.
    Source sequence(s)
    AL928804, BP758238, CF746204, HQ533147
    UniProtKB/TrEMBL
    E9NX85, R4H243
    Conserved Domains (1) summary
    cl26877
    Location:1181030
    Band_3_cyto; Band 3 cytoplasmic domain
  7. NM_001362671.1NP_001349600.1  sodium-driven chloride bicarbonate exchanger isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL772323, AL928613, AL928804, BP758238
    Conserved Domains (1) summary
    cl26877
    Location:1171060
    Band_3_cyto; Band 3 cytoplasmic domain
  8. NM_001362672.1NP_001349601.1  sodium-driven chloride bicarbonate exchanger isoform 9

    Status: VALIDATED

    Source sequence(s)
    BC039226, BP758238, JF500487, JX220977
    Conserved Domains (1) summary
    cl26877
    Location:1171059
    Band_3_cyto; Band 3 cytoplasmic domain
  9. NM_001362673.1NP_001349602.1  sodium-driven chloride bicarbonate exchanger isoform 10

    Status: VALIDATED

    Source sequence(s)
    BC039226, BP758238, JF500487, JX254917
    Conserved Domains (1) summary
    cl26877
    Location:1171030
    Band_3_cyto; Band 3 cytoplasmic domain
  10. NM_001362674.1NP_001349603.1  sodium-driven chloride bicarbonate exchanger isoform 11

    Status: VALIDATED

    Source sequence(s)
    BC039226, BP758238, JF500487
    Conserved Domains (1) summary
    cl26877
    Location:1171030
    Band_3_cyto; Band 3 cytoplasmic domain
  11. NM_001362675.1NP_001349604.1  sodium-driven chloride bicarbonate exchanger isoform 12

    Status: VALIDATED

    Source sequence(s)
    BC039226, BP758238, JF500488
    Conserved Domains (1) summary
    cl26877
    Location:1171060
    Band_3_cyto; Band 3 cytoplasmic domain
  12. NM_001362676.1NP_001349605.1  sodium-driven chloride bicarbonate exchanger isoform 13

    Status: VALIDATED

    Source sequence(s)
    BC039226, BP758238, JF500489
    Conserved Domains (1) summary
    cl26877
    Location:1171030
    Band_3_cyto; Band 3 cytoplasmic domain
  13. NM_033552.3NP_291030.2  sodium-driven chloride bicarbonate exchanger isoform 2

    See identical proteins and their annotated locations for NP_291030.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK043017, AL928804, BP758238, CF746204, DN176790
    Consensus CDS
    CCDS16064.1
    UniProtKB/TrEMBL
    Q8C943
    Related
    ENSMUSP00000099796.4, ENSMUST00000102735.10
    Conserved Domains (3) summary
    TIGR00834
    Location:1181031
    ae; anion exchange protein
    pfam00955
    Location:446959
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:146405
    Band_3_cyto; Band 3 cytoplasmic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    61876815..62157087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252258.2XP_030108118.1  sodium-driven chloride bicarbonate exchanger isoform X4

    Conserved Domains (1) summary
    pfam00955
    Location:1469
    HCO3_cotransp; HCO3- transporter family
  2. XM_036162733.1XP_036018626.1  sodium-driven chloride bicarbonate exchanger isoform X3

    Conserved Domains (1) summary
    cl26877
    Location:1171029
    Band_3_cyto; Band 3 cytoplasmic domain
  3. XM_017319349.3XP_017174838.1  sodium-driven chloride bicarbonate exchanger isoform X2

    Conserved Domains (1) summary
    cl26877
    Location:1171029
    Band_3_cyto; Band 3 cytoplasmic domain
  4. XM_011239858.4XP_011238160.1  sodium-driven chloride bicarbonate exchanger isoform X1

    Conserved Domains (1) summary
    cl26877
    Location:1171059
    Band_3_cyto; Band 3 cytoplasmic domain
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