Loxl2 lysyl oxidase-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Loxl2provided by MGI
Official Full Name: lysyl oxidase-like 2provided by MGI
Primary source: MGI:MGI:2137913
See related: Ensembl:ENSMUSG00000034205 AllianceGenome:MGI:2137913
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110004B06Rik; 4930526G11Rik; 9430067E15Rik
Summary: Predicted to enable metal ion binding activity; oligosaccharide binding activity; and protein-lysine 6-oxidase activity. Involved in negative regulation of stem cell population maintenance; positive regulation of chondrocyte differentiation; and response to hypoxia. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in brain. Orthologous to human LOXL2 (lysyl oxidase like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 41.7), ovary adult (RPKM 38.9) and 21 other tissues See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 14 D2; 14 36.06 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (69846085..69933283)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (69608692..69695834)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of LOXL2 induced by glucose metabolism-activated NF-kappaB in maintaining drug resistance through EMT and cancer stemness in gemcitabine-resistant PDAC.
Title: The role of LOXL2 induced by glucose metabolism-activated NF-κB in maintaining drug resistance through EMT and cancer stemness in gemcitabine-resistant PDAC.
Lysyl oxidase-like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3.
Title: Lysyl oxidase-like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3.
Loss of LOXL2 Promotes Uterine Hypertrophy and Tumor Progression by Enhancing H3K36ac-Dependent Gene Expression.
Title: Loss of LOXL2 Promotes Uterine Hypertrophy and Tumor Progression by Enhancing H3K36ac-Dependent Gene Expression.
Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development.
Title: Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development.
An in situ activity assay for lysyl oxidases.
Title: An in situ activity assay for lysyl oxidases.
Significance of nuclear LOXL2 inhibition in fibroblasts and myofibroblasts in the fibrotic process of acute respiratory distress syndrome.
Title: Significance of nuclear LOXL2 inhibition in fibroblasts and myofibroblasts in the fibrotic process of acute respiratory distress syndrome.
LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis.
Title: LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis.
for the first time, report the role of Withaferin A in modulating the expression of LOXL2 and Snail1 in addition to vimentin inhibition and regulation of NFkappaB signaling for the treatment of liver fibrosis.
Title: Withaferin A reverses bile duct ligation-induced liver fibrosis by modulating extracellular matrix deposition: Role of LOXL2/Snail1, vimentin, and NFκB signaling.
Lysyl oxidase-like 2 drives vascular stiffening during aging by promoting matrix remodeling and vascular smooth muscle cell stiffening.
Title: Lysyl oxidase-like 2 depletion is protective in age-associated vascular stiffening.
Our study demonstrates that systemic LOXL2 adenovirus or LOXL2 genetic overexpression in mice can protect against OA. These findings demonstrate the potential for LOXL2 gene therapy for knee-OA clinical treatment in the future.
Title: Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

BB104597 (e-PCR)
- UniSTS:186008

NoName (e-PCR)
- UniSTS:237218

D14Mit89 (e-PCR), detects polymorphism
- UniSTS:127446

RH124140 (e-PCR)
- UniSTS:161004

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oligosaccharide binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	IEA Inferred from Electronic Annotation more info
enables protein-lysine 6-oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine 6-oxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in collagen fibril organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in collagen fibril organization	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-lysine oxidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
involved_in response to copper ion	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basement membrane	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: lysyl oxidase homolog 2

Names: lysyl oxidase-like protein 2

NP_201582.2

EC 1.4.3.13

XP_006519807.1

EC 1.4.3.13

XP_006519810.1

EC 1.4.3.13

XP_036014834.1

EC 1.4.3.13

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033325.2 → NP_201582.2 lysyl oxidase homolog 2 precursor

See identical proteins and their annotated locations for NP_201582.2

Status: VALIDATED

Source sequence(s)

AA437829, AC160639, AK045019, AK159386

Consensus CDS

CCDS27241.1

UniProtKB/Swiss-Prot

P58022, Q8BRE6, Q8BS86, Q8C4K0, Q9JJ39

Related

ENSMUSP00000097987.3, ENSMUST00000100420.4

Conserved Domains (2) summary

smart00202
Location:61 → 162

SR; Scavenger receptor Cys-rich

pfam01186
Location:550 → 750

Lysyl_oxidase; Lysyl oxidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

69846085..69933283

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519744.4 → XP_006519807.1 lysyl oxidase homolog 2 isoform X1

See identical proteins and their annotated locations for XP_006519807.1

Conserved Domains (2) summary

smart00202
Location:61 → 162

SR; Scavenger receptor Cys-rich

pfam01186
Location:557 → 757

Lysyl_oxidase; Lysyl oxidase
XM_036158941.1 → XP_036014834.1 lysyl oxidase homolog 2 isoform X2

Conserved Domains (2) summary

smart00202
Location:61 → 162

SR; Scavenger receptor Cys-rich

pfam01186
Location:557 → 756

Lysyl_oxidase; Lysyl oxidase
XM_006519747.3 → XP_006519810.1 lysyl oxidase homolog 2 isoform X3

See identical proteins and their annotated locations for XP_006519810.1

UniProtKB/Swiss-Prot

P58022, Q8BRE6, Q8BS86, Q8C4K0, Q9JJ39

Related

ENSMUSP00000022660.7, ENSMUST00000022660.14

Conserved Domains (2) summary

smart00202
Location:61 → 162

SR; Scavenger receptor Cys-rich

pfam01186
Location:550 → 750

Lysyl_oxidase; Lysyl oxidase