acpP acyl carrier protein [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Gene symbol: acpP
Gene description: acyl carrier protein
Primary source: ASAP:ABE-0003703
Locus tag: b1094
See related: ECOCYC:EG50003
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK1080
Summary: Ser36 is phosphopantethylated by AcpS. [More information is available at EcoGene: EG50003]. Acyl carrier protein (ACP) plays an important role in fatty acid biosynthesis. [More information is available at EcoCyc: EG50003].
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Genomic context

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Sequence:: NC_000913.3 (1151615..1151851)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD.
Title: Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD.
analysis of acyl carrier protein conserved modular elements and their roles in lipid synthesis
Title: The conserved modular elements of the acyl carrier proteins of lipid synthesis are only partially interchangeable.
The studies highlight key interactions of transient ACP-LpxD protein complexes and define the dynamic movements of ACP that facilitate substrate delivery and trigger complex dissociation.
Title: Crystal structures of acyl carrier protein in complex with two catalytic partners show a dynamic role in cellular metabolism.
crystal structures of three forms of Escherichia coli acyl carrier protein engaging LpxD, which represent stalled substrate and liberated products along the reaction coordinate
Title: Chasing acyl carrier protein through a catalytic cycle of lipid A production.
ACP must be able to adopt a folded conformation for biological activity, and its function does not require complete unfolding of the protein
Title: Intein-mediated cyclization of bacterial acyl carrier protein stabilizes its folded conformation but does not abolish function.
Studies shed light on a key aspect of ACP biology and provide insights into the mechanism involved.
Title: Catalysis and mechanism of malonyl transferase activity in type II fatty acid biosynthesis acyl carrier proteins.
solution structures determined of three different forms of ACP, apo-ACP, ACP, and butyryl-ACP under identical experimental conditions; structural studies revealed that attachment of butyryl acyl intermediate to ACP alters the conformation of ACP
Title: Structural modification of acyl carrier protein by butyryl group.
N-terminus verified by Edman degradation on mature peptide
Title: Amounts of proteins altered by mutations in the dnaA gene of Escherichia coli.
Study characterizes the physical interaction between SpoT and acyl carrier protein (ACP) using affinity co-purifications and two-hybrid in E. coli.
Title: Acyl carrier protein/SpoT interaction, the switch linking SpoT-dependent stress response to fatty acid metabolism.
crystallographic analysis of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli
Title: Structure of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables acyl binding	IBA Inferred from Biological aspect of Ancestor more info
enables acyl binding	IDA Inferred from Direct Assay more info	PubMed
enables acyl binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables acyl carrier activity	IBA Inferred from Biological aspect of Ancestor more info
enables acyl carrier activity	IDA Inferred from Direct Assay more info	PubMed
enables acyl carrier activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphopantetheine binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid A biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid A biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: acyl carrier protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

1151615..1151851

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_415612.1 acyl carrier protein [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_415612.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A5B9AWB3

Conserved Domains (1) summary

PRK00982
Location:1 → 78

acpP; acyl carrier protein; Provisional