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murD UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944818, updated on 7-Jul-2019

Summary

Gene symbol
murD
Gene description
UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase
Primary source
EcoGene:EG10620
Locus tag
b0088
See related
ASAP:ABE-0000318; ECOCYC:EG10620
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0089
Summary
A carbamylated lysine residue is present in the active site. [More information is available at EcoGene: EG10620]. UDP-N-acetylmuramoylalanine-D-glutamate ligase catalyzes the addition of the second amino acid to the peptide moiety of the monomer unit of peptidoglycan. [More information is available at EcoCyc: EG10620].

Genomic context

Sequence:
NC_000913.3 (97087..98403)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidoglycan DD-transpeptidase FtsI Neighboring gene UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase Neighboring gene D-alanyl-D-alanine-adding enzyme Neighboring gene phospho-N-acetylmuramoyl-pentapeptide-transferase Neighboring gene putative lipid II flippase FtsW Neighboring gene N-acetylglucosaminyl transferase Neighboring gene UDP-N-acetylmuramate--L-alanine ligase Neighboring gene D-alanine--D-alanine ligase B

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
UDP-N-acetylmuramoylalanine-D-glutamate ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
peptidoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase
NP_414630.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    97087..98403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414630.1 UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414630.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P14900
    Conserved Domains (1) summary
    PRK03806
    Location:1438
    murD; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
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