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eno enolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945032, updated on 4-Apr-2024

Summary

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Gene symbol
eno
Gene description
enolase
Primary source
ASAP:ABE-0009110
Locus tag
b2779
See related
ECOCYC:EG10258
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2773
Summary
Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG10258]. Enolase catalyzes the interconversion of 2-phosphoglycerate and phosphoenolpyruvate. [More information is available at EcoCyc: EG10258].
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Genomic context

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Sequence:
NC_000913.3 (2906643..2907941, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cell envelope stress response protein YqcG Neighboring gene TPM domain-containing protein YgcG Neighboring gene CTP synthetase Neighboring gene nucleoside triphosphate pyrophosphohydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular recognition between Escherichia coli enolase and ribonuclease E. Nurmohamed S, et al. Acta Crystallogr D Biol Crystallogr, 2010 Sep. PMID 20823555, Free PMC Article
  2. Functional and structural changes due to a serine to alanine mutation in the active-site flap of enolase. Poyner RR, et al. Arch Biochem Biophys, 2002 May 15. PMID 12054465
  3. Crystal structure of the Escherichia coli RNA degradosome component enolase. Kühnel K, et al. J Mol Biol, 2001 Oct 26. PMID 11676541
  4. Cloning, nucleotide sequence, and functional expression of the Escherichia coli enolase (eno) gene in a temperature-sensitive eno mutant strain. Klein M, et al. DNA Seq, 1996. PMID 8988374
  5. The purification and characterization of Escherichia coli enolase. Spring TG, et al. J Biol Chem, 1971 Nov 25. PMID 4942326

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. crystal structure of enolase bound to its cognate site from RNase E (residues 823-850) at 1.9 A resolution is presented
    Title: Molecular recognition between Escherichia coli enolase and ribonuclease E.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: '98 Escherichia coli SWISS-2DPAGE database update.
  3. Data suggest that enolase within the degradosome plays a crucial role in the regulation of glucose transporter ptsG mRNA stability in response to a metabolic stress.
    Title: Enolase in the RNA degradosome plays a crucial role in the rapid decay of glucose transporter mRNA in the response to phosphosugar stress in Escherichia coli.
  4. Enolase is recruited into putative RNA degradosome machinery in these bacilli, where it plays common regulatory functions.
    Title: Recognition of enolase in the Escherichia coli RNA degradosome.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphopyruvate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphopyruvate hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphopyruvate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in RNA processing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of bacterial degradosome IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of phosphopyruvate hydratase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphopyruvate hydratase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of phosphopyruvate hydratase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
enolase
NP_417259.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2906643..2907941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417259.1 enolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417259.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7FS01
    Conserved Domains (1) summary
    PRK00077
    Location:1 → 432
    eno; enolase; Provisional
Nucleotide Protein
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Other Literature Sources
Molecular Biology Databases
Research Materials