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galT galactose-1-phosphate uridylyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945357, updated on 11-Apr-2024

Summary

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Gene symbol
galT
Gene description
galactose-1-phosphate uridylyltransferase
Primary source
ASAP:ABE-0002573
Locus tag
b0758
See related
ECOCYC:EG10366
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0747; galB
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Genomic context

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Sequence:
NC_000913.3 (789983..791029, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase Neighboring gene galactose-1-epimerase Neighboring gene galactokinase Neighboring gene UDP-glucose 4-epimerase Neighboring gene ABC family protein ModF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification and properties of galactose 1-phosphate uridyl transferase from Escherichia coli. KURAHASHI K, et al. J Biol Chem, 1960 Apr. PMID 14412847
  2. Roles of two conserved amino acid residues in the active site of galactose-1-phosphate uridylyltransferase: an essential serine and a nonessential cysteine. Geeganage S, et al. Biochemistry, 2000 May 9. PMID 10820011
  3. Significance of metal ions in galactose-1-phosphate uridylyltransferase: an essential structural zinc and a nonessential structural iron. Geeganage S, et al. Biochemistry, 1999 Oct 5. PMID 10529216
  4. Transient kinetics of formation and reaction of the uridylyl-enzyme form of galactose-1-P uridylyltransferase and its Q168R-variant: insight into the molecular basis of galactosemia. Geeganage S, et al. Biochemistry, 1998 Oct 13. PMID 9772178
  5. Structural analysis of the H166G site-directed mutant of galactose-1-phosphate uridylyltransferase complexed with either UDP-glucose or UDP-galactose: detailed description of the nucleotide sugar binding site. Thoden JB, et al. Biochemistry, 1997 Feb 11. PMID 9063869

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: E. coli galactose-1-phosphate uridyl transferase: N-terminal and C-terminal sequences.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactokinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in galactose catabolic process via UDP-galactose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galactose catabolic process via UDP-galactose IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within galactose catabolic process via UDP-galactose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in galactose metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
galactose-1-phosphate uridylyltransferase
NP_415279.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    789983..791029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415279.1 galactose-1-phosphate uridylyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415279.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7L5V515
    Conserved Domains (1) summary
    PRK11720
    Location:1 → 346
    PRK11720; UDP-glucose--hexose-1-phosphate uridylyltransferase
Nucleotide Protein
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