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rutA pyrimidine monooxygenase RutA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945643, updated on 2-May-2024

Summary

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Gene symbol
rutA
Gene description
pyrimidine monooxygenase RutA
Primary source
ASAP:ABE-0003416
Locus tag
b1012
See related
ECOCYC:G6523
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1003; ycdM
Summary
NtrC regulon. [More information is available at EcoGene: EG13859]. Escherichia coli K-12 contains a previously undescribed pathway for pyrimidine degradation. [More information is available at EcoCyc: G6523].
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Genomic context

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Sequence:
NC_000913.3 (1072863..1074011, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative aminoacrylate hydrolase RutD Neighboring gene 3-aminoacrylate deaminase Neighboring gene ureidoacrylate amidohydrolase Neighboring gene DNA-binding transcriptional dual regulator RutR Neighboring gene fused DNA-binding transcriptional repressor/proline dehydrogenase/1-pyrroline-5-carboxylate dehydrogenase PutA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases. Matthews A, et al. Nat Chem Biol, 2020 May. PMID 32066967
  2. Catalysis of a flavoenzyme-mediated amide hydrolysis. Mukherjee T, et al. J Am Chem Soc, 2010 Apr 28. PMID 20369853, Free PMC Article
  3. Comparative genomics reveals novel biochemical pathways. Piskur J, et al. Trends Genet, 2007 Aug. PMID 17555842
  4. A hidden metabolic pathway exposed. Osterman A. Proc Natl Acad Sci U S A, 2006 Apr 11. PMID 16595627, Free PMC Article
  5. The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems. Kim KS, et al. J Bacteriol, 2010 Aug. PMID 20400551, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RutA structure has a structural motif for dioxygen activation and N5-functionalization.
    Title: Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables alkanesulfonate monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables uracil oxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uracil oxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in alkanesulfonate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nitrogen utilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nitrogen utilization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nitrogen utilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pyrimidine nucleobase catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thymine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in uracil catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in uracil catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within uracil catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
pyrimidine monooxygenase RutA
NP_415532.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1072863..1074011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415532.3 pyrimidine monooxygenase RutA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415532.3

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    B7LFC2, B7N3G8
    UniProtKB/TrEMBL
    A0A148HS85, A0A8T9D3G5, A0AA35AHJ0, E1IPW6
    Conserved Domains (1) summary
    TIGR03612
    Location:20 → 374
    RutA; pyrimidine utilization protein A
Nucleotide Protein
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Gene LinkOut

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