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holB DNA polymerase III subunit delta' [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945661, updated on 23-Nov-2023

Summary

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Gene symbol
holB
Gene description
DNA polymerase III subunit delta'
Primary source
ASAP:ABE-0003716
Locus tag
b1099
See related
ECOCYC:EG11500
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1085
Summary
The crystal structure of delta' has been determined. [More information is available at EcoCyc: EG11500].
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Genomic context

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Sequence:
NC_000913.3 (1155762..1156766)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene aminodeoxychorismate lyase Neighboring gene endolytic murein transglycosylase Neighboring gene Tmk Neighboring gene putative metal-dependent hydrolase YcfH Neighboring gene glucose-specific PTS enzyme IIBC component

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Carboxyl-terminal domain III of the delta' subunit of the DNA polymerase III holoenzyme binds delta. Song MS, et al. J Biol Chem, 2001 Nov 2. PMID 11518714
  2. The delta and delta ' subunits of the DNA polymerase III holoenzyme are essential for initiation complex formation and processive elongation. Song MS, et al. J Biol Chem, 2001 Sep 14. PMID 11432857
  3. A novel assembly mechanism for the DNA polymerase III holoenzyme DnaX complex: association of deltadelta' with DnaX(4) forms DnaX(3)deltadelta'. Pritchard AE, et al. EMBO J, 2000 Dec 1. PMID 11101526, Free PMC Article
  4. A slow ATP-induced conformational change limits the rate of DNA binding but not the rate of beta clamp binding by the escherichia coli gamma complex clamp loader. Thompson JA, et al. J Biol Chem, 2009 Nov 13. PMID 19759003, Free PMC Article
  5. A method for the construction of in frame substitutions in operons: deletion of the essential Escherichia coli holB gene coding for a subunit of the DNA polymerase III holoenzyme. Chaperon DN. J Microbiol Methods, 2006 Apr. PMID 16083981

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: DNA polymerase III accessory proteins. I. holA and holB encoding delta and delta'.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3'-5' exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA-templated DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA-templated DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA polymerase III complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of DNA polymerase III complex IEA
Inferred from Electronic Annotation
more info
  
part_of DNA polymerase III complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of DNA polymerase III, clamp loader complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of replisome NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
DNA polymerase III subunit delta'

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1155762..1156766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415617.1 DNA polymerase III subunit delta' [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415617.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A793CBT5
    Conserved Domains (1) summary
    PRK07993
    Location:1 → 334
    PRK07993; DNA polymerase III subunit delta'; Validated
Nucleotide Protein
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Gene LinkOut

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