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narK nitrate:nitrite antiporter NarK [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945783, updated on 2-May-2024

Summary

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Gene symbol
narK
Gene description
nitrate:nitrite antiporter NarK
Primary source
ASAP:ABE-0004111
Locus tag
b1223
See related
ECOCYC:EG10642
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1217
Summary
Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG10642]. NarU and NarK are the two nitrate transporters in Escherichia coli. [More information is available at EcoCyc: EG10642].
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Genomic context

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Sequence:
NC_000913.3 (1277957..1279348)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative invasin YchO Neighboring gene DNA-binding transcriptional dual regulator NarL Neighboring gene sensor histidine kinase NarX Neighboring gene ncRNA Neighboring gene nitrate reductase A subunit alpha Neighboring gene nitrate reductase A subunit beta Neighboring gene nitrate reductase 1 molybdenum cofactor assembly chaperone Neighboring gene nitrate reductase A subunit gamma

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. How do antiporters exchange substrates across the cell membrane? An atomic-level description of the complete exchange cycle in NarK. Feng J, et al. Structure, 2021 Aug 5. PMID 33836147
  2. Isolation of an oxygen-sensitive FNR protein of Escherichia coli: interaction at activator and repressor sites of FNR-controlled genes. Melville SB, et al. Proc Natl Acad Sci U S A, 1996 Feb 6. PMID 8577745, Free PMC Article
  3. Pulmonary injury associated with appendicitis in pregnancy: who is at risk? de Veciana M, et al. Am J Obstet Gynecol, 1994 Oct. PMID 7943063
  4. Influence of nar (nitrate reductase) genes on nitrate inhibition of formate-hydrogen lyase and fumarate reductase gene expression in Escherichia coli K-12. Stewart V, et al. J Bacteriol, 1988 Oct. PMID 3049531, Free PMC Article
  5. NarK enhances nitrate uptake and nitrite excretion in Escherichia coli. DeMoss JA, et al. J Bacteriol, 1991 Jun. PMID 2045360, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables nitrate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nitrite transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables solute:inorganic anion antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in nitrate assimilation IEA
Inferred from Electronic Annotation
more info
  
involved_in nitrate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitrate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nitrate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitrite transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nitrite transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
nitrate:nitrite antiporter NarK

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1277957..1279348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415741.1 nitrate:nitrite antiporter NarK [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415741.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A895P481
    Conserved Domains (1) summary
    cl28910
    Location:8 → 463
    MFS; Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version

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