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topA DNA topoisomerase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945862, updated on 7-Jul-2019

Summary

Gene symbol
topA
Gene description
DNA topoisomerase 1
Primary source
EcoGene:EG11013
Locus tag
b1274
See related
ASAP:ABE-0004275; ECOCYC:EG11013
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1268; supX
Summary
Topoisomerase I is a type IA topoisomerase which is responsible for relaxing negative supercoils in DNA. [More information is available at EcoCyc: EG11013].

Genomic context

Sequence:
NC_000913.3 (1331048..1333645)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene S49 peptidase family protein Neighboring gene protein YciN Neighboring gene DNA-binding transcriptional dual regulator CysB Neighboring gene uncharacterized protein YmiA

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
DNA topoisomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA topoisomerase type I activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA topological change IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA topoisomerase 1
NP_415790.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1331048..1333645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415790.1 DNA topoisomerase 1 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415790.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P06612
    Conserved Domains (1) summary
    PRK07561
    Location:2849
    PRK07561; DNA topoisomerase I subunit omega; Validated
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