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tar methyl-accepting chemotaxis protein Tar [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946399, updated on 11-Apr-2024

Summary

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Gene symbol
tar
Gene description
methyl-accepting chemotaxis protein Tar
Primary source
ASAP:ABE-0006290
Locus tag
b1886
See related
ECOCYC:EG10988
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cheM; ECK1887
Summary
Tar senses maltose indirectly through periplasmic maltose binding protein. [More information is available at EcoGene: EG10988]. Tar is a chemoreceptor which senses aspartate and exists as a functional homodimer . [More information is available at EcoCyc: EG10988].
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Genomic context

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Sequence:
NC_000913.3 (1971030..1972691, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene chemotaxis protein methyltransferase Neighboring gene methyl-accepting chemotaxis protein Tap Neighboring gene chemotaxis protein CheW Neighboring gene chemotaxis protein CheA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bacterial Chemoreceptor Dynamics: Helical Stability in the Cytoplasmic Domain Varies with Functional Segment and Adaptational Modification. Bartelli NL, et al. J Mol Biol, 2016 Sep 25. PMID 27318193, Free PMC Article
  2. Residues at the cytoplasmic end of transmembrane helix 2 determine the signal output of the TarEc chemoreceptor. Adase CA, et al. Biochemistry, 2013 Apr 23. PMID 23495653
  3. Mistic and TarCF as fusion protein partners for functional expression of the cannabinoid receptor 2 in Escherichia coli. Chowdhury A, et al. Protein Expr Purif, 2012 Jun. PMID 22406258, Free PMC Article
  4. Direct evidence that the carboxyl-terminal sequence of a bacterial chemoreceptor is an unstructured linker and enzyme tether. Bartelli NL, et al. Protein Sci, 2011 Nov. PMID 21858888, Free PMC Article
  5. Engineered single- and multi-cell chemotaxis pathways in E. coli. Goldberg SD, et al. Mol Syst Biol, 2009. PMID 19536206, Free PMC Article

See all (146) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Blue light is a universal signal for Escherichia coli chemoreceptors.
    Title: Blue Light Is a Universal Signal for Escherichia coli Chemoreceptors.
  2. Thus, the proportion of polypeptide chain that is locally and presumably transiently disordered is a structural feature of cytoplasmic domain dynamics that varies with functional region and modification-induced signaling state.
    Title: Bacterial Chemoreceptor Dynamics: Helical Stability in the Cytoplasmic Domain Varies with Functional Segment and Adaptational Modification.
  3. There is a differential repositioning of the second transmembrane helices from E. coli Tar and EnvZ upon moving the flanking aromatic residues.
    Title: Differential repositioning of the second transmembrane helices from E. coli Tar and EnvZ upon moving the flanking aromatic residues.
  4. the Tar(FO) modules demonstrate that trimerized signaling tips self-associate, bind CheA and CheW, and facilitate conversion of CheA to an active conformation.
    Title: Preformed Soluble Chemoreceptor Trimers That Mimic Cellular Assembly States and Activate CheA Autophosphorylation.
  5. Residues at the cytoplasmic end of transmembrane helix 2 determine the signal output of the Tar chemoreceptor.
    Title: Residues at the cytoplasmic end of transmembrane helix 2 determine the signal output of the TarEc chemoreceptor.
  6. Such inversion is enabled by opposing pH sensing by the two major chemoreceptors, Tar and Tsr, such that the relative strength of the response is modulated by adaptive receptor methylation.
    Title: Opposite responses by different chemoreceptors set a tunable preference point in Escherichia coli pH taxis.
  7. Here we report the overexpression system for aCB2 in Escherichia coli C43(DE3) facilitated by two fusion partners: Mistic and TarCF, a C-terminal fragment of the bacterial chemosensory transducer Tar at the C-terminal of the CB2 open reading frame region.
    Title: Mistic and TarCF as fusion protein partners for functional expression of the cannabinoid receptor 2 in Escherichia coli.
  8. characterization of structural features of carboxyl-terminal 40 residues of Tar; identifed carboxyl-terminal linker between receptor body and the pentapeptide is an unstructured, disordered segment that can serve as a flexible arm and enzyme tether
    Title: Direct evidence that the carboxyl-terminal sequence of a bacterial chemoreceptor is an unstructured linker and enzyme tether.
  9. Ligand specificity is determined by differentially arranged common ligand-binding residues in bacterial amino acid chemoreceptors Tsr and Tar
    Title: Ligand specificity determined by differentially arranged common ligand-binding residues in bacterial amino acid chemoreceptors Tsr and Tar.
  10. Tar molecules with the cytoplasmic methylation and kinase control domains of Tsr still sensed phenol as an attractant.
    Title: Phenol sensing by Escherichia coli chemoreceptors: a nonclassical mechanism.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein histidine kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of chemical stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of post-translational protein modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein homooligomerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of methyl accepting chemotaxis protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of methyl accepting chemotaxis protein complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
methyl-accepting chemotaxis protein Tar

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1971030..1972691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416400.1 methyl-accepting chemotaxis protein Tar [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416400.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AA86ZXH9
    Conserved Domains (1) summary
    PRK15048
    Location:1 → 553
    PRK15048; methyl-accepting chemotaxis protein II; Provisional
Nucleotide Protein
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