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gmm GDP-mannose mannosyl hydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946559, updated on 4-Feb-2024

Summary

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Gene symbol
gmm
Gene description
GDP-mannose mannosyl hydrolase
Primary source
ASAP:ABE-0006796
Locus tag
b2051
See related
ECOCYC:EG11789
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2045; nudD; wcaH; yefC
Summary
Nudix hydrolase. [More information is available at EcoGene: EG11789]. GDP-mannose mannosyl hydrolase (GDPMH) is able to hydrolyze both GDP-mannose and GDP-glucose. [More information is available at EcoCyc: EG11789].
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Genomic context

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Sequence:
NC_000913.3 (2125743..2126222, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphomannomutase Neighboring gene mannose-1-phosphate guanylyltransferase Neighboring gene colanic acid biosynthesis fucosyltransferase WcaI Neighboring gene GDP-L-fucose synthase Neighboring gene GDP-mannose 4,6-dehydratase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular basis for substrate selectivity and specificity by an LPS biosynthetic enzyme. Zou Y, et al. Biochemistry, 2007 Apr 10. PMID 17371001
  2. Kinetic and magnetic resonance studies of the role of metal ions in the mechanism of Escherichia coli GDP-mannose mannosyl hydrolase, an unusual nudix enzyme. Legler PM, et al. Biochemistry, 2002 Apr 9. PMID 11926828
  3. GDP-mannose mannosyl hydrolase catalyzes nucleophilic substitution at carbon, unlike all other Nudix hydrolases. Legler PM, et al. Biochemistry, 2000 Jul 25. PMID 10913267
  4. A novel GDP-mannose mannosyl hydrolase shares homology with the MutT family of enzymes. Frick DN, et al. J Biol Chem, 1995 Oct 13. PMID 7592609
  5. Evidence for effect of random genetic drift on G+C content after lateral transfer of fucose pathway genes to Escherichia coli K-12. Aoyama K, et al. Mol Biol Evol, 1994 Nov. PMID 7815923

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GDP-glucosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP-mannose mannosyl hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP-mannose mannosyl hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GDP-mannose mannosyl hydrolase
NP_416555.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2125743..2126222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416555.2 GDP-mannose mannosyl hydrolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416555.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0K4TWI1, A0A1X3JE67, A0A7U9QEV0, F4VGY0, G1UGG6
    Conserved Domains (1) summary
    PRK15434
    Location:1 → 159
    PRK15434; GDP-mannose mannosyl hydrolase
Nucleotide Protein
Heading Accession and Version

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