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folX dihydroneopterin triphosphate 2'-epimerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946781, updated on 23-Nov-2023

Summary

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Gene symbol
folX
Gene description
dihydroneopterin triphosphate 2'-epimerase
Primary source
ASAP:ABE-0007603
Locus tag
b2303
See related
ECOCYC:G7195
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2297
Summary
Dihydroneopterin triphosphate 2'-epimerase has been known in Escherichia coli for some time. [More information is available at EcoCyc: G7195].
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Genomic context

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Sequence:
NC_000913.3 (2421325..2421687)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase YfcF Neighboring gene disulfide bond oxidoreductase YfcG Neighboring gene epimerase family protein YfcH Neighboring gene recombination-promoting nuclease RpnB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. (6R)-5,6,7,8-tetrahydro-L-monapterin from Escherichia coli, a novel natural unconjugated tetrahydropterin. Ikemoto K, et al. Biol Chem, 2002 Feb. PMID 11934271
  2. Crystal structure of 7,8-dihydroneopterin triphosphate epimerase. Ploom T, et al. Structure, 1999 May. PMID 10378270
  3. Purification, cloning, and functional expression of dihydroneopterin triphosphate 2'-epimerase from Escherichia coli. Ahn C, et al. J Biol Chem, 1997 Jun 13. PMID 9182560
  4. Pteridine excretion from cells as indicator of cell proliferation. Wachter H, et al. Naturwissenschaften, 1980 Dec. PMID 7015154
  5. Enzymatic epimerization of D-erythro-dihydroneopterin triphosphate to L-threo-dihydroneopterin triphosphate. Heine MC, et al. Biochim Biophys Acta, 1975 Dec 5. PMID 1103974

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In E. coli, the folX deletion selectively eliminated tetrahydromonapterin production, which far exceeded folate production.
    Title: FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa.
  2. Site-directed mutagenesis study finds glutamate-73 important for substrate binding of dihydroneopterin aldolase (DHNA), but its role in catalysis is minor. Glu-21 and Lys-98 are important for both substrate binding and catalysis.
    Title: Mechanism of dihydroneopterin aldolase: functional roles of the conserved active site glutamate and lysine residues.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Purification, cloning, and functional expression of dihydroneopterin triphosphate 2'-epimerase from Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables dihydroneopterin aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydroneopterin triphosphate 2'-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydroneopterin triphosphate 2'-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydroneopterin triphosphate 2'-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in folic acid-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pteridine-containing compound biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dihydroneopterin triphosphate 2'-epimerase
NP_416806.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2421325..2421687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416806.1 dihydroneopterin triphosphate 2'-epimerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416806.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X3K9A0
    Conserved Domains (1) summary
    PRK11245
    Location:1 → 120
    folX; dihydroneopterin triphosphate 2'-epimerase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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