U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mltB membrane-bound lytic murein transglycosylase B [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947184, updated on 4-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
mltB
Gene description
membrane-bound lytic murein transglycosylase B
Primary source
ASAP:ABE-0008885
Locus tag
b2701
See related
ECOCYC:G7410
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2696; slt
Summary
MltB cleaves the glycosidic bonds between the N-acetylmuramic acid and N-acetylglucosamine residues in murein. [More information is available at EcoGene: EG12699]. MltB is one of six (along with MltA, MltC, MltD, EmtA, and Slt70) major lytic endotransglycosylases expressed in Escherichia coli. [More information is available at EcoCyc: G7410].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (2824491..2825576, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA recombination/repair protein RecA Neighboring gene NMN aminohydrolase Neighboring gene sorbitol-specific PTS enzyme IIC2 component Neighboring gene sorbitol-specific PTS enzyme IIBC1 component Neighboring gene sorbitol-specific PTS enzyme IIA component

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Lytic transglycosylase MltB of Escherichia coli and its role in recycling of peptidoglycan strands of bacterial cell wall. Suvorov M, et al. J Am Chem Soc, 2008 Sep 10. PMID 18700763, Free PMC Article
  2. Crystallographic studies of the interactions of Escherichia coli lytic transglycosylase Slt35 with peptidoglycan. van Asselt EJ, et al. Biochemistry, 2000 Feb 29. PMID 10684641
  3. Binding of calcium in the EF-hand of Escherichia coli lytic transglycosylase Slt35 is important for stability. van Asselt EJ, et al. FEBS Lett, 1999 Sep 24. PMID 10570954
  4. Crystal structure of Escherichia coli lytic transglycosylase Slt35 reveals a lysozyme-like catalytic domain with an EF-hand. van Asselt EJ, et al. Structure, 1999 Oct 15. PMID 10545329
  5. Accelerated X-ray structure elucidation of a 36 kDa muramidase/transglycosylase using wARP. Van Asselt EJ, et al. Acta Crystallogr D Biol Crystallogr, 1998 Jan 1. PMID 9761817

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lytic endotransglycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lytic transglycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lytic transglycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sodium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidoglycan catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within peptidoglycan catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane-bounded periplasmic space TAS
Traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
membrane-bound lytic murein transglycosylase B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2824491..2825576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417181.1 membrane-bound lytic murein transglycosylase B [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417181.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AA87HBP3
    Conserved Domains (1) summary
    PRK10760
    Location:1 → 361
    PRK10760; murein hydrolase B; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.