fbaA fructose-bisphosphate aldolase class II [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Gene symbol: fbaA
Gene description: fructose-bisphosphate aldolase class II
Primary source: ASAP:ABE-0009600
Locus tag: b2925
See related: ECOCYC:EG10282
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ald; ECK2921; fba; fda
Summary: Binds TrxA (Kumar, 2004). kbaY, gatY, fbaA and ydjI are paralogs. [More information is available at EcoGene: EG10282]. The amino acid sequence of the Escherichia coli Class II fructose-1,6-bisphosphate aldolase inferred from the DNA sequence of the fda gene is the first primary structure of a Class II aldolase to be established. [More information is available at EcoCyc: EG10282].
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NC_000913.3 Genomic Context describing neighboring genes

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N-terminus verified by Edman degradation on mature peptide
Title: Escherichia coli YrbI is 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase.
Thermostable variants of the Class II fructose bisphosphate aldolase have been isolated following four rounds of directed evolution using DNA shuffling of the fda genes from Escherichia coli and Edwardsiella ictaluri
Title: A thermostable variant of fructose bisphosphate aldolase constructed by directed evolution also shows increased stability in organic solvents.
fbaA is cotranscribed with pgk, from promoter epd P0 or an internal pgk P1 promoter of the extended -10 class and its expression depends on an RNase E segmentation process.
Title: Characterization of the molecular mechanisms involved in the differential production of erythrose-4-phosphate dehydrogenase, 3-phosphoglycerate kinase and class II fructose-1,6-bisphosphate aldolase in Escherichia coli.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables aldehyde-lyase activity	IEA Inferred from Electronic Annotation more info
enables fructose-bisphosphate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose-bisphosphate aldolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fructose-bisphosphate aldolase activity	IEA Inferred from Electronic Annotation more info
enables fructose-bisphosphate aldolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_417400.1

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The following sections contain reference sequences that belong to a specific genome build. Explain