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hemC hydroxymethylbilane synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947759, updated on 23-Nov-2023

Summary

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Gene symbol
hemC
Gene description
hydroxymethylbilane synthase
Primary source
ASAP:ABE-0012427
Locus tag
b3805
See related
ECOCYC:EG10429
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3799; popE
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Genomic context

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Sequence:
NC_000913.3 (3989825..3990766, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein HemY Neighboring gene PF04375 family protein HemX Neighboring gene uroporphyrinogen-III synthase Neighboring gene adenylate cyclase Neighboring gene frataxin CyaY Neighboring gene protein YzcX

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Catalytic mechanism and DNA substrate recognition of Escherichia coli MutY protein. Lu AL, et al. J Biol Chem, 1996 Sep 27. PMID 8798653
  2. Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound to the protein through the sulphur atom of cysteine-242. Miller AD, et al. Biochem J, 1988 Sep 15. PMID 3196304, Free PMC Article
  3. Investigation into the nature of substrate binding to the dipyrromethane cofactor of Escherichia coli porphobilinogen deaminase. Warren MJ, et al. Biochemistry, 1988 Dec 13. PMID 3069132
  4. Purification, crystallization and properties of porphobilinogen deaminase from a recombinant strain of Escherichia coli K12. Jordan PM, et al. Biochem J, 1988 Sep 1. PMID 3052434, Free PMC Article
  5. Evidence that pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase). Miller AD, et al. Biochem J, 1989 Aug 15. PMID 2510713, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Purification, crystallization and properties of porphobilinogen deaminase from a recombinant strain of Escherichia coli K12.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables hydroxymethylbilane synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxymethylbilane synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydroxymethylbilane synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxymethylbilane synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heme biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protoporphyrinogen IX biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrapyrrole biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tetrapyrrole biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
hydroxymethylbilane synthase
YP_026260.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3989825..3990766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026260.1 hydroxymethylbilane synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_026260.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3PYP8, B1LLX5
    Conserved Domains (1) summary
    PRK00072
    Location:4 → 296
    hemC; porphobilinogen deaminase; Reviewed
Nucleotide Protein
Heading Accession and Version

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