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argR DNA-binding transcriptional dual regulator ArgR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947861, updated on 4-Feb-2024

Summary

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Gene symbol
argR
Gene description
DNA-binding transcriptional dual regulator ArgR
Primary source
ASAP:ABE-0010620
Locus tag
b3237
See related
ECOCYC:EG10070
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3226; Rarg; xerA
Summary
ArgR is a protein that negatively controls the expression of arginine biosynthesis in addition to the carAB operon. [More information is available at EcoCyc: EG10070].
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Genomic context

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Sequence:
NC_000913.3 (3384703..3385173)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene serine endoprotease Neighboring gene malate dehydrogenase Neighboring gene DUF1471 domain-containing stress-induced protein YhcN Neighboring gene putative barnase inhibitor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The architecture of ArgR-DNA complexes at the genome-scale in Escherichia coli. Cho S, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25735747, Free PMC Article
  2. Escherichia coli ArgR mutants defective in cer/Xer recombination, but not in DNA binding. Sénéchal H, et al. FEMS Microbiol Lett, 2010 Apr. PMID 20659168
  3. The potential for the formation of the arginine biosynthetic enzymes and its masking during evolution. Maas WK. Bioessays, 2007 May. PMID 17450599
  4. The arginine regulon of Escherichia coli: whole-system transcriptome analysis discovers new genes and provides an integrated view of arginine regulation. Caldara M, et al. Microbiology (Reading), 2006 Nov. PMID 17074904
  5. Assembly of the hexameric Escherichia coli arginine repressor investigated by nano-electrospray ionization time-of-flight mass spectrometry. Samalíková M, et al. Rapid Commun Mass Spectrom, 2005. PMID 16106344

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli.
    Title: Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli.
  2. three ArgR-binding modes defined by the position of the two ARG boxes indicate that DNA bends centered between the pair of ARG boxes facilitate the non-specific contacts between ArgR subunits and the residual sequences
    Title: The architecture of ArgR-DNA complexes at the genome-scale in Escherichia coli.
  3. These results show that the C-terminus of ArgR is more important in cer/Xer site-specific recombination than in DNA binding.
    Title: Escherichia coli ArgR mutants defective in cer/Xer recombination, but not in DNA binding.
  4. ArgR-dependent repression of arginine and histidine transport genes in Escherichia coli K-12
    Title: ArgR-dependent repression of arginine and histidine transport genes in Escherichia coli K-12.
  5. N-terminus verified by Edman degradation on complete protein
    Title: Nucleotide sequence of the argR gene of Escherichia coli K-12 and isolation of its product, the arginine repressor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables arginine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables arginine binding IEA
Inferred from Electronic Annotation
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in arginine metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within plasmid recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein complex oligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of arginine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of arginine catabolic process IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator ArgR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3384703..3385173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417704.1 DNA-binding transcriptional dual regulator ArgR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417704.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376LBX8
    Conserved Domains (1) summary
    PRK05066
    Location:1 → 156
    PRK05066; transcriptional regulator ArgR
Nucleotide Protein
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