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insA1 IS1 family protein InsA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948449, updated on 4-Apr-2024

Summary

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Gene symbol
insA1
Gene description
IS1 family protein InsA
Primary source
ASAP:ABE-0000078
Locus tag
b0022
See related
ECOCYC:G6086
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0023
Summary
IS1 is inserted in 7 locations in MG1655, designated IS1ABCDEFH; IS1G is specific to the W3110 K-12 chromosome. [More information is available at EcoGene: EG60003]. IS1 is the smallest insertion sequence in Escherichia coli. [More information is available at EcoCyc: G6086].
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Genomic context

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Sequence:
NC_000913.3 (20233..20508, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Na(+):H(+) antiporter NhaA Neighboring gene DNA-binding transcriptional activator NhaR Neighboring gene IS1 family protein InsB Neighboring gene 30S ribosomal subunit protein S20 Neighboring gene DUF2575 domain-containing protein YaaY

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. IS1R-mediated plasticity of IncL/M plasmids leads to the insertion of bla OXA-48 into the Escherichia coli Chromosome. Beyrouthy R, et al. Antimicrob Agents Chemother, 2014 Jul. PMID 24752261, Free PMC Article
  2. Genetic analyses of the interactions of the IS1-encoded proteins with the left end of IS1 and its insertion hotspot. Matsutani S. J Mol Biol, 1997 Apr 4. PMID 9126837
  3. The insE open reading frame of IS1 is not required for formation of cointegrates. Freund ET, et al. J Bacteriol, 1996 Apr. PMID 8636048, Free PMC Article
  4. Frameshifting is required for production of the transposase encoded by insertion sequence 1. Sekine Y, et al. Proc Natl Acad Sci U S A, 1989 Jun. PMID 2543983, Free PMC Article
  5. Four types of IS1 with differences in nucleotide sequence reside in the Escherichia coli K-12 chromosome. Umeda M, et al. Gene, 1991 Feb 1. PMID 1849492

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these findings indicate a plasticity of the OXA-48 genetic environment mediated by IS1R insertion sequences
    Title: IS1R-mediated plasticity of IncL/M plasmids leads to the insertion of bla OXA-48 into the Escherichia coli Chromosome.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA transposition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA transposition IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA transposition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transposition IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
IS1 family protein InsA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    20233..20508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414563.1 IS1 family protein InsA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414563.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A170TVE0, A0A377C0U4, A0A3S4K392, A0A509DNY3, A7ZGQ4, C3UUR6, D7GKB4, Q6KD64, Q849W1
    Conserved Domains (1) summary
    NF033558
    Location:8 → 91
    transpos_IS1; IS1 family transposase
Nucleotide Protein
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