lamB maltose outer membrane channel/phage lambda receptor protein [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Gene symbol: lamB
Gene description: maltose outer membrane channel/phage lambda receptor protein
Primary source: ASAP:ABE-0013218
Locus tag: b4036
See related: ECOCYC:EG10528
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK4028; malB; malL
Summary: LamB also facilitates the diffusion of maltooligosaccharides, i.e maltodextrin. [More information is available at EcoGene: EG10528]. LamB is a member of the Sugar Porin (SP) family. [More information is available at EcoCyc: EG10528].
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Genomic context

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Sequence:: NC_000913.3 (4247971..4249311)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LamB, OmpC, and the Core Lipopolysaccharide of Escherichia coli K-12 Function as Receptors of Bacteriophage Bp7.
Title: LamB, OmpC, and the Core Lipopolysaccharide of Escherichia coli K-12 Function as Receptors of Bacteriophage Bp7.
Our data indicate that the negative regulation by LamB is widely detected in antibiotic-resistant E. coli. LamB serves as a porin to influx an antibiotic and is interacted with Odp1.
Title: Decreased expression of LamB and Odp1 complex is crucial for antibiotic resistance in Escherichia coli.
Elevated expression of LamB causes cell death when the osmoregulator OmpR is disabled.
Title: Constitutive expression of the maltoporin LamB in the absence of OmpR damages the cell envelope.
Results report the crystallization of E. coli maltoporin in a new crystal form; the crystals belonged to the trigonal R3 space group and diffracted to 1.9 A resolution.
Title: Crystallization of Escherichia coli maltoporin in the trigonal space group R3.
downregulation of LamB expression in the CTC-resistant E. coli strain and the increased antibiotic resistance in its gene-deleted strain suggested a negative regulation mechanism in E. coli in response to CTC
Title: A novel negative regulation mechanism of bacterial outer membrane proteins in response to antibiotic resistance.
Data report that cells lacking OmpR and harboring constitutively active MalT undergo premature death that involves increased expression of the outer membrane porin LamB.
Title: A critical process controlled by MalT and OmpR is revealed through synthetic lethality.
N-terminus verified by Edman degradation on mature peptide
Title: Major proteins of the Escherichia coli outer cell envelope membrane. Preliminary characterization of the phage lambda receptor protein.
all aromatic residues provide some steric hindrance for ion transport through LamB
Title: Site-directed mutagenesis of the greasy slide aromatic residues within the LamB (maltoporin) channel of Escherichia coli: effect on ion and maltopentaose transport.
demonstrated that LamB moves along the bacterial surface and that these movements are restricted by an underlying dynamic spiral pattern
Title: Complex spatial distribution and dynamics of an abundant Escherichia coli outer membrane protein, LamB.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables carbohydrate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables maltodextrin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables maltodextrin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables maltose transporting porin activity	IEA Inferred from Electronic Annotation more info
enables porin activity	IBA Inferred from Biological aspect of Ancestor more info
enables porin activity	IDA Inferred from Direct Assay more info	PubMed
enables porin activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables virus receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEP Inferred from Expression Pattern more info	PubMed
involved_in carbohydrate transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within maltodextrin transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in maltodextrin transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in maltose transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in organic substance transport	IEA Inferred from Electronic Annotation more info
involved_in polysaccharide transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cell outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell outer membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of pore complex	IBA Inferred from Biological aspect of Ancestor more info
part_of pore complex	IDA Inferred from Direct Assay more info	PubMed
part_of pore complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: maltose outer membrane channel/phage lambda receptor protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

4247971..4249311

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_418460.1 maltose outer membrane channel/phage lambda receptor protein [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_418460.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A2X5NX10

Conserved Domains (1) summary

PRK09360
Location:1 → 446

lamB; maltoporin LamB