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purA adenylosuccinate synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948695, updated on 11-Oct-2018

Summary

Gene symbol
purA
Gene description
adenylosuccinate synthetase
Primary source
EcoGene:EG10790
Locus tag
b4177
See related
ASAP:ABE-0013672; ECOCYC:EG10790
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
adeK; ECK4173
Summary
Adenylosuccinate synthetase catalyzes the first committed step toward the de novo synthesis of AMP. [More information is available at EcoCyc: EG10790].

Genomic context

Sequence:
NC_000913.3 (4404687..4405985)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene regulator of FtsH protease Neighboring gene DUF2065 domain-containing protein YjeT Neighboring gene DNA-binding transcriptional repressor NsrR Neighboring gene RNase R

Bibliography

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
adenylosuccinate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylosuccinate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
'de novo' AMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
IMP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenosine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
nucleobase-containing small molecule interconversion IDA
Inferred from Direct Assay
more info
PubMed 
purine nucleotide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adenylosuccinate synthetase
NP_418598.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4404687..4405985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418598.1 adenylosuccinate synthetase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418598.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0A7D4
    Conserved Domains (1) summary
    PRK01117
    Location:2432
    PRK01117; adenylosuccinate synthetase; Provisional
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