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deoA thymidine phosphorylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948901, updated on 4-Apr-2024

Summary

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Gene symbol
deoA
Gene description
thymidine phosphorylase
Primary source
ASAP:ABE-0014374
Locus tag
b4382
See related
ECOCYC:EG10219
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4374; TP; tpp; ttg
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Genomic context

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Sequence:
NC_000913.3 (4618229..4619551)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative glycyl-radical enzyme activating enzyme YjjW Neighboring gene DUF3029 domain-containing protein YjjI Neighboring gene deoxyribose-phosphate aldolase Neighboring gene phosphopentomutase Neighboring gene purine nucleoside phosphorylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kinetics and mechanistic study of competitive inhibition of thymidine phosphorylase by 5-fluoruracil derivatives. Petaccia M, et al. Colloids Surf B Biointerfaces, 2016 Apr 1. PMID 26752208
  2. Substrate specificity of thymidine phosphorylase of E. coli: role of hydroxyl groups. Panova NG, et al. Nucleosides Nucleotides Nucleic Acids, 2008 Dec. PMID 19003566
  3. Substrate specificity of Escherichia coli thymidine phosphorylase. Panova NG, et al. Biochemistry (Mosc), 2007 Jan. PMID 17309433
  4. Thymidine phosphorylase is noncompetitively inhibited by 5'-O-trityl-inosine (KIN59) and related compounds. Liekens S, et al. Nucleosides Nucleotides Nucleic Acids, 2006. PMID 17065049
  5. Thymidine phosphorylase from Escherichia coli: tight-binding inhibitors as enzyme active-site titrants. Gbaj A, et al. J Enzyme Inhib Med Chem, 2006 Feb. PMID 16570508

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that thymidine phosphorylase enzymatic phosphorolysis of thymidine was reduced by 5-fluoruracil derivatives.
    Title: Kinetics and mechanistic study of competitive inhibition of thymidine phosphorylase by 5-fluoruracil derivatives.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 1,4-alpha-oligoglucan phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pentosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyrimidine-nucleoside phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables thymidine phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thymidine phosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thymidine phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables thymidine phosphorylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in pyrimidine nucleobase metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleoside metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in thymidine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
thymidine phosphorylase
NP_418799.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4618229..4619551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418799.1 thymidine phosphorylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418799.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AB86, A0A827YB37, A0A828PL53, A0AA87EY36
    Conserved Domains (1) summary
    PRK05820
    Location:1 → 440
    deoA; thymidine phosphorylase; Reviewed
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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