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deoC deoxyribose-phosphate aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948902, updated on 4-Feb-2024

Summary

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Gene symbol
deoC
Gene description
deoxyribose-phosphate aldolase
Primary source
ASAP:ABE-0014371
Locus tag
b4381
See related
ECOCYC:EG10221
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dra; ECK4373; thyR; tlr
Summary
DeoC is a survival protein required for MazF-mediated survival of a small subpopulation after inhibition of translation (Amitai, 2009). [More information is available at EcoGene: EG10221]. The purified enzyme may exist as both a monomer and a dimer. [More information is available at EcoCyc: EG10221].
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Genomic context

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Sequence:
NC_000913.3 (4617323..4618102)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative patatin-like phospholipase YjjU Neighboring gene putative metal-dependent hydrolase YjjV Neighboring gene putative glycyl-radical enzyme activating enzyme YjjW Neighboring gene DUF3029 domain-containing protein YjjI Neighboring gene thymidine phosphorylase Neighboring gene phosphopentomutase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Directed evolution of an industrial biocatalyst: 2-deoxy-D-ribose 5-phosphate aldolase. Jennewein S, et al. Biotechnol J, 2006 May. PMID 16892289
  2. Effect of an artificial RNA marker on gene expression in Escherichia coli. Tucker DL, et al. Appl Environ Microbiol, 2005 Jul. PMID 16000839, Free PMC Article
  3. Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution. Heine A, et al. J Mol Biol, 2004 Oct 29. PMID 15476818
  4. Observation of covalent intermediates in an enzyme mechanism at atomic resolution. Heine A, et al. Science, 2001 Oct 12. PMID 11598300
  5. Crystallization and preliminary crystallographic data for class I deoxyribose-5-phosphate aldolase from Escherichia coli: an application of reverse screening. Stura EA, et al. Proteins, 1995 May. PMID 7675789

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Direct detection of potential selenium delivery proteins by using an Escherichia coli strain unable to incorporate selenium from selenite into proteins.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables deoxyribose-phosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxyribose-phosphate aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deoxyribose-phosphate aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in carbohydrate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within carbohydrate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in carbohydrate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in deoxyribonucleotide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in deoxyribonucleotide catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within deoxyribonucleotide catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in deoxyribose phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleobase-containing small molecule interconversion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
deoxyribose-phosphate aldolase
NP_418798.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4617323..4618102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418798.1 deoxyribose-phosphate aldolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418798.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A418GYK7, A0A827Y439, A0A8T5YPJ0, D0VU03
    Conserved Domains (1) summary
    PRK05283
    Location:2 → 259
    PRK05283; deoxyribose-phosphate aldolase; Provisional
Nucleotide Protein
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