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thyA thymidylate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949035, updated on 11-Oct-2018

Summary

Gene symbol
thyA
Gene description
thymidylate synthase
Primary source
EcoGene:EG11002
Locus tag
b2827
See related
ASAP:ABE-0009268; ECOCYC:EG11002
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2823
Summary
Thymidylate synthase (TS) catalytic mechanism order: [More information is available at EcoGene: EG11002]. Thymidylate synthase plays a key role in DNA synthesis. [More information is available at EcoCyc: EG11002].

Genomic context

Sequence:
NC_000913.3 (2964361..2965155, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative YgdA Neighboring gene DUF2509 domain-containing protein YgdB Neighboring gene conserved protein PpdB Neighboring gene conserved protein PpdA Neighboring gene phosphatidylglycerol--prolipoprotein diacylglyceryl transferase Neighboring gene phosphoenolpyruvate-protein phosphotransferase PtsP

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
thymidylate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
dTMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
response to radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
thymidylate synthase
NP_417304.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2964361..2965155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417304.1 thymidylate synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417304.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0A884
    Conserved Domains (1) summary
    PRK01827
    Location:1264
    thyA; thymidylate synthase; Reviewed
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