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trxB thioredoxin reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949054, updated on 11-Apr-2024

Summary

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Gene symbol
trxB
Gene description
thioredoxin reductase
Primary source
ASAP:ABE-0003018
Locus tag
b0888
See related
ECOCYC:EG11032
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0879; trxR
Summary
Thioredoxin reductase is a member of the flavin-containing NADPH:disulfide oxidoreductases (DSOR) family. [More information is available at EcoCyc: EG11032].
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Genomic context

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Sequence:
NC_000913.3 (931085..932050, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glutathione/L-cysteine ABC exporter subunit CydC Neighboring gene glutathione/L-cysteine ABC exporter subunit CydD Neighboring gene DNA-binding transcriptional dual regulator Lrp Neighboring gene cell division DNA translocase FtsK

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein-protein interactions at an enzyme-substrate interface: characterization of transient reaction intermediates throughout a full catalytic cycle of Escherichia coli thioredoxin reductase. Negri A, et al. Proteins, 2010 Jan. PMID 19585660
  2. P22 tailspike trimer assembly is governed by interchain redox associations. Danek BL, et al. Biochim Biophys Acta, 2004 Jul 1. PMID 15210130
  3. Cell-free production of active E. coli thioredoxin reductase and glutathione reductase. Knapp KG, et al. FEBS Lett, 2004 Feb 13. PMID 14960309
  4. ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOTIDES.V. PURIFICATION AND PROPERTIES OF THIOREDOXIN REDUCTASE FROM ESCHERICHIA COLI B. MOORE EC, et al. J Biol Chem, 1964 Oct. PMID 14245401
  5. DSC studies of a family of natively disordered fragments from Escherichia coli thioredoxin: surface burial in intrinsic coils. Mendoza C, et al. Biochemistry, 2003 Mar 25. PMID 12641467

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Sequence of thioredoxin reductase from Escherichia coli. Relationship to other flavoprotein disulfide oxidoreductases.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thioredoxin-disulfide reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thioredoxin-disulfide reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of thioredoxin-disulfide reductase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
thioredoxin reductase
NP_415408.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    931085..932050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415408.1 thioredoxin reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415408.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AD87, A0A827XSR8, A0A8T5YAZ9
    Conserved Domains (1) summary
    PRK10262
    Location:1 → 320
    PRK10262; thioredoxin reductase; Provisional
Nucleotide Protein
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