CD37 CD37 molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD37provided by HGNC
Official Full Name: CD37 moleculeprovided by HGNC
Primary source: HGNC:HGNC:1666
See related: Ensembl:ENSG00000104894 MIM:151523; AllianceGenome:HGNC:1666
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GP52-40; TSPAN26
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression: Biased expression in lymph node (RPKM 111.7), spleen (RPKM 99.3) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.33

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (49335406..49340606)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (52332834..52338034)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (49838663..49843863)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD37 expression in follicular lymphoma.
Title: CD37 expression in follicular lymphoma.
CD37 high expression as a potential biomarker and association with poor outcome in acute myeloid leukemia.
Title: CD37 high expression as a potential biomarker and association with poor outcome in acute myeloid leukemia.
From a cohort of 137 primary diffuse large B-cell lymphoma (DLBCL) samples. CD37 mutations were exclusively identified in immune-privileged site-associated DLBCL (IP-DLBCL) cases but absent in non-IP-DLBCL cases. Modeling and functional analysis of CD37 missense mutations revealed loss of function by impaired CD37 protein expression at the plasma membrane of human lymphoma B cells.
Title: High frequency of inactivating tetraspanin C D37 mutations in diffuse large B-cell lymphoma at immune-privileged sites.
The anti-CD37 antibody BI 836826 in relapsed/refractory chronic lymphocytic leukemia.
Title: Phase 1 first-in-human trial of the anti-CD37 antibody BI 836826 in relapsed/refractory chronic lymphocytic leukemia.
tetraspanin CD37 controls CLEC-2 membrane organization and provides new molecular insights into the mechanisms underlying CLEC-2-dependent dendritic cell migration.
Title: C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37.
Low CD37 expression is associated with brain metastasis in lung cancer.
Title: Identification of CD37, cystatin A, and IL-23A gene expression in association with brain metastasis: analysis of a prospective trial.
CD37 is highly expressed in human lymphoma.
Title: Anti-CD37 chimeric antigen receptor T cells are active against B- and T-cell lymphomas.
CD37 is a critical determinant of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone outcome in diffuse large B-cell lymphoma.
Title: Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma.
Data indicate that cell differentiation antigen 37 (CD37) is well expressed and a potential drug target in acute myeloid leukemia (AML).
Title: AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody-Drug Conjugate as a Potential Therapeutic for B/T-Cell Malignancies and AML: A New Role for CD37 in AML.
The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model.
Title: The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD37	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	Human CD37 is relocalized from plasma membrane to a perinuclear area in the presence of HIV-1 Nef	PubMed
	nef	Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD37	PubMed
Vpu	vpu	Human CD37 is relocalized from plasma membrane to a perinuclear area in the presence of HIV-1 Vpu	PubMed
	vpu	Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD37	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

NoName (e-PCR)
- UniSTS:486994

STS-AA024912 (e-PCR)
- UniSTS:43095

RH93092 (e-PCR)
- UniSTS:84879

WI-15345 (e-PCR)
- UniSTS:80375

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leukocyte antigen CD37

Names: cell differentiation antigen 37; leukocyte surface antigen CD37; tetraspanin-26; tspan-26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033941.1 RefSeqGene

Range

4987..10187

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001040031.2 → NP_001035120.1 leukocyte antigen CD37 isoform B

See identical proteins and their annotated locations for NP_001035120.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (B) has a shorter N-terminus, compared to isoform A.

Source sequence(s)

AA767248, AC010524, AC011450

Consensus CDS

CCDS46139.1

UniProtKB/Swiss-Prot

P11049

Related

ENSP00000413151.1, ENST00000426897.6

Conserved Domains (2) summary

cd03160
Location:40 → 175

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:1 → 202

Tetraspannin; Tetraspanin family
NM_001774.3 → NP_001765.1 leukocyte antigen CD37 isoform A

See identical proteins and their annotated locations for NP_001765.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).

Source sequence(s)

AA767248, AC010524, AC011450, BP309557

Consensus CDS

CCDS12760.1

UniProtKB/Swiss-Prot

B4DVC1, P11049, Q3KPF9

UniProtKB/TrEMBL

B7ZAN3

Related

ENSP00000325708.3, ENST00000323906.9

Conserved Domains (2) summary

cd03160
Location:108 → 243

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:26 → 270

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

49335406..49340606

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005259435.4 → XP_005259492.1 leukocyte antigen CD37 isoform X1

Conserved Domains (2) summary

cd03160
Location:108 → 243

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:26 → 269

Tetraspannin; Tetraspanin family
XM_011527542.4 → XP_011525844.1 leukocyte antigen CD37 isoform X2

See identical proteins and their annotated locations for XP_011525844.1

UniProtKB/TrEMBL

M0QZP6

Conserved Domains (2) summary

cd03160
Location:40 → 175

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:1 → 201

Tetraspannin; Tetraspanin family
XM_011527543.4 → XP_011525845.1 leukocyte antigen CD37 isoform X2

See identical proteins and their annotated locations for XP_011525845.1

UniProtKB/TrEMBL

M0QZP6

Related

ENSP00000470683.1, ENST00000594743.1

Conserved Domains (2) summary

cd03160
Location:40 → 175

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:1 → 201

Tetraspannin; Tetraspanin family