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M1 matrix protein 1 [ Influenza A virus (A/Puerto Rico/8/1934(H1N1)) ]

Gene ID: 956527, updated on 18-Aug-2023

Summary

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Gene symbol
M1
Gene description
matrix protein 1
Locus tag
FLUAVs7gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (strain: A/Puerto Rico/8/1934, serotype: H1N1)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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Genomic context

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Location:
segment: 7
Sequence:
NC_002016.1 (26..784)

NC_002016.1Genomic Context describing neighboring genes Neighboring gene matrix protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002016.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conformational triggers associated with influenza matrix protein 1 polymerization. Mohd-Kipli F, et al. J Biol Chem, 2021 Jan-Jun. PMID 33516724, Free PMC Article
  2. Influenza virus Matrix Protein M1 preserves its conformation with pH, changing multimerization state at the priming stage due to electrostatics. Shtykova EV, et al. Sci Rep, 2017 Dec 1. PMID 29196731, Free PMC Article
  3. Mutations in the Influenza A Virus M1 Protein Enhance Virus Budding To Complement Lethal Mutations in the M2 Cytoplasmic Tail. Liu H, et al. J Virol, 2018 Jan 1. PMID 29046451, Free PMC Article
  4. Tyrosine 132 phosphorylation of influenza A virus M1 protein is crucial for virus replication by controlling the nuclear import of M1. Wang S, et al. J Virol, 2013 Jun. PMID 23536660, Free PMC Article
  5. Spatial structure peculiarities of influenza A virus matrix M1 protein in an acidic solution that simulates the internal lysosomal medium. Shishkov A, et al. FEBS J, 2011 Dec. PMID 21985378

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conformational triggers associated with influenza matrix protein 1 polymerization.
    Title: Conformational triggers associated with influenza matrix protein 1 polymerization.
  2. Experimental validation of influenza A virus matrix protein (M1) interaction with host cellular alpha enolase and pyruvate kinase.
    Title: Experimental validation of influenza A virus matrix protein (M1) interaction with host cellular alpha enolase and pyruvate kinase.
  3. Influenza virus matrix protein M1 interacts with SLD5 to block host cell cycle.
    Title: Influenza virus matrix protein M1 interacts with SLD5 to block host cell cycle.
  4. Data show that the protein consists of a globular N-terminal domain and a flexible C-terminal extension. The globular N-terminal domain of M1 monomers appears preserved in a pH from 4.0 to 6.8, while the C-terminal domain remains flexible and the tendency to form multimers changes dramatically. The protein multimerization process is reversible, whereby the binding between M1 molecules starts to break around pH 6.
    Title: Influenza virus Matrix Protein M1 preserves its conformation with pH, changing multimerization state at the priming stage due to electrostatics.
  5. identification of a suppressor mutations in the M1 protein which complement a lethal M2 mutation by increasing the efficiency with which virus particles bud from infected cells and restoring filament formation at the infected-cell surface.
    Title: Mutations in the Influenza A Virus M1 Protein Enhance Virus Budding To Complement Lethal Mutations in the M2 Cytoplasmic Tail.
  6. Ubiquitin and SUMO compete for the same lysine (K242) on influenza A virus M1 and the interaction of viral NS2 with human AIMP2 facilitates the switch of the M1 modification from ubiquitination to SUMOylation, thus increasing viral replication.
    Title: Interaction of NS2 with AIMP2 facilitates the switch from ubiquitination to SUMOylation of M1 in influenza A virus-infected cells.
  7. Data indicate that Itch interacted with viral M1 protein and ubiquitinated M1 protein.
    Title: Pooled RNAi screen identifies ubiquitin ligase Itch as crucial for influenza A virus release from the endosome during virus entry.
  8. Tyrosine 132 phosphorylation of M1 protein is crucial for virus replication by controlling the nuclear import of M1.
    Title: Tyrosine 132 phosphorylation of influenza A virus M1 protein is crucial for virus replication by controlling the nuclear import of M1.
  9. Neuraminidase and matrix proteins cooperate to facilitate efficient virus replication and transmissibility in pigs.
    Title: The neuraminidase and matrix genes of the 2009 pandemic influenza H1N1 virus cooperate functionally to facilitate efficient replication and transmissibility in pigs.
  10. We hypothesize that the specific 3D structural peculiarities of the M1 protein revealed in acidic pH solution allow the protein greater structural flexibility and enable it to interact effectively with the components of the host cell
    Title: Spatial structure peculiarities of influenza A virus matrix M1 protein in an acidic solution that simulates the internal lysosomal medium.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
matrix protein 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002016.1 Reference assembly

    Range
    26..784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040978.1 matrix protein 1 [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]

    See identical proteins and their annotated locations for NP_040978.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A4GCI8, A4GXH8, B4URD8, P03485, Q20N36, Q77HF4
    UniProtKB/TrEMBL
    A0A075ETM6, A0A075ETR3, A0A075ETW9, A0A075ETX2, A0A075EU24, A0A075EU61, A0A075EU83, A0A075EUG0, A0A075EUI8, A0A075EV44, A0A075EWS1, A0A075EX50, A0A075EX84, A0A075EXA5, A0A075EXI0, A0A075EXK7, A0A075EY64, A0A0A1G834, A0A0D3RZU2, A0A0E3KS53, A0A0F6Q0D8, A0A0F6Q0U7, A0A0F6Q215, A0A0F6Q218, A0A0K0P974, A0A0K0PKI4, A0A0K0PLW8, A0A0M3YZG2, A0A1B2RTV4, A0A1C9ZZ41, A0A1D8EML9, A0A1D8EMU7, A0A1U9W4V5, A0A2R4QPM6, A0A385P512, A0A5J6BW97, A3DSB2, A4ZNQ1, A4ZNR1, A5GX43, B4UPA8, B4UPD0, B4UPI1, B4UPK3, B6A6S1, B6A6T2, B6A6V4, B6A763, B6A774, B6A796, B6A7A7, B7NZ22, B8K0P8, B8K0Q9, C0RSJ2, C3PQF8, C3PQG9, C4LP12, C7RWJ6, C7RWK7, C7RWL8, C7S1X3, C7S272, C8CI19, C8CI21, C8XP18, D3J180, D5F1T4, D5F1U4, D5F1V4, D8KQS0, E3W270, F0TTA3, F0TTB4, F0TTC5, F0TTD6, F0TTE7, F0TTF8, F0TTG9, F0TTI0, F0TTJ1, F0TTK2, F0TTL3, F0TTM4, F0TTN5, F0TTP6, F0TTQ7, F0TTR8, F0TTS9, F0TTU0, F0TTV1, F0TTW2, F0TTX3, F0TTY4, F0TTZ5, F0TU06, F0TU17, F0TU28, F0TU39, F0TU50, F0TU61, F0TU72, F5CGM6, F5CGN7, F5CGP8, G0KR75, G0KU04, G0KU15, H2KIU5, H2KIV6, H2KIW5, H2KIX4, H2KIZ4, H2KJ05, H6QNR2, H8YTC6, H8YTC8, H8YTD0, H8YTD2, H8YTD4, H9XI87, H9XJP3, I6S4Z0, I6S545, I6S5A0, I6S614, I6S6D4, I6S6Q9, I6S6X8, I6S737, I6S7A8, I6S7H7, I6S8A0, I6S8J2, I6S8P6, I6S8W3, I6S8Y9, I6SHQ1, I6SI51, I6SIL3, I6SJ68, I6SK48, I6SK57, I6SK68, I6SK76, I6T1S6, I6T273, I6T2F6, I6T2X8, I6T383, I6T3D3, I6T3P4, I6T3V6, I6T425, I6T492, I6T4Y5, I6T597, I6T5G2, I6TA46, I6TAF5, I6TB16, I6TB84, I6TBN0, I6TBS9, I6TC45, I6TCH6, I6TDJ7, I6TE68, I6TE76, I6TE88, I6TEC1, I6TEK0, I6TER1, I6TEX9, I6TFC0, I6TFN5, I6TFT4, I6TG47, I6TGB7, I6TGH0, I6THM2, I7C1K3, I7CAP6, J7GV38, M9UYT3, M9UYU5, Q9DUU2, R9WJP0, R9WJV7, R9WKH6, R9WKM9, R9WKP6, R9WKY7, R9WMG5, R9WMM3, R9WNF3, R9WNL6, R9WNT9, S5FRC5, S5FS99, S5FSF2, S5FSL4, S5FTF4, S5FTM2, S5G0B9, S5G2N1, S5G2V6
    Conserved Domains (2) summary
    pfam08289
    Location:158 → 252
    Flu_M1_C; Influenza Matrix protein (M1) C-terminal domain
    pfam00598
    Location:3 → 157
    Flu_M1; Influenza Matrix protein (M1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P03485.1

Gene LinkOut

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