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SH3PXD2A SH3 and PX domains 2A [ Homo sapiens (human) ]

Gene ID: 9644, updated on 5-Mar-2024

Summary

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Official Symbol
SH3PXD2Aprovided by HGNC
Official Full Name
SH3 and PX domains 2Aprovided by HGNC
Primary source
HGNC:HGNC:23664
See related
Ensembl:ENSG00000107957 MIM:619455; AllianceGenome:HGNC:23664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FISH; TKS5; SH3MD1
Summary
Predicted to enable superoxide-generating NADPH oxidase activator activity. Involved in osteoclast fusion and superoxide metabolic process. Located in podosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 4.2), ovary (RPKM 3.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
10q24.33
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (103594027..103855576, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (104481342..104742826, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (105353784..105615334, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2781 Neighboring gene NEURL1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105253807-105254356 Neighboring gene Sharpr-MPRA regulatory region 14515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3966 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:105287340-105287840 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:105287841-105288341 Neighboring gene neuralized E3 ubiquitin protein ligase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105323539-105324519 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105329056-105329556 Neighboring gene uncharacterized LOC124902496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2785 Neighboring gene Sharpr-MPRA regulatory region 3797 Neighboring gene Sharpr-MPRA regulatory region 15000 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105367121-105367978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105380856-105381356 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105395283-105395862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105396445-105397024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105399548-105400343 Neighboring gene Sharpr-MPRA regulatory region 2777 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105417537-105418038 Neighboring gene uncharacterized LOC124902495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105441739-105442519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105451952-105452918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105455468-105456214 Neighboring gene NFE2L2 motif-containing MPRA enhancer 292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105467435-105468414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105468415-105469393 Neighboring gene NANOG hESC enhancer GRCh37_chr10:105482339-105482840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105491951-105492499 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105492500-105493047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105505582-105506103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105506520-105507020 Neighboring gene SH3PXD2A antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105507021-105507521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105515685-105516342 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105516343-105516998 Neighboring gene Sharpr-MPRA regulatory region 10495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3974 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2789 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105531100-105532070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105539219-105539718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105544793-105545294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105549545-105550545 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:105560029-105560530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2790 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105563531-105564374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105567495-105567996 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105594413-105594969 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105594970-105595525 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105667461-105668062 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 10:105668179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105677593-105678238 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:105686883-105687548 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105688215-105688880 Neighboring gene STN1 subunit of CST complex Neighboring gene uncharacterized LOC102724351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2792

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The clinicopathologic significance of Tks5 expression of peritoneal mesothelial cells in gastric cancer patients. Sugimoto A, et al. PLoS One, 2021. PMID 34255789, Free PMC Article
  2. Functional Role of the L396R Mutation of Tks5 Identified by an Exome-Wide Association Study in Atrial Fibrillation. Yang X, et al. Circ J, 2020 Nov 25. PMID 33087629
  3. Non-Syndromic Cleft Lip with or without Cleft Palate: Genome-Wide Association Study in Europeans Identifies a Suggestive Risk Locus at 16p12.1 and Supports SH3PXD2A as a Clefting Susceptibility Gene. van Rooij IA, et al. Genes (Basel), 2019 Dec 7. PMID 31817908, Free PMC Article
  4. TKS5-positive invadopodia-like structures in human tumor surgical specimens. Chen YC, et al. Exp Mol Pathol, 2019 Feb. PMID 30439350, Free PMC Article
  5. Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells. Shen Y, et al. Nat Immunol, 2017 Sep. PMID 28737753, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and tumorigenesis.
    Title: A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and tumorigenesis.
  2. Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis-a case report.
    Title: Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis-a case report.
  3. STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop affects psoriasis pathogenesis via regulating human keratinocyte proliferation.
    Title: STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop affects psoriasis pathogenesis via regulating human keratinocyte proliferation.
  4. Tks5 Regulates Synaptic Podosome Formation and Stabilization of the Postsynaptic Machinery at the Neuromuscular Junction.
    Title: Tks5 Regulates Synaptic Podosome Formation and Stabilization of the Postsynaptic Machinery at the Neuromuscular Junction.
  5. Functional Role of the L396R Mutation of Tks5 Identified by an Exome-Wide Association Study in Atrial Fibrillation.
    Title: Functional Role of the L396R Mutation of Tks5 Identified by an Exome-Wide Association Study in Atrial Fibrillation.
  6. The clinicopathologic significance of Tks5 expression of peritoneal mesothelial cells in gastric cancer patients.
    Title: The clinicopathologic significance of Tks5 expression of peritoneal mesothelial cells in gastric cancer patients.
  7. Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5alpha Promotes Cancer Invasion and Tumor Growth.
    Title: Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth.
  8. Intersection of TKS5 and FGD1/CDC42 signaling cascades directs the formation of invadopodia.
    Title: Intersection of TKS5 and FGD1/CDC42 signaling cascades directs the formation of invadopodia.
  9. The present GWAS was the first to implicate SH3PXD2A in non-syndromic cleft formation in humans. In summary, although performed in a relatively small sample, the present GWAS generated novel insights into nsCL/P etiology.
    Title: Non-Syndromic Cleft Lip with or without Cleft Palate: Genome-Wide Association Study in Europeans Identifies a Suggestive Risk Locus at 16p12.1 and Supports SH3PXD2A as a Clefting Susceptibility Gene.
  10. in the invadopodia-competent Src-3T3 model system, mutations in any one of the first three SH3 domains had a dominant negative effect that largely eliminated the presence of invadopodia, inhibited gelatin degradation activity, and redistributed both Src, cortactin, and Tks5 to what are likely endosomal compartments
    Title: Tks5 SH3 domains exhibit differential effects on invadopodia development.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylinositol-3,4-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4-phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-5-phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables protease binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables superoxide-generating NADPH oxidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoclast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in superoxide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in superoxide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in podosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SH3 and PX domain-containing protein 2A
Names
SH3 multiple domains 1
adapter protein TKS5
adaptor protein TKS5
five SH3 domain-containing protein
tyrosine kinase substrate with five SH3 domains

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365079.1 → NP_001352008.1  SH3 and PX domain-containing protein 2A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK304828, AL121929
    UniProtKB/TrEMBL
    B7Z9C6
    Conserved Domains (6) summary
    cd12019
    Location:725 → 777
    SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12020
    Location:957 → 1013
    SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12074
    Location:51 → 103
    SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12077
    Location:150 → 203
    SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12079
    Location:332 → 385
    SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    TIGR04211
    Location:741 → 826
    SH3_and_anchor; SH3 domain protein

  2. NM_001394015.1 → NP_001380944.1  SH3 and PX domain-containing protein 2A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL121929, AL133355
    Consensus CDS
    CCDS91343.1
    UniProtKB/Swiss-Prot
    D3DR98, O43302, Q5TCZ1, Q5TCZ2, Q5TDQ8
    UniProtKB/TrEMBL
    B3KPL1
    Related
    ENSP00000358789.4, ENST00000369774.9
    Conserved Domains (6) summary
    cd06888
    Location:6 → 124
    PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
    cd12019
    Location:844 → 896
    SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12020
    Location:1076 → 1132
    SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12074
    Location:170 → 222
    SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12077
    Location:269 → 322
    SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12079
    Location:451 → 504
    SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains

  3. NM_001394016.1 → NP_001380945.1  SH3 and PX domain-containing protein 2A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL121929
    UniProtKB/TrEMBL
    B7Z2H8
    Conserved Domains (6) summary
    cd12019
    Location:721 → 773
    SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12020
    Location:953 → 1009
    SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12074
    Location:47 → 99
    SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12077
    Location:146 → 199
    SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    TIGR04211
    Location:737 → 822
    SH3_and_anchor; SH3 domain protein
    cl17036
    Location:328 → 381
    SH3; Src Homology 3 domain superfamily

  4. NM_001394017.1 → NP_001380946.1  SH3 and PX domain-containing protein 2A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL121929
    UniProtKB/TrEMBL
    B7Z286
    Conserved Domains (6) summary
    cd12019
    Location:711 → 763
    SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12020
    Location:943 → 999
    SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12074
    Location:37 → 89
    SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12077
    Location:136 → 189
    SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12079
    Location:318 → 371
    SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    TIGR04211
    Location:727 → 812
    SH3_and_anchor; SH3 domain protein

  5. NM_001394018.1 → NP_001380947.1  SH3 and PX domain-containing protein 2A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL121929
    UniProtKB/TrEMBL
    B7Z286
    Conserved Domains (6) summary
    cd12019
    Location:706 → 758
    SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12020
    Location:938 → 994
    SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12074
    Location:32 → 84
    SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12077
    Location:131 → 184
    SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12079
    Location:313 → 366
    SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    TIGR04211
    Location:722 → 807
    SH3_and_anchor; SH3 domain protein

  6. NM_001394019.1 → NP_001380948.1  SH3 and PX domain-containing protein 2A isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL121929
    UniProtKB/TrEMBL
    B7Z2H8, B7Z9L8
    Conserved Domains (5) summary
    cd12019
    Location:693 → 745
    SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12020
    Location:925 → 981
    SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12074
    Location:47 → 99
    SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12077
    Location:118 → 171
    SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cl17036
    Location:300 → 353
    SH3; Src Homology 3 domain superfamily

  7. NM_001394020.1 → NP_001380949.1  SH3 and PX domain-containing protein 2A isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL121929
    UniProtKB/TrEMBL
    B7Z286
    Conserved Domains (6) summary
    cd12019
    Location:679 → 731
    SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12020
    Location:911 → 967
    SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12074
    Location:5 → 57
    SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12077
    Location:104 → 157
    SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12079
    Location:286 → 339
    SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    TIGR04211
    Location:695 → 780
    SH3_and_anchor; SH3 domain protein

  8. NM_001394021.1 → NP_001380950.1  SH3 and PX domain-containing protein 2A isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL121929
    UniProtKB/TrEMBL
    B7Z2H8
    Conserved Domains (6) summary
    cd12019
    Location:678 → 730
    SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12020
    Location:910 → 966
    SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12074
    Location:32 → 84
    SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12077
    Location:103 → 156
    SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12079
    Location:285 → 338
    SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    TIGR04211
    Location:694 → 779
    SH3_and_anchor; SH3 domain protein

  9. NM_001394022.1 → NP_001380951.1  SH3 and PX domain-containing protein 2A isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL121929
    UniProtKB/TrEMBL
    B7Z286
    Conserved Domains (5) summary
    cd12019
    Location:651 → 703
    SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12020
    Location:883 → 939
    SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12074
    Location:5 → 57
    SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12077
    Location:76 → 129
    SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cl17036
    Location:258 → 311
    SH3; Src Homology 3 domain superfamily

  10. NM_001394023.1 → NP_001380952.1  SH3 and PX domain-containing protein 2A isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL121929
    UniProtKB/TrEMBL
    B7Z286
    Conserved Domains (5) summary
    cd12019
    Location:651 → 703
    SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12020
    Location:883 → 939
    SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12074
    Location:5 → 57
    SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12077
    Location:76 → 129
    SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cl17036
    Location:258 → 311
    SH3; Src Homology 3 domain superfamily

  11. NM_014631.3 → NP_055446.2  SH3 and PX domain-containing protein 2A isoform 1

    See identical proteins and their annotated locations for NP_055446.2

    Status: VALIDATED

    Source sequence(s)
    AB007878, AK056469, AL121929, AL133355, BX647371, CN307901
    Consensus CDS
    CCDS31278.1
    UniProtKB/TrEMBL
    B3KPL1
    Related
    ENSP00000348215.2, ENST00000355946.7
    Conserved Domains (6) summary
    cd06888
    Location:6 → 124
    PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
    cd12019
    Location:816 → 868
    SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12020
    Location:1048 → 1104
    SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12074
    Location:170 → 222
    SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12077
    Location:241 → 294
    SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12079
    Location:423 → 476
    SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    103594027..103855576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    104481342..104742826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5TCZ1.1 GenPept UniProtKB/Swiss-Prot:Q5TCZ1

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