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N4BP1 NEDD4 binding protein 1 [ Homo sapiens (human) ]

Gene ID: 9683, updated on 5-Mar-2024

Summary

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Official Symbol
N4BP1provided by HGNC
Official Full Name
NEDD4 binding protein 1provided by HGNC
Primary source
HGNC:HGNC:29850
See related
Ensembl:ENSG00000102921 MIM:619138; AllianceGenome:HGNC:29850
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables mRNA binding activity; ribonuclease activity; and ubiquitin binding activity. Involved in cellular response to UV and negative regulation of viral genome replication. Predicted to be located in cytosol and nucleolus. Predicted to be active in PML body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung (RPKM 13.3), esophagus (RPKM 11.1) and 25 other tissues See more
Orthologs
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Genomic context

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See N4BP1 in Genome Data Viewer
Location:
16q12.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (48538726..48610180, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (54336403..54407853, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (48572637..48644091, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene molybdenum cofactor synthesis 1 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:48562077-48562253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:48572485-48572984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:48575532-48576032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:48576033-48576533 Neighboring gene Sharpr-MPRA regulatory region 9701 Neighboring gene ribosomal protein S2 pseudogene 44 Neighboring gene probable ribosome biogenesis protein RLP24 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7457 Neighboring gene uncharacterized LOC124903687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10801 Neighboring gene Sharpr-MPRA regulatory region 15629 Neighboring gene uncharacterized LOC105371240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:48663187-48663688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:48663689-48664188 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome through Mediating Macrophage Polarization via the miR-138-5p/EZH2 Axis. Zhao D, et al. Mediators Inflamm, 2021. PMID 35002536, Free PMC Article
  2. CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1. Nepravishta R, et al. Biomolecules, 2019 Jul 17. PMID 31319543, Free PMC Article
  3. Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma. Spel L, et al. Cancer Res, 2018 Dec 1. PMID 30213788
  4. N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation. Yamasoba D, et al. Nat Microbiol, 2019 Sep. PMID 31133753
  5. p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN. Hong SW, et al. Cell Death Differ, 2014 Jan. PMID 24141722, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N4BP1 regulates keratinocytes development and plays protective role in burn- and adhesive-related skin injury via MMP9.
    Title: N4BP1 regulates keratinocytes development and plays protective role in burn- and adhesive-related skin injury via MMP9.
  2. CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome through Mediating Macrophage Polarization via the miR-138-5p/EZH2 Axis.
    Title: CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome through Mediating Macrophage Polarization via the miR-138-5p/EZH2 Axis.
  3. Integration of innate immune signalling by caspase-8 cleavage of N4BP1.
    Title: Integration of innate immune signalling by caspase-8 cleavage of N4BP1.
  4. NEDD4-binding protein 1 (N4BP1) is a interferon-inducible inhibitor of HIV-1 in primary T cells and macrophages. N4BP1 harbours a prototypical PilT N terminus-like RNase domain and inhibits HIV-1 replication by interacting with and degrading viral mRNA species. Following activation of CD4(+) T cells, MALT lymphoma associated translocation protein cleaves N4BP1 and facilitates the reactivation of latent HIV-1 proviruses.
    Title: N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation.
  5. The p34 interacts with the WW1 domain of NEDD4-1, an interaction that enhances NEDD4-1 stability.
    Title: p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
EBI GWAS Catalog
Genome-wide association study of autistic-like traits in a general population study of young adults.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31821, KIAA0615, MGC176730

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA nuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in PML body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NEDD4-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153029.4 → NP_694574.3  NEDD4-binding protein 1

    See identical proteins and their annotated locations for NP_694574.3

    Status: VALIDATED

    Source sequence(s)
    AB014515, AK026937, AK056383, AK124782, AL831882, BC051897
    Consensus CDS
    CCDS45479.1
    UniProtKB/Swiss-Prot
    A7MD49, O75113, Q2YDX1
    Related
    ENSP00000262384.3, ENST00000262384.4
    Conserved Domains (1) summary
    pfam11977
    Location:616 → 769
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    48538726..48610180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523482.2 → XP_011521784.1  NEDD4-binding protein 1 isoform X1

    Conserved Domains (1) summary
    pfam11977
    Location:616 → 746
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

RNA

  1. XR_007064930.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    54336403..54407853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314484.1 → XP_054170459.1  NEDD4-binding protein 1 isoform X1

RNA

  1. XR_008484752.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014664.1: Suppressed sequence

    Description
    NM_014664.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75113.4 GenPept UniProtKB/Swiss-Prot:O75113

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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