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Prg4 proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) [ Mus musculus (house mouse) ]

Gene ID: 96875, updated on 25-Jan-2022

Summary

Official Symbol
Prg4provided by MGI
Official Full Name
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)provided by MGI
Primary source
MGI:MGI:1891344
See related
Ensembl:ENSMUSG00000006014 AllianceGenome:MGI:1891344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MSF; SZP; CACP; JCAP; DOL54; lubricin
Summary
Predicted to enable polysaccharide binding activity and scavenger receptor activity. Acts upstream of or within hematopoietic stem cell proliferation; negative regulation of interleukin-6 production; and regulation of cell population proliferation. Located in extracellular space. Is expressed in brain; larynx; musculoskeletal system; and spinal component of peripheral nervous system. Human ortholog(s) of this gene implicated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome and pericarditis. Orthologous to human PRG4 (proteoglycan 4). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in liver adult (RPKM 3.0), heart adult (RPKM 1.6) and 19 other tissues See more
Orthologs
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Genomic context

See Prg4 in Genome Data Viewer
Location:
1; 1 G1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (150325163..150341916, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (150449412..150466221, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (152296542..152313295, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310030A07 gene Neighboring gene phosducin Neighboring gene odr4 GPCR localization factor homolog Neighboring gene translocated promoter region, nuclear basket protein Neighboring gene predicted gene, 41967 Neighboring gene spindle and kinetochore associated complex subunit 2-like, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC161183

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables polysaccharide binding IEA
Inferred from Electronic Annotation
more info
 
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteoglycan 4
Names
megakaryocyte-stimulating factor
proteoglycan 3
superficial zone proteoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110146.1NP_001103616.1  proteoglycan 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001103616.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks internal coding exons and segments, as compared to variant 1. The resulting isoform (2) is much shorter but has identical N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AK149469, BE457731
    Consensus CDS
    CCDS48391.1
    UniProtKB/Swiss-Prot
    Q9JM99
    UniProtKB/TrEMBL
    A0A0R4J207
    Related
    ENSMUSP00000125551.2, ENSMUST00000162367.8
    Conserved Domains (2) summary
    smart00201
    Location:2668
    SO; Somatomedin B -like domains
    cd00094
    Location:161422
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
  2. NM_021400.3NP_067375.3  proteoglycan 4 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC161432
    Consensus CDS
    CCDS48392.1
    UniProtKB/TrEMBL
    E0CZ58
    Related
    ENSMUSP00000125677.2, ENSMUST00000161611.8
    Conserved Domains (4) summary
    PTZ00449
    Location:634938
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00201
    Location:2668
    SO; Somatomedin B -like domains
    PHA03247
    Location:446761
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:9591220
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    150325163..150341916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154551.1XP_036010444.1  proteoglycan 4 isoform X11

    Conserved Domains (4) summary
    PTZ00449
    Location:505809
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00201
    Location:2565
    SO; Somatomedin B -like domains
    PHA03247
    Location:317632
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:8301091
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
  2. XM_036154540.1XP_036010433.1  proteoglycan 4 isoform X4

    Conserved Domains (4) summary
    PTZ00449
    Location:593897
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00201
    Location:2567
    SO; Somatomedin B -like domains
    PHA03247
    Location:405720
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:9181179
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
  3. XM_036154548.1XP_036010441.1  proteoglycan 4 isoform X8

    Related
    ENSMUSP00000107532.3, ENSMUST00000111901.9
    Conserved Domains (5) summary
    PTZ00449
    Location:546850
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00201
    Location:2668
    SO; Somatomedin B -like domains
    PHA03247
    Location:358673
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:8711132
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam01033
    Location:69106
    Somatomedin_B; Somatomedin B domain
  4. XM_036154543.1XP_036010436.1  proteoglycan 4 isoform X5

    Conserved Domains (4) summary
    smart00201
    Location:2668
    SO; Somatomedin B -like domains
    PHA03247
    Location:402722
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:9121173
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    NF033201
    Location:667784
    Vip_LPXTG_Lm; cell invasion LPXTG protein Vip
  5. XM_036154555.1XP_036010448.1  proteoglycan 4 isoform X13

    Conserved Domains (2) summary
    smart00201
    Location:2668
    SO; Somatomedin B -like domains
    cd00094
    Location:672933
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
  6. XM_036154534.1XP_036010427.1  proteoglycan 4 isoform X2

    Conserved Domains (3) summary
    smart00201
    Location:2668
    SO; Somatomedin B -like domains
    PHA03247
    Location:428795
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:9351196
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
  7. XM_036154553.1XP_036010446.1  proteoglycan 4 isoform X12

    Related
    ENSMUSP00000107533.3, ENSMUST00000111902.9
    Conserved Domains (4) summary
    smart00201
    Location:2668
    SO; Somatomedin B -like domains
    PHA03247
    Location:452819
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:8231084
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam02389
    Location:517633
    Cornifin; Cornifin (SPRR) family
  8. XM_036154547.1XP_036010440.1  proteoglycan 4 isoform X7

    Conserved Domains (4) summary
    smart00201
    Location:2668
    SO; Somatomedin B -like domains
    PHA03247
    Location:452875
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:8791140
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam02389
    Location:573689
    Cornifin; Cornifin (SPRR) family
  9. XM_036154549.1XP_036010442.1  proteoglycan 4 isoform X9

    Conserved Domains (4) summary
    smart00201
    Location:2668
    SO; Somatomedin B -like domains
    PHA03247
    Location:403859
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:8631124
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam02389
    Location:557673
    Cornifin; Cornifin (SPRR) family
  10. XM_036154550.1XP_036010443.1  proteoglycan 4 isoform X10

    Conserved Domains (4) summary
    smart00201
    Location:2668
    SO; Somatomedin B -like domains
    PHA03247
    Location:452724
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:8551116
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam02389
    Location:501617
    Cornifin; Cornifin (SPRR) family
  11. XM_036154546.1XP_036010439.1  proteoglycan 4 isoform X6

    Conserved Domains (3) summary
    smart00201
    Location:2668
    SO; Somatomedin B -like domains
    PHA03247
    Location:452748
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:8791140
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
  12. XM_036154538.1XP_036010431.1  proteoglycan 4 isoform X3

    Conserved Domains (3) summary
    smart00201
    Location:2668
    SO; Somatomedin B -like domains
    PHA03247
    Location:403779
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:9191180
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
  13. XM_036154525.1XP_036010418.1  proteoglycan 4 isoform X1

    Related
    ENSMUSP00000128943.2, ENSMUST00000164600.8
    Conserved Domains (4) summary
    PTZ00449
    Location:634938
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00201
    Location:2668
    SO; Somatomedin B -like domains
    PHA03247
    Location:446761
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:9591220
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
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