SEC14L5 SEC14 like lipid binding 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SEC14L5provided by HGNC
Official Full Name: SEC14 like lipid binding 5provided by HGNC
Primary source: HGNC:HGNC:29032
See related: Ensembl:ENSG00000103184 MIM:619412; AllianceGenome:HGNC:29032
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PRELID4B
Expression: Biased expression in brain (RPKM 6.8), heart (RPKM 1.4) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (4958330..5019157)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (4987819..5048658)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (5008331..5069158)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This analysis revealed highly connected functional interaction networks with two candidate genes, IL15 and SEC14L5 highly enriched in networks. Overall, from these results, we concluded that these genes can be recommended as some of the potential targets for Post-Traumatic Stress Disorder.
Title: Prediction of Possible Biomarkers and Novel Pathways Conferring Risk to Post-Traumatic Stress Disorder.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68422 (e-PCR)
- UniSTS:4867

SHGC-60724 (e-PCR)
- UniSTS:1757

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SEC14-like protein 5

Names: SEC14-like 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014692.2 → NP_055507.1 SEC14-like protein 5

See identical proteins and their annotated locations for NP_055507.1

Status: VALIDATED

Source sequence(s)

AB007880, AC007011, AC026458

Consensus CDS

CCDS45403.1

UniProtKB/Swiss-Prot

O43304

Related

ENSP00000251170.6, ENST00000251170.12

Conserved Domains (3) summary

smart00516
Location:306 → 479

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

smart01100
Location:243 → 288

CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

pfam04707
Location:17 → 173

PRELI; PRELI-like family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

4958330..5019157

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024450497.2 → XP_024306265.1 SEC14-like protein 5 isoform X1

UniProtKB/Swiss-Prot

O43304

Conserved Domains (3) summary

smart00516
Location:306 → 479

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

smart01100
Location:243 → 288

CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

pfam04707
Location:17 → 173

PRELI; PRELI-like family
XM_024450498.2 → XP_024306266.1 SEC14-like protein 5 isoform X1

UniProtKB/Swiss-Prot

O43304

Conserved Domains (3) summary

smart00516
Location:306 → 479

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

smart01100
Location:243 → 288

CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

pfam04707
Location:17 → 173

PRELI; PRELI-like family

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

4987819..5048658

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054314487.1 → XP_054170462.1 SEC14-like protein 5 isoform X1

UniProtKB/Swiss-Prot

O43304
XM_054314486.1 → XP_054170461.1 SEC14-like protein 5 isoform X1

UniProtKB/Swiss-Prot

O43304