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MLEC malectin [ Homo sapiens (human) ]

Gene ID: 9761, updated on 11-Apr-2024

Summary

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Official Symbol
MLECprovided by HGNC
Official Full Name
malectinprovided by HGNC
Primary source
HGNC:HGNC:28973
See related
Ensembl:ENSG00000110917 MIM:613802; AllianceGenome:HGNC:28973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA0152
Summary
This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradation of misfolded proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in colon (RPKM 16.3), thyroid (RPKM 15.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
12q24.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120687149..120701859)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120676305..120691013)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121124952..121139662)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene CABP1 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr12:121076316-121076817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4960 Neighboring gene calcium binding protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121096155-121096656 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121096657-121097156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121104512-121105033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121105034-121105554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7146 Neighboring gene uncharacterized LOC105370029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7149 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121124755-121125256 Neighboring gene uncharacterized LOC124903035 Neighboring gene uncharacterized LOC124903036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121148178-121149020 Neighboring gene unc-119 lipid binding chaperone B Neighboring gene microRNA 4700

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Malectin gene polymorphisms promote cerebral palsy via M2-like macrophage polarization. Shi W, et al. Clin Genet, 2018 Apr. PMID 28972276
  2. Role of malectin in Glc(2)Man(9)GlcNAc(2)-dependent quality control of α1-antitrypsin. Chen Y, et al. Mol Biol Cell, 2011 Oct. PMID 21813736, Free PMC Article
  3. Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion. Takeda K, et al. Biochem Biophys Res Commun, 2014 Nov 21. PMID 25451265
  4. Malectin forms a complex with ribophorin I for enhanced association with misfolded glycoproteins. Qin SY, et al. J Biol Chem, 2012 Nov 2. PMID 22988243, Free PMC Article
  5. The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo. Pelletier MF, et al. Glycobiology, 2000 Aug. PMID 10929008

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results of in vitro studies suggest that C alleles of rs10431386 and rs7964786 on MLEC promotes cerebral palsy (CP) by inhibiting M1 to M2 macrophage polarization. Generally, this work suggested the contribution of MLEC gene polymorphisms to the pathogenesis of CP
    Title: Malectin gene polymorphisms promote cerebral palsy via M2-like macrophage polarization.
  2. These results clearly demonstrate that the association of malectin with ribophorin I is required to capture misfolded alpha1-antitrypsin and direct them to the degradation pathway.
    Title: Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion.
  3. Data indicate that malectin functions by forming a complex with ribophorin I.
    Title: Malectin forms a complex with ribophorin I for enhanced association with misfolded glycoproteins.
  4. These observations suggest a possible role of malectin in regulating newly synthesized glycoproteins via G2M9 recognition.
    Title: Role of malectin in Glc(2)Man(9)GlcNAc(2)-dependent quality control of α1-antitrypsin.
  5. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia.
  6. Malectin is a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation
    Title: Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0152

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in specific granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
malectin
Names
oligosaccharyltransferase complex subunit (non-catalytic)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303627.2 → NP_001290556.1  malectin isoform 2

    See identical proteins and their annotated locations for NP_001290556.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and coding region which results in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA831396, AC069234, BI458950
    Conserved Domains (1) summary
    pfam11721
    Location:9 → 125
    Malectin; Di-glucose binding within endoplasmic reticulum

  2. NM_001303628.2 → NP_001290557.1  malectin isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exon in the central coding region which results in a frameshift compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compare to isoform 1.
    Source sequence(s)
    AA831396, AC069234, BE326824, BG718506
    Consensus CDS
    CCDS76609.1
    UniProtKB/TrEMBL
    F5GX14
    Related
    ENSP00000440746.1, ENST00000412616.2
    Conserved Domains (1) summary
    pfam11721
    Location:48 → 135
    Malectin; Di-glucose binding within endoplasmic reticulum

  3. NM_014730.4 → NP_055545.1  malectin isoform1 precursor

    See identical proteins and their annotated locations for NP_055545.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA831396, AC069234, BC016297, BG718506
    Consensus CDS
    CCDS9206.1
    UniProtKB/Swiss-Prot
    Q14165
    Related
    ENSP00000228506.3, ENST00000228506.8
    Conserved Domains (1) summary
    pfam11721
    Location:48 → 208
    Malectin; Di-glucose binding within endoplasmic reticulum

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    120687149..120701859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539032.2 → XP_011537334.1  malectin isoform X1

    See identical proteins and their annotated locations for XP_011537334.1

    Conserved Domains (1) summary
    pfam11721
    Location:9 → 125
    Malectin; Di-glucose binding within endoplasmic reticulum

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    120676305..120691013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373907.1 → XP_054229882.1  malectin isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14165.1 GenPept UniProtKB/Swiss-Prot:Q14165

Gene LinkOut

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