U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gtf2f1 general transcription factor IIF, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 98053, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Gtf2f1provided by MGI
Official Full Name
general transcription factor IIF, polypeptide 1provided by MGI
Primary source
MGI:MGI:1923848
See related
Ensembl:ENSMUSG00000002658 AllianceGenome:MGI:1923848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RAP74; 2810405L04Rik
Summary
Predicted to enable several functions, including RNA polymerase II general transcription initiation factor activity; TFIIF-class transcription factor complex binding activity; and promoter-specific chromatin binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cell junction and nucleoplasm. Predicted to be part of transcription factor TFIID complex and transcription factor TFIIF complex. Is expressed in genitourinary system. Orthologous to human GTF2F1 (general transcription factor IIF subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 78.6), liver E14 (RPKM 38.3) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gtf2f1 in Genome Data Viewer
Location:
17 D; 17 29.62 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57310402..57318398, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57003401..57011394, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene caseinolytic mitochondrial matrix peptidase proteolytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E491 Neighboring gene alkB homolog 7 Neighboring gene persephin Neighboring gene STARR-positive B cell enhancer ABC_E492 Neighboring gene adenylate kinase 5 pseudogene Neighboring gene KH-type splicing regulatory protein Neighboring gene STARR-positive B cell enhancer ABC_E142

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. TFIIF facilitates dissociation of RNA polymerase II from noncoding RNAs that lack a repression domain. Wagner SD, et al. Mol Cell Biol, 2010 Jan. PMID 19841064, Free PMC Article
  2. Structure-function analysis of Msx2-mediated transcriptional suppression. Newberry EP, et al. Biochemistry, 1997 Aug 26. PMID 9265625
  3. Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Kamileri I, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323595, Free PMC Article
  4. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
  5. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
enables TFIIF-class transcription factor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIF complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
general transcription factor IIF subunit 1
Names
TFIIF-alpha
general transcription factor IIF polypeptide 1 (74kD subunit)
transcription initiation factor IIF subunit alpha

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419459.1 → NP_001406388.1  general transcription factor IIF subunit 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  2. NM_001419461.1 → NP_001406390.1  general transcription factor IIF subunit 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  3. NM_001419463.1 → NP_001406392.1  general transcription factor IIF subunit 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  4. NM_001419464.1 → NP_001406393.1  general transcription factor IIF subunit 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  5. NM_001419465.1 → NP_001406394.1  general transcription factor IIF subunit 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  6. NM_001419466.1 → NP_001406395.1  general transcription factor IIF subunit 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  7. NM_001419467.1 → NP_001406396.1  general transcription factor IIF subunit 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  8. NM_001419468.1 → NP_001406397.1  general transcription factor IIF subunit 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  9. NM_001419469.1 → NP_001406398.1  general transcription factor IIF subunit 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  10. NM_001419470.1 → NP_001406399.1  general transcription factor IIF subunit 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  11. NM_001419471.1 → NP_001406400.1  general transcription factor IIF subunit 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  12. NM_001419472.1 → NP_001406401.1  general transcription factor IIF subunit 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  13. NM_001419473.1 → NP_001406402.1  general transcription factor IIF subunit 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  14. NM_001419474.1 → NP_001406403.1  general transcription factor IIF subunit 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  15. NM_001419475.1 → NP_001406404.1  general transcription factor IIF subunit 1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  16. NM_001419476.1 → NP_001406405.1  general transcription factor IIF subunit 1 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  17. NM_001419477.1 → NP_001406406.1  general transcription factor IIF subunit 1 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

  18. NM_133801.3 → NP_598562.1  general transcription factor IIF subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_598562.1

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247
    Consensus CDS
    CCDS37667.1
    UniProtKB/Swiss-Prot
    Q3THK3, Q8R5B7
    Related
    ENSMUSP00000002733.7, ENSMUST00000002733.7
    Conserved Domains (1) summary
    pfam05793
    Location:2 → 508
    TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)

RNA

  1. NR_185085.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073683, CT571247

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57310402..57318398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3THK3.2 GenPept UniProtKB/Swiss-Prot:Q3THK3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous