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Dcaf8 DDB1 and CUL4 associated factor 8 [ Mus musculus (house mouse) ]

Gene ID: 98193, updated on 5-Mar-2024

Summary

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Official Symbol
Dcaf8provided by MGI
Official Full Name
DDB1 and CUL4 associated factor 8provided by MGI
Primary source
MGI:MGI:91860
See related
Ensembl:ENSMUSG00000026554 AllianceGenome:MGI:91860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H326; Wdr42a; D1Ucla4; D1Dau35e
Summary
Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; liver; lung; metanephros; and spleen. Human ortholog(s) of this gene implicated in giant axonal neuropathy 2. Orthologous to human DCAF8 (DDB1 and CUL4 associated factor 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 29.6), kidney adult (RPKM 26.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H3; 1 79.54 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171975574..172023959)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172148015..172196393)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 19 Neighboring gene STARR-positive B cell enhancer ABC_E5851 Neighboring gene STARR-seq mESC enhancer starr_03051 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene proliferation and apoptosis adaptor protein 15A Neighboring gene STARR-positive B cell enhancer ABC_E9499 Neighboring gene predicted gene 17224 Neighboring gene calsequestrin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis. Zhang X, et al. Front Med, 2021 Apr. PMID 33855678
  2. ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation. Brandao R, et al. FEBS Open Bio, 2021 Jun. PMID 33730447, Free PMC Article
  3. CRL4(DCAF8) Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver. Li G, et al. Cell Rep, 2017 Feb 7. PMID 28178526
  4. Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation. Underhill DA, et al. Mamm Genome, 2000 Aug. PMID 10920231
  5. Localization of the mouse glucocorticoid receptor-interacting protein 1 gene (Grip1) to proximal chromosome 1 by linkage analysis. Welch CL, et al. Mamm Genome, 1997 Aug. PMID 9250876

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis.
    Title: DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38511

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DDB1- and CUL4-associated factor 8
Names
WD repeat domain 42A
WD repeat-containing protein 42A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357204.2 → NP_001344133.1  DDB1- and CUL4-associated factor 8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC074310
    Consensus CDS
    CCDS15509.1
    UniProtKB/Swiss-Prot
    Q8CII7, Q8CIK6, Q8N7N5
    Related
    ENSMUSP00000141732.2, ENSMUST00000192704.6
    Conserved Domains (3) summary
    TIGR00927
    Location:17 → 177
    2A1904; K+-dependent Na+/Ca+ exchanger
    sd00039
    Location:192 → 228
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:183 → 500
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001421210.1 → NP_001408139.1  DDB1- and CUL4-associated factor 8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC074310
    UniProtKB/Swiss-Prot
    Q8CII7, Q8CIK6, Q8N7N5

  3. NM_001421211.1 → NP_001408140.1  DDB1- and CUL4-associated factor 8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC074310
    UniProtKB/Swiss-Prot
    Q8CII7, Q8CIK6, Q8N7N5

  4. NM_001421212.1 → NP_001408141.1  DDB1- and CUL4-associated factor 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC074310

  5. NM_001421213.1 → NP_001408142.1  DDB1- and CUL4-associated factor 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC074310

  6. NM_001421214.1 → NP_001408143.1  DDB1- and CUL4-associated factor 8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC074310

  7. NM_001421215.1 → NP_001408144.1  DDB1- and CUL4-associated factor 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC074310

  8. NM_153555.3 → NP_705783.1  DDB1- and CUL4-associated factor 8 isoform 1

    See identical proteins and their annotated locations for NP_705783.1

    Status: VALIDATED

    Source sequence(s)
    AC074310
    Consensus CDS
    CCDS15509.1
    UniProtKB/Swiss-Prot
    Q8CII7, Q8CIK6, Q8N7N5
    Related
    ENSMUSP00000141731.2, ENSMUST00000191689.6
    Conserved Domains (3) summary
    TIGR00927
    Location:17 → 177
    2A1904; K+-dependent Na+/Ca+ exchanger
    sd00039
    Location:192 → 228
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:183 → 500
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_151641.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC074310

  2. NR_185274.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC074310

  3. NR_185275.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC074310

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171975574..172023959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154566.1 → XP_036010459.1  DDB1- and CUL4-associated factor 8 isoform X2

    Related
    ENSMUSP00000141836.2, ENSMUST00000193638.6

RNA

  1. XR_004935312.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N7N5.1 GenPept UniProtKB/Swiss-Prot:Q8N7N5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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