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codY transcriptional repressor CodY [ Listeria monocytogenes EGD-e ]

Gene ID: 985108, updated on 4-Apr-2024

Summary

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Gene symbol
codY
Gene description
transcriptional repressor CodY
Locus tag
lmo1280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Listeria monocytogenes EGD-e (strain: EGD-e)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria
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Genomic context

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Sequence:
NC_003210.1 (1304457..1305236)

NC_003210.1Genomic Context describing neighboring genes Neighboring gene ATP-dependent protease peptidase subunit Neighboring gene ATP-dependent protease ATP-binding subunit HslU Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003210.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide identification of Listeria monocytogenes CodY-binding sites. Biswas R, et al. Mol Microbiol, 2020 Apr. PMID 31944451, Free PMC Article
  2. CodY-Mediated c-di-GMP-Dependent Inhibition of Mammalian Cell Invasion in Listeria monocytogenes. Elbakush AM, et al. J Bacteriol, 2018 Mar 1. PMID 29229701, Free PMC Article
  3. Characterization of relA and codY mutants of Listeria monocytogenes: identification of the CodY regulon and its role in virulence. Bennett HJ, et al. Mol Microbiol, 2007 Mar. PMID 17302820
  4. The Listeria transcriptional landscape from saprophytism to virulence. Toledo-Arana A, et al. Nature, 2009 Jun 18. PMID 19448609
  5. Intracellular gene expression profile of Listeria monocytogenes. Chatterjee SS, et al. Infect Immun, 2006 Feb. PMID 16428782, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide identification of Listeria monocytogenes CodY-binding sites.
    Title: Genome-wide identification of Listeria monocytogenes CodY-binding sites.
  2. The results of this study suggest that elevated c-di-GMP levels decrease the activity of the coordinator of metabolism and virulence, CodY, possibly via lower GTP levels, and that decreased CodY activity suppresses L. monocytogenes virulence by the decreased expression of the PrfA virulence regulon.
    Title: CodY-Mediated c-di-GMP-Dependent Inhibition of Mammalian Cell Invasion in Listeria monocytogenes.
  3. study provides new data on importance of the RelA & CodY systems in the adaptation of L. monocytogenes to nutritionally exacting environments encountered during infection; first direct evidence that the activity of CodY influences the outcome of infection
    Title: Characterization of relA and codY mutants of Listeria monocytogenes: identification of the CodY regulon and its role in virulence.
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General gene information

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Homology

General protein information

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Names
transcriptional repressor CodY
NP_464805.1
  • CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003210.1 Reference assembly

    Range
    1304457..1305236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_464805.1 transcriptional repressor CodY [Listeria monocytogenes EGD-e]

    See identical proteins and their annotated locations for NP_464805.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A823DFW1
    Conserved Domains (1) summary
    PRK04158
    Location:1 → 255
    PRK04158; GTP-sensing pleiotropic transcriptional regulator CodY
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8Y7J7.1

Gene LinkOut

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