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sigB RNA polymerase sigma factor SigB [ Listeria monocytogenes EGD-e ]

Gene ID: 986527, updated on 6-Oct-2023

Summary

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Gene symbol
sigB
Gene description
RNA polymerase sigma factor SigB
Locus tag
lmo0895
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Listeria monocytogenes EGD-e (strain: EGD-e)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria
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Genomic context

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Sequence:
NC_003210.1 (930671..931450)

NC_003210.1Genomic Context describing neighboring genes Neighboring gene serine phosphatase Neighboring gene anti-anti-sigma factor (antagonist of RsbW) Neighboring gene serine-protein kinase RsbW Neighboring gene indirect negative regulation of sigma B dependant gene expression (serine phosphatase) Neighboring gene transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003210.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mild Stress Conditions during Laboratory Culture Promote the Proliferation of Mutations That Negatively Affect Sigma B Activity in Listeria monocytogenes. Guerreiro DN, et al. J Bacteriol, 2020 Apr 9. PMID 32094160, Free PMC Article
  2. Role and regulation of the stress activated sigma factor sigma B (σ(B)) in the saprophytic and host-associated life stages of Listeria monocytogenes. Dorey A, et al. Adv Appl Microbiol, 2019. PMID 30798801
  3. Loss of SigB in Listeria monocytogenes Strains EGD-e and 10403S Confers Hyperresistance to Hydrogen Peroxide in Stationary Phase under Aerobic Conditions. Boura M, et al. Appl Environ Microbiol, 2016 Aug 1. PMID 27208116, Free PMC Article
  4. Role of general stress-response alternative sigma factors σ(S) (RpoS) and σ(B) (SigB) in bacterial heat resistance as a function of treatment medium pH. Ait-Ouazzou A, et al. Int J Food Microbiol, 2012 Feb 15. PMID 22177853
  5. SigB-dependent tolerance to protein synthesis-inhibiting antibiotics in Listeria monocytogenes EGDe. Zhou Q, et al. Curr Microbiol, 2012 Mar. PMID 22143398

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mild Stress Conditions during Laboratory Culture Promote the Proliferation of Mutations That Negatively Affect Sigma B Activity in Listeria monocytogenes.
    Title: Mild Stress Conditions during Laboratory Culture Promote the Proliferation of Mutations That Negatively Affect Sigma B Activity in Listeria monocytogenes.
  2. Sigma factor controlled stress sensing and the early signal transduction events. [review]
    Title: Role and regulation of the stress activated sigma factor sigma B (σ(B)) in the saprophytic and host-associated life stages of Listeria monocytogenes.
  3. Taken together, these results demonstrate that Listeria monocytogenes is inhibited by blue light in a manner that depends on reactive oxygen species, and they demonstrate clear light-dependent phenotypes associated with sigma(B) and the blue-light sensor Lmo0799.
    Title: Blue-Light Inhibition of Listeria monocytogenes Growth Is Mediated by Reactive Oxygen Species and Is Influenced by σB and the Blue-Light Sensor Lmo0799.
  4. Loss of sigB results in hyperresistance to H2O2 to the wild type) in aerobically grown stationary-phase.
    Title: Loss of SigB in Listeria monocytogenes Strains EGD-e and 10403S Confers Hyperresistance to Hydrogen Peroxide in Stationary Phase under Aerobic Conditions.
  5. alternative route to sigmaB activation exists in the absence of RsbV, a finding that is not explained by the current model for sigmaB regulation
    Title: Effects of growth phase and temperature on σB activity within a Listeria monocytogenes population: evidence for RsbV-independent activation of σB at refrigeration temperatures.
  6. determined role of general stress-response alternative sigma factors sigma(S) (RpoS) and sigma(B) (SigB) in heat resistance and the occurrence of sublethal injuries in cell envelopes of stationary-phase Escherichia coli BJ4 and Listeria monocytogenes EGD-e cells
    Title: Role of general stress-response alternative sigma factors σ(S) (RpoS) and σ(B) (SigB) in bacterial heat resistance as a function of treatment medium pH.
  7. The minimum inhibitory concentrations of tetracycline HCl and gentamicin sulphate against EGDeDeltasigB were two- and fourfold less than those for EGDe, respectively.
    Title: SigB-dependent tolerance to protein synthesis-inhibiting antibiotics in Listeria monocytogenes EGDe.
  8. The SigB response is linked to bacterial viability in an acidic environment. Mutations in rsbW correspond to impairment of SigB-dependent acid resistance in L. monocytogenes.
    Title: Intrahost passage alters SigB-dependent acid resistance and host cell-associated kinetics of Listeria monocytogenes.
  9. visible, in particular blue light is an important environmental signal with an impact on gene expression and physiology of the non-phototrophic bacterium L. monocytogenes
    Title: Blue and red light modulates SigB-dependent gene transcription, swimming motility and invasiveness in Listeria monocytogenes.
  10. Although both sigmaB and PrfA contribute to bile tolerance, sigmaB seems to play a more important role in the survival under bile salt environment.
    Title: SigB plays a major role in Listeria monocytogenes tolerance to bile stress.
Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Homology

regulatory

  • Loc: 931437-931442 regulatory_class = ribosome_binding_site

General protein information

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Names
RNA polymerase sigma factor SigB
NP_464421.1
  • sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma B is not essential for sporulation; rather it is required for maximal expression of ctc and csbA which are transcribed in the early stationary phase under conditions inimical to sporulation; induced by heat shock, salt stress, oxidative stress, glucose limitation, oxygen limitation and entry into stationary phase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003210.1 Reference assembly

    Range
    930671..931450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_464421.1 RNA polymerase sigma factor SigB [Listeria monocytogenes EGD-e]

    See identical proteins and their annotated locations for NP_464421.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8GNQ6
    Conserved Domains (1) summary
    PRK08583
    Location:1 → 257
    PRK08583; RNA polymerase sigma factor SigB; Validated
Nucleotide Protein
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