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hly listeriolysin O precursor [ Listeria monocytogenes EGD-e ]

Gene ID: 987033, updated on 6-Oct-2023

Summary

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Gene symbol
hly
Gene description
listeriolysin O precursor
Locus tag
lmo0202
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Listeria monocytogenes EGD-e (strain: EGD-e)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria
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Genomic context

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Sequence:
NC_003210.1 (205819..207408)

NC_003210.1Genomic Context describing neighboring genes Neighboring gene listeriolysin positive regulatory protein Neighboring gene miscRNA Neighboring gene phosphatidylinositol-specific phospholipase c Neighboring gene miscRNA Neighboring gene Zinc metalloproteinase precursor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003210.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel inhibitor discovery and the conformational analysis of inhibitors of listeriolysin O via protein-ligand modeling. Wang J, et al. Sci Rep, 2015 Mar 9. PMID 25749652, Free PMC Article
  2. K+ efflux is required for histone H3 dephosphorylation by Listeria monocytogenes listeriolysin O and other pore-forming toxins. Hamon MA, et al. Infect Immun, 2011 Jul. PMID 21482680, Free PMC Article
  3. Exploring the role of the CTL epitope region of listeriolysin O in the pathogenesis of Listeria monocytogenes. Lety MA, et al. Microbiology (Reading), 2006 May. PMID 16622046
  4. Characterization of the roles of activated charcoal and Chelex in the induction of PrfA regulon expression in complex medium. Gaballa A, et al. PLoS One, 2021. PMID 33914817, Free PMC Article
  5. Degradation of nuclear Ubc9 induced by listeriolysin O is dependent on K(+) efflux. Li J, et al. Biochem Biophys Res Commun, 2017 Nov 18. PMID 28911869

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of the roles of activated charcoal and Chelex in the induction of PrfA regulon expression in complex medium.
    Title: Characterization of the roles of activated charcoal and Chelex in the induction of PrfA regulon expression in complex medium.
  2. LLO promotes L. monocytogenes internalization into hepatocytes, but not into cytotrophoblasts and endothelial cells.
    Title: Relative Roles of Listeriolysin O, InlA, and InlB in Listeria monocytogenes Uptake by Host Cells.
  3. Listeriolysin O -induced down-regulation of Ubc9 is independent of Ubc9-SUMO interaction, however, it may involve phosphorylation signaling.
    Title: Degradation of nuclear Ubc9 induced by listeriolysin O is dependent on K(+) efflux.
  4. Spontaneous loss of virulence in natural populations of Listeria monocytogenes due to mutations in hlyA and PrfA has been demonstrated.
    Title: Spontaneous Loss of Virulence in Natural Populations of Listeria monocytogenes.
  5. During infection, PML undergoes oxidation-mediated multimerization, associates with the nuclear matrix, and becomes de-SUMOylated due to the pore-forming activity of the Listeria toxin listeriolysin O (LLO).
    Title: Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection.
  6. The current MD simulation work provides insights into the mechanism by which the compounds inhibit LLO at the atomic level and will be useful for the development of new, selective LLO inhibitors.
    Title: Novel inhibitor discovery and the conformational analysis of inhibitors of listeriolysin O via protein-ligand modeling.
  7. Listeria L. monocytogenes induced decrease in hTERT levels is triggered by listeriolysin O (LLO).
    Title: Role for telomerase in Listeria monocytogenes infection.
  8. findings show that listeriolysin O and other cholesterol-dependent cytolysins induce K+ efflux through pore formation at the cell membrane
    Title: K+ efflux is required for histone H3 dephosphorylation by Listeria monocytogenes listeriolysin O and other pore-forming toxins.
  9. Data suggest that CFTR transiently increases phagosomal chloride concentration after infection, potentiating LLO pore formation and vacuole lysis.
    Title: Listeria monocytogenes exploits cystic fibrosis transmembrane conductance regulator (CFTR) to escape the phagosome.
  10. These data showed that listeriolysin O-mediated cytoplasmic entry of Listeria monocytogenes could induce the activation of intracellular calcium signaling, which is essential for maturation and secretion of IL-1 alpha in macrophages.
    Title: Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes.
Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Homology

General protein information

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Names
listeriolysin O precursor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003210.1 Reference assembly

    Range
    205819..207408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_463733.1 listeriolysin O precursor [Listeria monocytogenes EGD-e]

    See identical proteins and their annotated locations for NP_463733.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2Z5T063, A0A5M3IYR4, A3F1G8, E0ACQ8
    Conserved Domains (2) summary
    pfam01289
    Location:60 → 414
    Thiol_cytolysin; Thiol-activated cytolysin
    pfam17440
    Location:418 → 519
    Thiol_cytolys_C; Thiol-activated cytolysin beta sandwich domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13128.1

Gene LinkOut

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