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actA actin-assembly inducing protein precursor [ Listeria monocytogenes EGD-e ]

Gene ID: 987035, updated on 6-Oct-2023

Summary

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Gene symbol
actA
Gene description
actin-assembly inducing protein precursor
Locus tag
lmo0204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Listeria monocytogenes EGD-e (strain: EGD-e)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria
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Genomic context

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Sequence:
NC_003210.1 (209470..211389)

NC_003210.1Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene Zinc metalloproteinase precursor Neighboring gene phospholipase C Neighboring gene lmo0206

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003210.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ActA of Listeria monocytogenes and Its Manifold Activities as an Important Listerial Virulence Factor. Pillich H, et al. Curr Top Microbiol Immunol, 2017. PMID 27726006
  2. Association of ActA to peptidoglycan revealed by cell wall proteomics of intracellular Listeria monocytogenes. García-del Portillo F, et al. J Biol Chem, 2011 Oct 7. PMID 21846725, Free PMC Article
  3. ActA is required for crossing of the fetoplacental barrier by Listeria monocytogenes. Le Monnier A, et al. Infect Immun, 2007 Feb. PMID 17118980, Free PMC Article
  4. The Metalloprotease Mpl Supports Listeria monocytogenes Dissemination through Resolution of Membrane Protrusions into Vacuoles. Alvarez DE, et al. Infect Immun, 2016 Jun. PMID 27068088, Free PMC Article
  5. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Gertler FB, et al. Cell, 1996 Oct 18. PMID 8861907

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ActA plays a major role in listerial virulence, and its absence renders bacteria intracellularly immotile and essentially non-infectious.[review]
    Title: ActA of Listeria monocytogenes and Its Manifold Activities as an Important Listerial Virulence Factor.
  2. It has been proposed that, in addition to its role in PlcB processing and vacuole escape, the metalloprotease Mpl is required for ActA processing and protrusion resolution.
    Title: The Metalloprotease Mpl Supports Listeria monocytogenes Dissemination through Resolution of Membrane Protrusions into Vacuoles.
  3. ActA associates to peptidoglycan, as revealed by cell wall proteomics of intracellular Listeria monocytogenes
    Title: Association of ActA to peptidoglycan revealed by cell wall proteomics of intracellular Listeria monocytogenes.
  4. ActA-mediated cell-to-cell spreading plays a major role in the vertical transmission of L. monocytogenes to the fetus in the murine model.
    Title: ActA is required for crossing of the fetoplacental barrier by Listeria monocytogenes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Names
actin-assembly inducing protein precursor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003210.1 Reference assembly

    Range
    209470..211389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_463735.1 actin-assembly inducing protein precursor [Listeria monocytogenes EGD-e]

    See identical proteins and their annotated locations for NP_463735.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2PPQ2, Q6E8V0, Q6EA56, Q8GNR9
    Conserved Domains (1) summary
    pfam05058
    Location:7 → 639
    ActA; ActA Protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33379.1

Gene LinkOut

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