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Osbpl6 oxysterol binding protein-like 6 [ Mus musculus (house mouse) ]

Gene ID: 99031, updated on 11-Apr-2024

Summary

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Official Symbol
Osbpl6provided by MGI
Official Full Name
oxysterol binding protein-like 6provided by MGI
Primary source
MGI:MGI:2139014
See related
Ensembl:ENSMUSG00000042359 AllianceGenome:MGI:2139014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ORP-6; mKIAA4128; 1110062M20Rik
Summary
Predicted to enable cholesterol binding activity and sterol transporter activity. Predicted to be involved in regulation of cholesterol transport. Predicted to act upstream of or within lipid transport. Predicted to be located in early endosome membrane; endoplasmic reticulum membrane; and nuclear membrane. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and hindlimb interdigital region. Orthologous to human OSBPL6 (oxysterol binding protein like 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 4.2), lung adult (RPKM 3.2) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C3; 2 44.94 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (76236848..76430991)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (76406504..76600647)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cytochrome c, testis Neighboring gene RNA binding motif protein 45 Neighboring gene STARR-seq mESC enhancer starr_04893 Neighboring gene protein kinase, interferon inducible double stranded RNA dependent activator Neighboring gene pejvakin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Oxysterol-binding protein-related protein (ORP) 6 localizes to the ER and ER-plasma membrane contact sites and is involved in the turnover of PI4P in cerebellar granule neurons. Mochizuki S, et al. Exp Cell Res, 2018 Sep 15. PMID 30028970
  2. miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux. Ouimet M, et al. Arterioscler Thromb Vasc Biol, 2016 May. PMID 26941018, Free PMC Article
  3. An oxysterol-binding protein family identified in the mouse. Anniss AM, et al. DNA Cell Biol, 2002 Aug. PMID 12215260
  4. Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Ye Q, et al. Development, 2022 Aug 15. PMID 35831953, Free PMC Article
  5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4128, MGC30542

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
oxysterol-binding protein-related protein 6
Names
OSBP-related protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290733.1 → NP_001277662.1  oxysterol-binding protein-related protein 6 isoform b

    See identical proteins and their annotated locations for NP_001277662.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AI597353, AK044411, AL928867, BY704583, CJ104457
    Consensus CDS
    CCDS71078.1
    UniProtKB/Swiss-Prot
    Q8BXR9, Q8BYW2
    UniProtKB/TrEMBL
    Q5DTM2
    Related
    ENSMUSP00000107560.2, ENSMUST00000111929.8
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:595 → 943
    Oxysterol_BP; Oxysterol-binding protein

  2. NM_001290734.1 → NP_001277663.1  oxysterol-binding protein-related protein 6 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AI597353, AK037703, AL928867, BY704583, CJ104457
    Consensus CDS
    CCDS71079.1
    UniProtKB/TrEMBL
    Q5DTM2
    Related
    ENSMUSP00000107561.3, ENSMUST00000111930.9
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:564 → 912
    Oxysterol_BP; Oxysterol-binding protein

  3. NM_001290735.1 → NP_001277664.1  oxysterol-binding protein-related protein 6 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains alternate 5' and 3' terminal exons, and it lacks several 3' exons and thus differs in both UTRs and the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    AL928905, CJ098947
    Related
    ENSMUST00000128034.2

  4. NM_145525.3 → NP_663500.2  oxysterol-binding protein-related protein 6 isoform a

    See identical proteins and their annotated locations for NP_663500.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AI597353, AK044411, AL928867, AL928905, BY704583, CJ104457
    Consensus CDS
    CCDS16158.1
    UniProtKB/TrEMBL
    F8WIZ7, Q5DTM2
    Related
    ENSMUSP00000077123.5, ENSMUST00000077972.11
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:603 → 951
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    76236848..76430991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239862.3 → XP_011238164.1  oxysterol-binding protein-related protein 6 isoform X2

    See identical proteins and their annotated locations for XP_011238164.1

    UniProtKB/Swiss-Prot
    Q8BXR9, Q8BYW2
    UniProtKB/TrEMBL
    Q5DTM2
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:595 → 943
    Oxysterol_BP; Oxysterol-binding protein

  2. XM_036162747.1 → XP_036018640.1  oxysterol-binding protein-related protein 6 isoform X6

    UniProtKB/TrEMBL
    Q5DTM2
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:559 → 907
    Oxysterol_BP; Oxysterol-binding protein

  3. XM_011239864.3 → XP_011238166.1  oxysterol-binding protein-related protein 6 isoform X3

    UniProtKB/TrEMBL
    Q5DTM2
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:578 → 926
    Oxysterol_BP; Oxysterol-binding protein

  4. XM_011239866.3 → XP_011238168.1  oxysterol-binding protein-related protein 6 isoform X5

    See identical proteins and their annotated locations for XP_011238168.1

    UniProtKB/TrEMBL
    Q5DTM2
    Related
    ENSMUSP00000139363.2, ENSMUST00000184442.2
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:570 → 918
    Oxysterol_BP; Oxysterol-binding protein

  5. XM_036162748.1 → XP_036018641.1  oxysterol-binding protein-related protein 6 isoform X9

    UniProtKB/TrEMBL
    Q5DTM2
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:534 → 882
    Oxysterol_BP; Oxysterol-binding protein

  6. XM_011239865.3 → XP_011238167.1  oxysterol-binding protein-related protein 6 isoform X4

    UniProtKB/TrEMBL
    Q5DTM2
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:572 → 920
    Oxysterol_BP; Oxysterol-binding protein

  7. XM_011239867.3 → XP_011238169.1  oxysterol-binding protein-related protein 6 isoform X7

    UniProtKB/TrEMBL
    Q5DTM2
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:547 → 895
    Oxysterol_BP; Oxysterol-binding protein

  8. XM_011239868.3 → XP_011238170.1  oxysterol-binding protein-related protein 6 isoform X8

    UniProtKB/TrEMBL
    Q5DTM2
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:539 → 887
    Oxysterol_BP; Oxysterol-binding protein

  9. XM_036162749.1 → XP_036018642.1  oxysterol-binding protein-related protein 6 isoform X10

    UniProtKB/TrEMBL
    Q5DTM2
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:503 → 851
    Oxysterol_BP; Oxysterol-binding protein

  10. XM_011239869.2 → XP_011238171.1  oxysterol-binding protein-related protein 6 isoform X11

    Conserved Domains (1) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain

  11. XM_036162751.1 → XP_036018644.1  oxysterol-binding protein-related protein 6 isoform X12

    Conserved Domains (1) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain

  12. XM_036162753.1 → XP_036018646.1  oxysterol-binding protein-related protein 6 isoform X14

    Conserved Domains (1) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain

  13. XM_036162752.1 → XP_036018645.1  oxysterol-binding protein-related protein 6 isoform X13

    Conserved Domains (1) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain

  14. XM_036162754.1 → XP_036018647.1  oxysterol-binding protein-related protein 6 isoform X15

    Conserved Domains (1) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain

  15. XM_011239859.2 → XP_011238161.1  oxysterol-binding protein-related protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011238161.1

    UniProtKB/TrEMBL
    F8WIZ7, Q5DTM2
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:603 → 951
    Oxysterol_BP; Oxysterol-binding protein

  16. XM_036162750.1 → XP_036018643.1  oxysterol-binding protein-related protein 6 isoform X10

    UniProtKB/TrEMBL
    Q5DTM2
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:503 → 851
    Oxysterol_BP; Oxysterol-binding protein

  17. XM_011239860.2 → XP_011238162.1  oxysterol-binding protein-related protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011238162.1

    UniProtKB/TrEMBL
    F8WIZ7, Q5DTM2
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:603 → 951
    Oxysterol_BP; Oxysterol-binding protein

  18. XM_036162746.1 → XP_036018639.1  oxysterol-binding protein-related protein 6 isoform X1

    UniProtKB/TrEMBL
    F8WIZ7, Q5DTM2
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:603 → 951
    Oxysterol_BP; Oxysterol-binding protein

  19. XM_030252270.1 → XP_030108130.1  oxysterol-binding protein-related protein 6 isoform X1

    UniProtKB/TrEMBL
    F8WIZ7, Q5DTM2
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:603 → 951
    Oxysterol_BP; Oxysterol-binding protein

  20. XM_030252269.1 → XP_030108129.1  oxysterol-binding protein-related protein 6 isoform X1

    UniProtKB/TrEMBL
    F8WIZ7, Q5DTM2
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:603 → 951
    Oxysterol_BP; Oxysterol-binding protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BXR9.1 GenPept UniProtKB/Swiss-Prot:Q8BXR9

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