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Osbpl6 oxysterol binding protein-like 6 [ Mus musculus (house mouse) ]

Gene ID: 99031, updated on 23-Jun-2021

Summary

Official Symbol
Osbpl6provided by MGI
Official Full Name
oxysterol binding protein-like 6provided by MGI
Primary source
MGI:MGI:2139014
See related
Ensembl:ENSMUSG00000042359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OR; ORP-6; AI596402; mKIAA4128; 1110062M20Rik
Expression
Broad expression in kidney adult (RPKM 4.2), lung adult (RPKM 3.2) and 21 other tissues See more
Orthologs
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Genomic context

See Osbpl6 in Genome Data Viewer
Location:
2; 2 C3
Exon count:
32
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (76236848..76430991)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (76406504..76600647)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (76244595..76438704)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cytochrome c, testis Neighboring gene RNA binding motif protein 45 Neighboring gene protein kinase, interferon inducible double stranded RNA dependent activator Neighboring gene pejvakin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4128, MGC30542

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sterol transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
oxysterol-binding protein-related protein 6
Names
OSBP-related protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290733.1NP_001277662.1  oxysterol-binding protein-related protein 6 isoform b

    See identical proteins and their annotated locations for NP_001277662.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AI597353, AK044411, AL928867, BY704583, CJ104457
    Consensus CDS
    CCDS71078.1
    UniProtKB/Swiss-Prot
    Q8BXR9
    Related
    ENSMUSP00000107560.2, ENSMUST00000111929.8
    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:595943
    Oxysterol_BP; Oxysterol-binding protein
  2. NM_001290734.1NP_001277663.1  oxysterol-binding protein-related protein 6 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AI597353, AK037703, AL928867, BY704583, CJ104457
    Consensus CDS
    CCDS71079.1
    UniProtKB/Swiss-Prot
    Q8BXR9
    Related
    ENSMUSP00000107561.3, ENSMUST00000111930.9
    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:564912
    Oxysterol_BP; Oxysterol-binding protein
  3. NM_001290735.1NP_001277664.1  oxysterol-binding protein-related protein 6 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains alternate 5' and 3' terminal exons, and it lacks several 3' exons and thus differs in both UTRs and the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    AL928905, CJ098947
    Related
    ENSMUST00000128034.2
  4. NM_145525.3NP_663500.2  oxysterol-binding protein-related protein 6 isoform a

    See identical proteins and their annotated locations for NP_663500.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AI597353, AK044411, AL928867, AL928905, BY704583, CJ104457
    Consensus CDS
    CCDS16158.1
    UniProtKB/Swiss-Prot
    Q8BXR9
    UniProtKB/TrEMBL
    F8WIZ7
    Related
    ENSMUSP00000077123.5, ENSMUST00000077972.11
    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:603951
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    76236848..76430991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239862.3XP_011238164.1  oxysterol-binding protein-related protein 6 isoform X2

    See identical proteins and their annotated locations for XP_011238164.1

    UniProtKB/Swiss-Prot
    Q8BXR9
    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:595943
    Oxysterol_BP; Oxysterol-binding protein
  2. XM_036162747.1XP_036018640.1  oxysterol-binding protein-related protein 6 isoform X6

    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:559907
    Oxysterol_BP; Oxysterol-binding protein
  3. XM_011239864.3XP_011238166.1  oxysterol-binding protein-related protein 6 isoform X3

    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:578926
    Oxysterol_BP; Oxysterol-binding protein
  4. XM_011239866.3XP_011238168.1  oxysterol-binding protein-related protein 6 isoform X5

    See identical proteins and their annotated locations for XP_011238168.1

    Related
    ENSMUSP00000139363.2, ENSMUST00000184442.2
    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:570918
    Oxysterol_BP; Oxysterol-binding protein
  5. XM_036162748.1XP_036018641.1  oxysterol-binding protein-related protein 6 isoform X9

    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:534882
    Oxysterol_BP; Oxysterol-binding protein
  6. XM_011239865.3XP_011238167.1  oxysterol-binding protein-related protein 6 isoform X4

    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:572920
    Oxysterol_BP; Oxysterol-binding protein
  7. XM_011239867.3XP_011238169.1  oxysterol-binding protein-related protein 6 isoform X7

    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:547895
    Oxysterol_BP; Oxysterol-binding protein
  8. XM_011239868.3XP_011238170.1  oxysterol-binding protein-related protein 6 isoform X8

    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:539887
    Oxysterol_BP; Oxysterol-binding protein
  9. XM_036162749.1XP_036018642.1  oxysterol-binding protein-related protein 6 isoform X10

    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:503851
    Oxysterol_BP; Oxysterol-binding protein
  10. XM_011239869.2XP_011238171.1  oxysterol-binding protein-related protein 6 isoform X11

    Conserved Domains (1) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
  11. XM_036162751.1XP_036018644.1  oxysterol-binding protein-related protein 6 isoform X12

    Conserved Domains (1) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
  12. XM_036162753.1XP_036018646.1  oxysterol-binding protein-related protein 6 isoform X14

    Conserved Domains (1) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
  13. XM_036162752.1XP_036018645.1  oxysterol-binding protein-related protein 6 isoform X13

    Conserved Domains (1) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
  14. XM_036162754.1XP_036018647.1  oxysterol-binding protein-related protein 6 isoform X15

    Conserved Domains (1) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
  15. XM_011239859.2XP_011238161.1  oxysterol-binding protein-related protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011238161.1

    UniProtKB/TrEMBL
    F8WIZ7
    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:603951
    Oxysterol_BP; Oxysterol-binding protein
  16. XM_036162750.1XP_036018643.1  oxysterol-binding protein-related protein 6 isoform X10

    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:503851
    Oxysterol_BP; Oxysterol-binding protein
  17. XM_011239860.2XP_011238162.1  oxysterol-binding protein-related protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011238162.1

    UniProtKB/TrEMBL
    F8WIZ7
    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:603951
    Oxysterol_BP; Oxysterol-binding protein
  18. XM_036162746.1XP_036018639.1  oxysterol-binding protein-related protein 6 isoform X1

    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:603951
    Oxysterol_BP; Oxysterol-binding protein
  19. XM_030252270.1XP_030108130.1  oxysterol-binding protein-related protein 6 isoform X1

    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:603951
    Oxysterol_BP; Oxysterol-binding protein
  20. XM_030252269.1XP_030108129.1  oxysterol-binding protein-related protein 6 isoform X1

    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:603951
    Oxysterol_BP; Oxysterol-binding protein
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