| SREBP-1 has a role in the species differential regulation of cholesterol and bile acid homeostasis via a novel mechanism of up-regulation of the hSHP gene expression | Differential regulation of human and mouse orphan nuclear receptor small heterodimer partner promoter by sterol regulatory element binding protein-1.
Kim HJ, Kim JY, Kim JY, Park SK, Seo JH, Kim JB, Lee IK, Kim KS, Choi HS. | 01/21/2010 |
| transcriptional activities to different target promoters of lipogenic and cholesterogenic genes | Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.
Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N, Yoshikawa T, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N. | 01/21/2010 |
| Role of the SREBF-1 gene in genetic predisposition of metabolic diseases such as obesity, type 2 diabetes, and dyslipidemia. | SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts.
Eberlé D, Clément K, Meyre D, Sahbatou M, Vaxillaire M, Le Gall A, Ferré P, Basdevant A, Froguel P, Foufelle F. | 01/21/2010 |
| 2 years after bilio-pancreatic diversion the degree of fat mass loss seems to interfere with regulatory binding protein 1c (SREBP-1c)gene suppression to preserve an adequate amount of fat storage | Changes in fat mass influence SREBP-1c and UCP-2 gene expression in formerly obese subjects.
Gniuli D, Rosa G, Manco M, Scarfone A, Vega N, Greco AV, Castagneto M, Vidal H, Mingrone G. | 01/21/2010 |
| Sphinglipids in endocytic compartments serve as a "molecular trap" for cholesterol, leading to a reduction in cholesterol at the endoplasmic reticulum, induction of sterol regulatory element-binding protein-1 cleavage, and up-regulation of LDL receptors. | Sphingolipid storage induces accumulation of intracellular cholesterol by stimulating SREBP-1 cleavage.
Puri V, Jefferson JR, Singh RD, Wheatley CL, Marks DL, Pagano RE. | 01/21/2010 |
| muscle cholesterol (p=0.045) and lathosterol (p=0.054) concentrations were elevated in the CC homozygotes supporting the view that endogenous cholesterol synthesis rate is SREBF-1 genotype-dependent. | Genetic variant of the SREBF-1 gene is significantly related to cholesterol synthesis in man.
Laaksonen R, Thelen KM, Päivä H, Matinheikki J, Vesalainen R, Janatuinen T, Knuuti J, Rontu R, von Bergmann K, Lütjohann D, Lehtimäki T. | 01/21/2010 |
| LXRalpha is a negative modulator of Abcd2, acting through a novel regulatory mechanism involving overlapping SREBP and LXRalpha binding sites | Liver X receptor alpha interferes with SREBP1c-mediated Abcd2 expression. Novel cross-talk in gene regulation.
Weinhofer I, Kunze M, Rampler H, Bookout AL, Forss-Petter S, Berger J. | 01/21/2010 |
| These results indicate that positional and geometrical isomers of CLAs have specific effects on gene expression of human macrophages and that t9,t11-CLA activates ABCG1 by a SREBP-1c-dependent mechanism. | Isomer specific effects of Conjugated Linoleic Acid on macrophage ABCG1 transcription by a SREBP-1c dependent mechanism.
Ecker J, Langmann T, Moehle C, Schmitz G. | 01/21/2010 |
| SREBP transcription factors play an important role in disturbed lipid metabolism in renal failure. | The potential role of sterol regulatory element binding protein transcription factors in renal injury.
Szolkiewicz M, Chmielewski M, Nogalska A, Stelmanska E, Swierczynski J, Rutkowski B. | 01/21/2010 |
| SREBP1a and APOB have roles in total and low-density lipoprotein cholesterol levels in patients with coronary artery disease | Interaction between SREBP-1a and APOB polymorphisms influences total and low-density lipoprotein cholesterol levels in patients with coronary artery disease.
Rios DL, Vargas AF, Torres MR, Zago AJ, Callegari-Jacques SM, Hutz MH. | 01/21/2010 |
| SREBP-1 not necessary for hepatic Akt-mediated hypoglycemic effect. Myr-Akt-induced hypertriglyceridemia and hepatic triglyceride accumulation mediated by Akt-induced SREBP-1 expression and mechanism involving fatty acid synthesis independent of SREBP-1. | Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.
Ono H, Shimano H, Katagiri H, Yahagi N, Sakoda H, Onishi Y, Anai M, Ogihara T, Fujishiro M, Viana AY, Fukushima Y, Abe M, Shojima N, Kikuchi M, Yamada N, Oka Y, Asano T. | 01/21/2010 |
| EC nuclei showed strong SREBP staining in human atherosclerotic lesions, suggesting a role for SREBP. Endothelial cholesterol depletion & SREBP activation play a role in inflammatory processes in which phospholipid oxidation products accumulate. | Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products.
Yeh M, Cole AL, Choi J, Liu Y, Tulchinsky D, Qiao JH, Fishbein MC, Dooley AN, Hovnanian T, Mouilleseaux K, Vora DK, Yang WP, Gargalovic P, Kirchgessner T, Shyy JY, Berliner JA. | 01/21/2010 |
| Tethered SREBP-1a and -2 homodimers, similar to the monomeric forms, activated target genes more robustly than tethered SREBP-1c homodimers. | Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers.
Datta S, Osborne TF. | 01/21/2010 |
| there is a role for sphingolipid metabolism and SREBP1 in ACTH-dependent CYP17 regulation and steroidogenesis | Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1.
Ozbay T, Rowan A, Leon A, Patel P, Sewer MB. | 01/21/2010 |
| SREBP1, activated by atorvastatin, suppressed vascular endothelial growth factor expression through the indirect interaction with the proximal tandem Sp1 sites in vascular smooth muscle cells | SREBP inhibits VEGF expression in human smooth muscle cells.
Motoyama K, Fukumoto S, Koyama H, Emoto M, Shimano H, Maemura K, Nishizawa Y. | 01/21/2010 |
| High levels of SREBP-1 protein is associted with during prostate cancer progression to androgen independence | Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence.
Ettinger SL, Sobel R, Whitmore TG, Akbari M, Bradley DR, Gleave ME, Nelson CC. | 01/21/2010 |
| nSREBPs are essential for high levels of lipid synthesis in the liver and indicate that Insig's modulate nSREBP levels by binding and retaining SCAP in the ER. | Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.
Engelking LJ, Kuriyama H, Hammer RE, Horton JD, Brown MS, Goldstein JL, Liang G., Free PMC Article | 01/21/2010 |
| effect of SREBP-1a expression on lipid metabolism at the level of the cellular protein network and the protein pattern of mitochondria | Effect of sterol regulatory element binding protein-1a on the mitochondrial protein pattern in human liver cells detected by 2D-DIGE.
Lehr S, Kotzka J, Avci H, Knebel B, Muller S, Hanisch FG, Jacob S, Haak C, Susanto F, Muller-Wieland D. | 01/21/2010 |
| Adenoviral mediated overexpression of SREBP-1c transcription factor confirms its implication in insulin-mediated stimulation of proprotein convertase subtilisin kexin 9 (PCSK9) expression | Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c.
Costet P, Cariou B, Lambert G, Lalanne F, Lardeux B, Jarnoux AL, Grefhorst A, Staels B, Krempf M. | 01/21/2010 |
| expression of SREBP-1 is affected by polyunsaturated fatty acids in human cells | Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport.
Field FJ, Born E, Murthy S, Mathur SN., Free PMC Article | 01/21/2010 |
| SREBP-1c-mediated insulin regulation of acyl-CoA synthestase 5 expression indicate that ACS-5 is involved in the anabolic fate of fatty acids. | Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1c.
Achouri Y, Hegarty BD, Allanic D, Bécard D, Hainault I, Ferré P, Foufelle F. | 01/21/2010 |
| the function of an additional SREBP-1 responsive element located in the first intron of caspase-2 gene | Identification of a functional DNA binding site for the SREBP-1c transcription factor in the first intron of the human caspase-2 gene.
Logette E, Solary E, Corcos L. | 01/21/2010 |
| Knockout of sterol regulatory element-binding protein (SREBP)-1c, had no effect on the ability of leptin to decrease either stearoyl-CoA desaturase transcript or activity. | Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c.
Biddinger SB, Miyazaki M, Boucher J, Ntambi JM, Kahn CR. | 01/21/2010 |
| Cdk1-mediated phosphorylation of S439 stabilizes mature SREBP1 during mitosis, thereby preserving a critical pool of active transcription factors to support lipid synthesis. | Cdk1/cyclin B-mediated phosphorylation stabilizes SREBP1 during mitosis.
Bengoechea-Alonso MT, Ericsson J. | 01/21/2010 |
| expression altered in obesity and niddm | Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha.
Sewter C, Berger D, Considine RV, Medina G, Rochford J, Ciaraldi T, Henry R, Dohm L, Flier JS, O'Rahilly S, Vidal-Puig AJ. | 01/21/2010 |