| The results suggest that certain forms of MMP-9 are released and accumulate in the extracellular space after brain injury, and that vascular alterations and neutrophil recruitment elicit MMP-9 activation in the brain after focal ischemia and trauma. | Certain forms of matrix metalloproteinase-9 accumulate in the extracellular space after microdialysis probe implantation and middle cerebral artery occlusion/reperfusion.
Planas AM, Justicia C, Solé S, Friguls B, Cervera A, Adell A, Chamorro A. | 01/21/2010 |
| Recombinaant human erythropoietin-activated endothelial cells enhance neural progenitor cell migration by secreting MMP2 and MMP9. | Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration.
Wang L, Zhang ZG, Zhang RL, Gregg SR, Hozeska-Solgot A, LeTourneau Y, Wang Y, Chopp M., Free PMC Article | 01/21/2010 |
| increases in gelatinase B activity accompanied the progression of neuronal death and glial reactivity. | Gelatinase B and TIMP-1 are regulated in a cell- and time-dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia.
Rivera S, Ogier C, Jourquin J, Timsit S, Szklarczyk AW, Miller K, Gearing AJ, Kaczmarek L, Khrestchatisky M. | 01/21/2010 |
| modulation of MMP9 expression by PPARalpha agonists is indirect and due to a NO-mediated reduction of mRNA stability | Inhibition of cytokine-induced matrix metalloproteinase 9 expression by peroxisome proliferator-activated receptor alpha agonists is indirect and due to a NO-mediated reduction of mRNA stability.
Eberhardt W, Akool el-S, Rebhan J, Frank S, Beck KF, Franzen R, Hamada FM, Pfeilschifter J. | 01/21/2010 |
| the amplification of MMP-9 expression by extracellular ATP is triggered through mechanisms that likely involve a HuR-dependent rise in MMP-9 mRNA stability. | ATP potentiates interleukin-1 beta-induced MMP-9 expression in mesangial cells via recruitment of the ELAV protein HuR.
Huwiler A, Akool el-S, Aschrafi A, Hamada FM, Pfeilschifter J, Eberhardt W. | 01/21/2010 |
| inhibition of ERK1/2 and JNKs inhibits IL-1beta-stimulated increases in MMP-9, not MMP-2, expression and activity. | Differential regulation of matrix metalloproteinase-2 and -9 expression and activity in adult rat cardiac fibroblasts in response to interleukin-1beta.
Xie Z, Singh M, Singh K. | 01/21/2010 |
| Temperospatial expression of matrix metalloproteinases 1, 2, 3, and 9 during early tooth development. | Temperospatial expression of matrix metalloproteinases 1, 2, 3, and 9 during early tooth development.
Randall LE, Hall RC. | 01/21/2010 |
| Enhancement of MMP9 gene expression & activity preceded LV dilatation in the hypertensive HF model & progressed with LV geometrical & functional deterioration. MMP9 is likely to trigger LV remodeling & to promote it. | Activation of matrix metalloproteinases precedes left ventricular remodeling in hypertensive heart failure rats: its inhibition as a primary effect of Angiotensin-converting enzyme inhibitor.
Sakata Y, Yamamoto K, Mano T, Nishikawa N, Yoshida J, Hori M, Miwa T, Masuyama T. | 01/21/2010 |
| study strongly supports that the perturbation of decreased tissue inhibitor of metalloproteinase 1 (TIMP-1) and increased matrix metalloproteinase-9(MMP-9) contributes to the pathogenesis of brain edema in fulminant hepatic failure | TIMP-1/MMP-9 imbalance in brain edema in rats with fulminant hepatic failure.
Yamamoto S, Nguyen JH., Free PMC Article | 01/21/2010 |
| Role for MMP-9 in hippocampal synaptic physiology, plasticity, and memory. | Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory.
Nagy V, Bozdagi O, Matynia A, Balcerzyk M, Okulski P, Dzwonek J, Costa RM, Silva AJ, Kaczmarek L, Huntley GW., Free PMC Article | 01/21/2010 |
| SMC-produced NGAL interacts with MMP-9, a mechanism by which NGAL may modulate MMP-9 proteolytic activity in the vascular repair process. | Induction of neutrophil gelatinase-associated lipocalin in vascular injury via activation of nuclear factor-kappaB.
Bu DX, Hemdahl AL, Gabrielsen A, Fuxe J, Zhu C, Eriksson P, Yan ZQ., Free PMC Article | 01/21/2010 |
| important role of MMP-2, MMP-9, and TIMP-4 in hypertensive remodeling of the cortex and medulla in the SHR rat | Mechanism of matrix accumulation and glomerulosclerosis in spontaneously hypertensive rats.
Camp TM, Smiley LM, Hayden MR, Tyagi SC. | 01/21/2010 |
| MMP-9 plays an important role in the remodelling of extracellular matrix in various renal diseases. | Expression of matrix metalloproteinase-9 associated with ets-1 proto-oncogene in rat tubulointerstitial cells.
Naito T, Tanihata Y, Nishimura H, Tanaka T, Higuchi C, Taguchi T, Sanaka T. | 01/21/2010 |
| findings suggest a potential extracellular proteolysis pathway to neuronal cell death in which S-nitrosylation activates MMPs, and further oxidation results in a stable posttranslational modification with pathological activity | S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death.
Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, Smith JW, Liddington RC, Lipton SA. | 01/21/2010 |
| These results demonstrate that NO acts in a cGMP-dependent mechanism to inhibit the expression level of HuR, thereby reducing the stability of MMP-9 mRNA. | Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR.
Akool el-S, Kleinert H, Hamada FM, Abdelwahab MH, Förstermann U, Pfeilschifter J, Eberhardt W., Free PMC Article | 01/21/2010 |
| MMP-9 regulates neurite extension in regenerating peripheral nerve fibers and, therefore, might be of therapeutic value in promoting regeneration in vivo. | Matrix metalloproteinase-9 promotes nerve growth factor-induced neurite elongation but not new sprout formation in vitro.
Shubayev VI, Myers RR. | 01/21/2010 |
| tPA upregulates brain MMP-9 levels in stroke in vivo | Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia.
Tsuji K, Aoki T, Tejima E, Arai K, Lee SR, Atochin DN, Huang PL, Wang X, Montaner J, Lo EH. | 01/21/2010 |
| Induction of colitis led to a significant upregulation of matrix metalloproteinase-9 protein and its activity | Increased activity and expression of matrix metalloproteinase-9 in a rat model of distal colitis.
Medina C, Videla S, Radomski A, Radomski MW, Antolín M, Guarner F, Vilaseca J, Salas A, Malagelada JR. | 01/21/2010 |
| Perindopril reduced levels of this enzyme in carbon tetrachloride-induece hepatic fibrogenesis. | ACEI attenuates the progression of CCl4-induced rat hepatic fibrogenesis by inhibiting TGF-beta1, PDGF-BB, NF-kappaB and MMP-2,9.
Li X, Meng Y, Yang XS, Mi LF, Cai SX., Free PMC Article | 01/21/2010 |
| In contrast to chronic recombinant relaxin administration, MMP-9 rather than MMP-2 plays a central role in the vasodilatory effect of short-term relaxin administration | Vascular matrix metalloproteinase-9 mediates the inhibition of myogenic reactivity in small arteries isolated from rats after short-term administration of relaxin.
Jeyabalan A, Novak J, Doty KD, Matthews J, Fisher MC, Kerchner LJ, Conrad KP. | 01/21/2010 |
| findings causally link MMPs to trauma-induced neuronal cell death in the immature rodent brain | The role of matrix metalloproteinases in infant traumatic brain injury.
Sifringer M, Stefovska V, Zentner I, Hansen B, Stepulak A, Knaute C, Marzahn J, Ikonomidou C. | 01/21/2010 |
| inhibition of MMP9 expression by PDGF-PI3k pathway | Induced expression of MMP-9 in C6 glioma cells is inhibited by PDGF via a PI 3-kinase-dependent pathway.
Estève PO, Robledo O, Potworowski EF, St-Pierre Y. | 01/21/2010 |
| MMP9 is activated through an oxidative pathway in pneumococcal meningitis | Matrix metalloproteinase-9 in pneumococcal meningitis: activation via an oxidative pathway.
Meli DN, Christen S, Leib SL. | 01/21/2010 |
| These findings suggest that the contribution of MMP-9 upregulation to the inflammatory and degenerative changes that follow nerve injury is independent of mast cell activation. | Upregulation of matrix metalloproteinases following nerve injury is not mediated by mast cell activation.
Zuo YX, Tracey DJ, Geczy C. | 01/21/2010 |
| tPA acts as a cytokine that binds to the cell membrane receptor LRP-1, induces its tyrosine phosphorylation, and triggers intracellular signal transduction to induce MMP9 gene expression | Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression.
Hu K, Yang J, Tanaka S, Gonias SL, Mars WM, Liu Y. | 01/21/2010 |