| AGR2 has a role as a stem cell marker that is highly regulated by canonical Wnt and beta-catenin signaling in colorectal cancer | AGR2 is a target of canonical Wnt/β-catenin signaling and is important for stemness maintenance in colorectal cancer stem cells.
Dahal Lamichane B, Jung SY, Yun J, Kang S, Kim DY, Lamichane S, Kim YJ, Park JH, Jang WB, Ji ST, Dehua L, Ha JS, Kim YH, Kwon SM. | 07/11/2020 |
| With specific shRNA transduction, AGR2 was shown to be a key factor in MUC5AC hypersecretion in vitro in immortalized brochial epithelial cells. During hypoxia-induced MUC5AC hypersecretion in vitro there was increased binding and intracytoplasmic colocation of HIF-1alpha and AGR2. | The role of the XBP-1/AGR2 signaling pathway in the regulation of airway Mucin5ac hypersecretion under hypoxia.
Xu R, Zhou J, Du XZ, Zhou XD, Li Q, Perelman JM, Kolosov VP. | 06/27/2020 |
| DNMT3a-mediated epigenetic modulation on AGR2 promoter. | AGR2 is controlled by DNMT3a-centered signaling module and mediates tumor resistance to 5-Aza in colorectal cancer.
Li J, Hu J, Luo Z, Zhou C, Huang L, Zhang H, Chi J, Chen Z, Li Q, Deng M, Chen J, Tao K, Wang G, Wang L, Wang Z. | 06/20/2020 |
| Our findings uncover a key role of LINC02273-hnRNPL-AGR2 axis in breast cancer metastasis and provide potential novel therapeutic targets for metastatic breast cancer intervention. | LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription.
Xiu B, Chi Y, Liu L, Chi W, Zhang Q, Chen J, Guo R, Si J, Li L, Xue J, Shao ZM, Wu ZH, Huang S, Wu J., Free PMC Article | 06/6/2020 |
| AGR2 was highly expressed in pancreatic cancer. AGR2 was found to be a target gene of miR-143. | Long non-coding RNA LINC01207 silencing suppresses AGR2 expression to facilitate autophagy and apoptosis of pancreatic cancer cells by sponging miR-143-5p.
Liu C, Wang JO, Zhou WY, Chang XY, Zhang MM, Zhang Y, Yang XH. | 05/23/2020 |
| study demonstrates that AGR2 dimers act as sensors of ER homeostasis which are disrupted upon ER stress and promote the secretion of AGR2 monomers. | Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.
Maurel M, Obacz J, Avril T, Ding YP, Papadodima O, Treton X, Daniel F, Pilalis E, Hörberg J, Hou W, Beauchamp MC, Tourneur-Marsille J, Cazals-Hatem D, Sommerova L, Samali A, Tavernier J, Hrstka R, Dupont A, Fessart D, Delom F, Fernandez-Zapico ME, Jansen G, Eriksson LA, Thomas DY, Jerome-Majewska L, Hupp T, Chatziioannou A, Chevet E, Ogier-Denis E., Free PMC Article | 04/25/2020 |
| Modulation of overexpression of AGR2 in mutant non-small cell lung cancer cells may be an attractive therapeutic strategy for the treatment of EGFR-TKI-resistant non-small cell lung cancer. | Overexpression of AGR2 Is Associated With Drug Resistance in Mutant Non-small Cell Lung Cancers.
Luu TT, Bach DH, Kim D, Hu R, Park HJ, Lee SK. | 04/11/2020 |
| RAD9A drives metastasis by controlling AGR2 abundance. | RAD9A promotes metastatic phenotypes through transcriptional regulation of anterior gradient 2 (AGR2).
Broustas CG, Hopkins KM, Panigrahi SK, Wang L, Virk RK, Lieberman HB., Free PMC Article | 11/9/2019 |
| Excluding breast cancer, AGR2 overexpression was found to have a significant correlation with poor overall survival in other solid tumor patients. | The prognostic value of AGR2 expression in solid tumours: a systematic review and meta-analysis.
Tian SB, Tao KX, Hu J, Liu ZB, Ding XL, Chu YN, Cui JY, Shuai XM, Gao JB, Cai KL, Wang JL, Wang GB, Wang L, Wang Z., Free PMC Article | 07/13/2019 |
| Downregulation of AGR2 by proteasome inhibition significantly enhanced antitumor activity of bevacizumab. | Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab.
Wang D, Xu Q, Yuan Q, Jia M, Niu H, Liu X, Zhang J, Young CY, Yuan H., Free PMC Article | 05/25/2019 |
| Localization of AGR2 also has opposing effects on the Hippo pathway. | Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.
Tiemann K, Garri C, Lee SB, Malihi PD, Park M, Alvarez RM, Yap LP, Mallick P, Katz JE, Gross ME, Kani K., Free PMC Article | 05/4/2019 |
| AGR2 increased in TKI-resistant CML cells and its silencing restored sensitivity. Dasatinib upregulated it in K562 cells.miR-217 negatively regulated expression of AGR2 through binding its 3'-UTR. TKI treatment-induced drug resistance is correlated with a decrease of miR-217 and upregulation of AGR2. Forced expression of miR-217 led to decreased expression of AGR2. | miR-217 sensitizes chronic myelogenous leukemia cells to tyrosine kinase inhibitors by targeting pro-oncogenic anterior gradient 2.
Pan B, Yang J, Wang X, Xu K, Ikezoe T. | 04/27/2019 |
| Our results highlight the potential of miR-135b-5p as a target for treating AGR2-expressing breast cancer with doxorubicin-resistance. | miR-135b-5p enhances doxorubicin-sensitivity of breast cancer cells through targeting anterior gradient 2.
Zhang Y, Xia F, Zhang F, Cui Y, Wang Q, Liu H, Wu Y., Free PMC Article | 04/20/2019 |
| aberrant alternative splicing of AGR2 facilitates an accumulation of the oncogenic AGR2vH isoform, in turn, contributes to the pathogenesis and severity of Cholangiocarcinoma. | An aberrantly spliced isoform of anterior gradient-2, AGR2vH promotes migration and invasion of cholangiocarcinoma cell.
Yosudjai J, Inpad C, Chomwong S, Dana P, Sawanyawisuth K, Phimsen S, Wongkham S, Jirawatnotai S, Kaewkong W. | 01/26/2019 |
| The secreted AGR2 may be a potential therapeutic target towards inhibiting CRC metastasis. | Secreted AGR2 promotes invasion of colorectal cancer cells via Wnt11-mediated non-canonical Wnt signaling.
Tian S, Hu J, Tao K, Wang J, Chu Y, Li J, Liu Z, Ding X, Xu L, Li Q, Cai M, Gao J, Shuai X, Wang G, Wang L, Wang Z. | 01/12/2019 |
| AGR2 silencing could promote cell apoptosis and inhibit cell migration, invasion and chemotherapy resistance of pancreatic cancer cells with the involvement of the ERK/AKT axis | Knockdown of AGR2 induces cell apoptosis and reduces chemotherapy resistance of pancreatic cancer cells with the involvement of ERK/AKT axis.
Liu QG, Li YJ, Yao L. | 12/22/2018 |
| Serum AGR2 can be used as a serum marker for clinical prognosis of nasopharyngeal carcinoma. However, serum AGR2 levels could not provide advantages in clinical practice for the differential diagnosis of cancer. | AGR2 diagnostic value in nasopharyngeal carcinoma prognosis.
Li Y, Wang W, Liu Z, Jiang Y, Lu J, Xie H, Tang F. | 11/17/2018 |
| The results suggest that MUC13 overexpression and loss of expression of AGR2 may predict the progression of Intraductal papillary mucinous neoplasm and an unfavorable prognosis in patients with Intraductal papillary mucinous neoplasm | Clinicopathological and prognostic significance of MUC13 and AGR2 expression in intraductal papillary mucinous neoplasms of the pancreas.
Mito K, Saito M, Morita K, Maetani I, Sata N, Mieno M, Fukushima N. | 11/10/2018 |
| Cytosolic AGR2 contributed to cell metastasis ascribed to its stabilizing effect on p65 protein, which subsequently activated the NF-kappaB and facilitated epithelial to mesenchymal transition (EMT). | Pro-metastatic activity of AGR2 interrupts angiogenesis target bevacizumab efficiency via direct interaction with VEGFA and activation of NF-κB pathway.
Jia M, Guo Y, Zhu D, Zhang N, Li L, Jiang J, Dong Y, Xu Q, Zhang X, Wang M, Yu H, Wang F, Tian K, Zhang J, Young CYF, Lou H, Yuan H. | 07/14/2018 |
| Our data confirm AGR2 as a keeper of epithelial phenotypes, showing a positive role of AGR2 in the regulation of the epithelial marker E-cadherin and a negative effect on the mesenchymal markers vimentin and N-cadherin. | Suppression of AGR2 in a TGF-β-induced Smad regulatory pathway mediates epithelial-mesenchymal transition.
Sommerova L, Ondrouskova E, Vojtesek B, Hrstka R., Free PMC Article | 05/5/2018 |
| Authors demonstrated that inhibition of either FOXM1 or AGR2 in human PIMAs inhibited mucinous characteristics, and reduced tumor growth and invasion. FOXM1 is necessary and sufficient to induce mucinous phenotypes in lung tumor cells in vivo. | FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas.
Milewski D, Balli D, Ustiyan V, Le T, Dienemann H, Warth A, Breuhahn K, Whitsett JA, Kalinichenko VV, Kalin TV., Free PMC Article | 03/3/2018 |
| AGR2 is secreted by prostate cancer cells and induces programmed cell death in normal cells | Cancer-secreted AGR2 induces programmed cell death in normal cells.
Vitello EA, Quek SI, Kincaid H, Fuchs T, Crichton DJ, Troisch P, Liu AY., Free PMC Article | 02/24/2018 |
| secretion and cell surface localization of AGR2 are characteristic of bladder cancer, while expression of AGR2 by itself is not. | Bladder cancer cells secrete while normal bladder cells express but do not secrete AGR2.
Ho ME, Quek SI, True LD, Seiler R, Fleischmann A, Bagryanova L, Kim SR, Chia D, Goodglick L, Shimizu Y, Rosser CJ, Gao Y, Liu AY., Free PMC Article | 12/16/2017 |
| Obesity induces the expression of the mitochondrial form of arginase ARG2 in pancreatic ductal adenocarcinoma. | Critical role for arginase 2 in obesity-associated pancreatic cancer.
Zaytouni T, Tsai PY, Hitchcock DS, DuBois CD, Freinkman E, Lin L, Morales-Oyarvide V, Lenehan PJ, Wolpin BM, Mino-Kenudson M, Torres EM, Stylopoulos N, Clish CB, Kalaany NY., Free PMC Article | 12/16/2017 |
| Overexpression of AGR2 counteracts the phenotypes induced by miR-342-3p. | miR-342-3p suppresses cell proliferation and migration by targeting AGR2 in non-small cell lung cancer.
Xue X, Fei X, Hou W, Zhang Y, Liu L, Hu R. | 12/9/2017 |