| Activation of macrophages by lipopolysaccharide induced down-regulation of the expression of adenosine receptor A3 mrna. | Adenosine A(1), A(2a), A(2b), and A(3) receptors in hematopoiesis. 2. Expression of receptor mRNA in resting and lipopolysaccharide-activated mouse RAW 264.7 macrophages.
Štreitová D, Hofer M, Holá J, Vacek A, Pospíšil M. | 08/30/2010 |
| activation of the A(3)AR signals to suppress neutrophil functions by interfering with the monomeric GTPase Rac, thus contributing to the ant-inflammatory actions of adenosine. | Activation of the A(3) adenosine receptor inhibits fMLP-induced Rac activation in mouse bone marrow neutrophils.
van der Hoeven D, Gizewski ET, Auchampach JA., Free PMC Article | 05/31/2010 |
| Activation of adenosine receptor type 3 inhibits long term potentiation in the hippocampus. | LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R).
Maggi L, Trettel F, Scianni M, Bertollini C, Eusebi F, Fredholm BB, Limatola C. | 01/21/2010 |
| evidence of a significant role of selective activation of adenosine A(3) receptors in stimulation of the growth of granulocyte/ macrophage hematopoietic progenitor cells | Activation of adenosine A(3) receptors potentiates stimulatory effects of IL-3, SCF, and GM-CSF on mouse granulocyte-macrophage hematopoietic progenitor cells.
Hofer M, Vacek A, Pospíšil M, Holá J, Štreitová D, Znojil V. | 01/21/2010 |
| Adult male mice carrying a genetic deletion of A3 receptors differ from the wild type male mice in that the overall locomotor activity was higher; unexpectedly, caffeine responses were reduced in the mice lacking A3 receptors. | Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice.
Björklund O, Halldner-Henriksson L, Yang J, Eriksson TM, Jacobson MA, Daré E, Fredholm BB. | 01/21/2010 |
| These results suggest that the A(3)R serves antiinflammatory functions in the bleomycin model, and is also involved in regulating the production of mediators that can impact fibrosis. | A3 adenosine receptor signaling influences pulmonary inflammation and fibrosis.
Morschl E, Molina JG, Volmer JB, Mohsenin A, Pero RS, Hong JS, Kheradmand F, Lee JJ, Blackburn MR., Free PMC Article | 01/21/2010 |
| Adenosine 3 receptor knockout attenuates transverse aortic constriction-induced left ventricular hypertrophy, fibrosis, oxidative stress, and dysfunction. | Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle.
Lu Z, Fassett J, Xu X, Hu X, Zhu G, French J, Zhang P, Schnermann J, Bache RJ, Chen Y., Free PMC Article | 01/21/2010 |
| Involved in the influx of neutrophils into the lungs after sepsis. | A3 and P2Y2 receptors control the recruitment of neutrophils to the lungs in a mouse model of sepsis.
Inoue Y, Chen Y, Hirsh MI, Yip L, Junger WG., Free PMC Article | 01/21/2010 |
| The A(3)AR contributes to the anti-inflammatory actions of adenosine on neutrophils. | Activation of the A(3) adenosine receptor suppresses superoxide production and chemotaxis of mouse bone marrow neutrophils.
van der Hoeven D, Wan TC, Auchampach JA., Free PMC Article | 01/21/2010 |
| it is concluded that adenosine induces airway hyperresponsiveness indirectly by activating A(3) receptors on mast cells | Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells.
Hua X, Chason KD, Fredholm BB, Deshpande DA, Penn RB, Tilley SL., Free PMC Article | 01/21/2010 |
| The results indicate opposite effects of the two adenosine receptor agonists on proliferation of hematopoietic cells and suggest the plasticity and homeostatic role of the adenosine A3 and A1 receptors expression. | Homeostatic action of adenosine A3 and A1 receptor agonists on proliferation of hematopoietic precursor cells.
Hofer M, Pospísil M, Znojil V, Holá J, Streitová D, Vacek A. | 01/21/2010 |
| Demonstrate for the first time the involvement of COX-1 pathway in A(3)AR-mediated contraction via endothelium. | Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta.
Ansari HR, Nadeem A, Tilley SL, Mustafa SJ. | 01/21/2010 |
| The adenosine A(3) receptor is a novel cytoprotective receptor that signals selectively via phospholipase C-beta and represents a new target for ameliorating skeletal muscle ischemic injury. | Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury.
Zheng J, Wang R, Zambraski E, Wu D, Jacobson KA, Liang BT., Free PMC Article | 01/21/2010 |
| Activation of the A3 adenosine receptor by a mechanism that involves opening the sarcolemmal ATP-sensitive potassium channel exerts a protective effect on the ischemic myocardium. | The A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel.
Wan TC, Ge ZD, Tampo A, Mio Y, Bienengraeber MW, Tracey WR, Gross GJ, Kwok WM, Auchampach JA., Free PMC Article | 01/21/2010 |
| increase of cell proliferation after adenosine A(3) receptor agonist IB-MECA treatment irrespective of the cell lineage investigated | Adenosine A(3) receptor agonist acts as a homeostatic regulator of bone marrow hematopoiesis.
Hofer M, Pospísil M, Znojil V, Holá J, Vacek A, Streitová D. | 01/21/2010 |
| the presence of adenosine A(3) receptors may either inhibit or negatively modulate coronary flow mediated by other adenosine receptor subtypes | Targeted deletion of adenosine A(3) receptors augments adenosine-induced coronary flow in isolated mouse heart.
Talukder MA, Morrison RR, Jacobson MA, Jacobson KA, Ledent C, Mustafa SJ., Free PMC Article | 01/21/2010 |
| Late preconditioning elicited by activation of adenosine A(3) receptor in heart: role of NF- kappa B, iNOS and mitochondrial K(ATP) channel | Late preconditioning elicited by activation of adenosine A(3) receptor in heart: role of NF- kappa B, iNOS and mitochondrial K(ATP) channel.
Zhao TC, Kukreja RC. | 01/21/2010 |
| Stimulation of adenosine A3 receptors in astrocytes induced the release of CCL2; adenosine receptors in glial cells regulate the synthesis of neuroprotective substances. | Adenosine A3 receptor-induced CCL2 synthesis in cultured mouse astrocytes.
Wittendorp MC, Boddeke HW, Biber K. | 01/21/2010 |
| endogenous or exogenous A3AR activation confers significant protection from murine septic peritonitis primarily by attenuating the hyperacute inflammatory response in sepsis | A3 adenosine receptor activation decreases mortality and renal and hepatic injury in murine septic peritonitis.
Lee HT, Kim M, Joo JD, Gallos G, Chen JF, Emala CW. | 01/21/2010 |
| Analysis of activity and expression of A3 adenosine receptor promoter gene in transgenic mice | Activity of the A3 adenosine receptor gene promoter in transgenic mice: characterization of previously unidentified sites of expression.
Yaar R, Lamperti ED, Toselli PA, Ravid K. | 01/21/2010 |
| A3R is essential for inosine-mediated protection against ConA-induced fulminant hepatitis. A3 receptors are also utilized by inosine for the down-regulation of tissue damage in a model of LPS-induced endotoxemia. | Differential requirement for A2a and A3 adenosine receptors for the protective effect of inosine in vivo.
Gomez G, Sitkovsky MV. | 01/21/2010 |
| Overexpression of A(3) adenosine receptors decreases heart rate, preserves energetics, and protects ischemic hearts. | Overexpression of A(3) adenosine receptors decreases heart rate, preserves energetics, and protects ischemic hearts.
Cross HR, Murphy E, Black RG, Auchampach J, Steenbergen C., Free PMC Article | 01/21/2010 |
| Results suggest that the A(3)adenosine receptor contributes to mucin secretion in allergen-induced metaplasia. | A3 adenosine receptor signaling contributes to airway mucin secretion after allergen challenge.
Young HW, Sun CX, Evans CM, Dickey BF, Blackburn MR., Free PMC Article | 01/21/2010 |
| A3ARs are critically involved in the inflammatory response and are probably not physiologically involved in modulating nociception. | Decreased inflammatory pain due to reduced carrageenan-induced inflammation in mice lacking adenosine A3 receptors.
Wu WP, Hao JX, Halldner-Henriksson L, Xu XJ, Jacobson MA, Wiesenfeld-Hallin Z, Fredholm BB. | 01/21/2010 |
| These data affirm the cardioprotective role of A(1)ARs and suggest that induced expression of other adenosine receptor subtypes [A(2A), A(2B), and A(3)] may participate in the response to ischemia-reperfusion in isolated murine hearts. | Effects of targeted deletion of A1 adenosine receptors on postischemic cardiac function and expression of adenosine receptor subtypes.
Morrison RR, Teng B, Oldenburg PJ, Katwa LC, Schnermann JB, Mustafa SJ. | 01/21/2010 |