| Study provides evidence that high expression levels of CCR5, CCR6 and CCR9 are associated with prolonged overall survival in patients with earlystage pancreatic ductal adenocarcinoma (PDAC). Collectively, this highlights that CCR5, CCR6 and CCR9 are potential prognostic biomarkers for earlystage PDAC. | Clinical significance and prospective molecular mechanism of C‑C motif chemokine receptors in patients with early‑stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy.
Zhou X, Liao X, Wang X, Huang K, Yang C, Yu T, Liu J, Han C, Zhu G, Su H, Qin W, Han Q, Liu Z, Huang J, Gong Y, Ye X, Peng T., Free PMC Article | 02/29/2020 |
| High CCR6 expression is associated with hepatocellular carcinoma cell proliferation, invasion and angiogenesis. | DEPDC1 drives hepatocellular carcinoma cell proliferation, invasion and angiogenesis by regulating the CCL20/CCR6 signaling pathway.
Guo W, Li H, Liu H, Ma X, Yang S, Wang Z., Free PMC Article | 01/25/2020 |
| we identified HCV-induced CCL20 as a direct pro-angiogenic factor that acts on endothelial CCR6. These results suggest that the CCL20/CCR6 axis contributes to hepatic angiogenesis, promoting the hypervascular state of hepatitis C virus (HCV)-hepatocellular carcinoma (HCC). | CCL20, a direct-acting pro-angiogenic chemokine induced by hepatitis C virus (HCV): Potential role in HCV-related liver cancer.
Benkheil M, Van Haele M, Roskams T, Laporte M, Noppen S, Abbasi K, Delang L, Neyts J, Liekens S. | 09/21/2019 |
| this study shows that the effects of site-specific Ser/Thr phosphorylation on CCR6 demonstrate the existence of barcodes on the protein that dictate the activation of different cell signaling profiles and lead to distinct biological outcomes | The Phosphorylation of CCR6 on Distinct Ser/Thr Residues in the Carboxyl Terminus Differentially Regulates Biological Function.
Lu MY, Lu SS, Chang SL, Liao F., Free PMC Article | 06/29/2019 |
| In gastric infiltrating lymphocytes, CCR6(+ ) CD4(+ ) CD25(high) Tregs, which express high levels of CD45RO, are positively associated with more severe inflammation in gastric mucosa during H. pylori infection. The frequency of CCR6(+) Tregs is positively correlated with the frequency of CD4(+ ) IFN-gamma(+) T cells while is inversely correlated with lower expression of IFN-gamma(+ ) CD8(+) T cells. | Recruitment of CCR6(+ ) Foxp3(+) regulatory gastric infiltrating lymphocytes in Helicobacter pylori gastritis.
Wu YY, Hsieh CT, Tsay GJ, Kao JT, Chiu YM, Shieh DC, Lee YJ. | 04/27/2019 |
| this study shows that CCR6 signaling inhibits suppressor function of induced-Treg during gut inflammation | CCR6 signaling inhibits suppressor function of induced-Treg during gut inflammation.
Kulkarni N, Meitei HT, Sonar SA, Sharma PK, Mujeeb VR, Srivastava S, Boppana R, Lal G. | 04/13/2019 |
| CCR6 expression and its role in glioblastoma under hypoxic conditions. | Astrocyte-derived CCL20 reinforces HIF-1-mediated hypoxic responses in glioblastoma by stimulating the CCR6-NF-κB signaling pathway.
Jin P, Shin SH, Chun YS, Shin HW, Shin YJ, Lee Y, Kim D, Nam DH, Park JW. | 03/9/2019 |
| The populations were identified based on the production of IFN-gamma and/or IL-17 and the coexpression of CXCR3 (X3) and CCR6 (R6). | Th1, Th17, and Th1Th17 Lymphocytes during Tuberculosis: Th1 Lymphocytes Predominate and Appear as Low-Differentiated CXCR3(+)CCR6(+) Cells in the Blood and Highly Differentiated CXCR3(+/-)CCR6(-) Cells in the Lungs.
Nikitina IY, Panteleev AV, Kosmiadi GA, Serdyuk YV, Nenasheva TA, Nikolaev AA, Gorelova LA, Radaeva TV, Kiseleva YY, Bozhenko VK, Lyadova IV. | 02/23/2019 |
| Study demonstrated that CCR6 overexpression contributed to a poor radiotherapy effect in rectal cancer (RC) patients and radioresistance in CRC cell lines. Also the results implied that the CCR6 might enhance radioresistance through more effective DNA damage repair. | CCR6 Is a Predicting Biomarker of Radiosensitivity and Potential Target of Radiosensitization in Rectal Cancer.
Chang H, Wei JW, Tao YL, Ding PR, Xia YF, Gao YH, Xiao WW., Free PMC Article | 01/19/2019 |
| Identified a population of gut-derived TREG cells producing CCR6 and CXCR6 which are significantly reduced in inflammatory bowel disease. | Expression of CCR6 and CXCR6 by Gut-Derived CD4(+)/CD8α(+) T-Regulatory Cells, Which Are Decreased in Blood Samples From Patients With Inflammatory Bowel Diseases.
Godefroy E, Alameddine J, Montassier E, Mathé J, Desfrançois-Noël J, Marec N, Bossard C, Jarry A, Bridonneau C, Le Roy A, Sarrabayrouse G, Kerdreux E, Bourreille A, Sokol H, Jotereau F, Altare F. | 10/27/2018 |
| CCR6 facilitates tumor angiogenesis via the AKT/NF-kappaB/VEGF pathway in colorectal cancer | CCR6 promotes tumor angiogenesis via the AKT/NF-κB/VEGF pathway in colorectal cancer.
Zhu CC, Chen C, Xu ZQ, Zhao JK, Ou BC, Sun J, Zheng MH, Zong YP, Lu AG. | 05/26/2018 |
| expression increased on B cells of systemic lupus erythematosus patients | Expression of CCR6 on B cells in systemic lupus erythematosus patients.
Lee AYS, Bannan JL, Adams MJ, Körner H. | 03/24/2018 |
| In conclusion, it seems that decreased expression of CXCR3 and higher expression of CCR6 were associated with HTLV-1 infection, what indicate that these alterations may favor virus dissemination but not disease manifestation. | Altered expression of CXCR3 and CCR6 and their ligands in HTLV-1 carriers and HAM/TSP patients.
Rafatpanah H, Felegari M, Azarpazhooh MR, Vakili R, Rajaei T, Hampson I, Hassanshahi G, Valizadeh N, Gerayli S, Hamid F, Zamanian S, MollaHosseini F, Rezaee SA. | 02/3/2018 |
| Bin1-N-BAR domains assemble into scaffolds of low long-range order that form flexible membrane tubule in the sarcolemma | Supramolecular organization of the human N-BAR domain in shaping the sarcolemma membrane.
Daum B, Auerswald A, Gruber T, Hause G, Balbach J, Kühlbrandt W, Meister A. | 01/6/2018 |
| CCR6 defines memory B cell precursors in mouse and human germinal centers, revealing light-zone location and predominant low antigen affinity. | CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity.
Suan D, Kräutler NJ, Maag JLV, Butt D, Bourne K, Hermes JR, Avery DT, Young C, Statham A, Elliott M, Dinger ME, Basten A, Tangye SG, Brink R. | 12/30/2017 |
| High expression of CCR6 is associated with cutaneous T-cell lymphoma. | Disruption of CCL20-CCR6 interaction inhibits metastasis of advanced cutaneous T-cell lymphoma.
Ikeda S, Kitadate A, Ito M, Abe F, Nara M, Watanabe A, Takahashi N, Miyagaki T, Sugaya M, Tagawa H., Free PMC Article | 12/23/2017 |
| CCR6(-) regulatory T cells blunt the restoration of gut Th17 cells along the CCR6-CCL20 axis in treated HIV-1-infected patients. | CCR6(-) regulatory T cells blunt the restoration of gut Th17 cells along the CCR6-CCL20 axis in treated HIV-1-infected individuals.
Loiseau C, Requena M, Mavigner M, Cazabat M, Carrere N, Suc B, Barange K, Alric L, Marchou B, Massip P, Izopet J, Delobel P. | 10/28/2017 |
| results provide a potential explanation for involvement of the CCL20-CCR6 system in the trafficking of IL-17-producing cells to degenerated IVD tissues | CCL20 Secretion from the Nucleus Pulposus Improves the Recruitment of CCR6-Expressing Th17 Cells to Degenerated IVD Tissues.
Zhang W, Nie L, Wang Y, Wang XP, Zhao H, Dongol S, Maharjan S, Cheng L., Free PMC Article | 10/14/2017 |
| The percentage of CXCR3(+) CD4(+) TEM cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA(+) CD4(+) TCM cells expressing CCR6(+) or CCR4(+)CXCR3(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment. | Blood to skin recirculation of CD4(+) memory T cells associates with cutaneous and systemic manifestations of psoriatic disease.
Diani M, Galasso M, Cozzi C, Sgambelluri F, Altomare A, Cigni C, Frigerio E, Drago L, Volinia S, Granucci F, Altomare G, Reali E. | 09/2/2017 |
| High CCR6 expression is associated with B-lymphoblastic lymphoma with inflammation. | STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner.
Tsuruyama T, Hiratsuka T, Aini W, Nakamura T. | 08/19/2017 |
| CCR6 expression was higher in cells derived from node-positive cases and highest expression was in cells derived from metastatic cases of colon cancer. | CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition.
Kapur N, Mir H, Clark Iii CE, Krishnamurti U, Beech DJ, Lillard JW, Singh S., Free PMC Article | 06/24/2017 |
| The study suggests that a genetic interaction between DPP4 and CCR6 is involved in RA susceptibility | Evidence of epistatic interaction between DPP4 and CCR6 in patients with rheumatoid arthritis.
Leng RX, Liu J, Yang XK, Wang B, Zhang C, Tao SS, Wang DG, Li XM, Li XP, Pan HF, Ye DQ. | 05/27/2017 |
| point mutations in CCR6 can result in either a gain or loss of receptor function | Mutation-Induced Functional Alterations of CCR6.
Julian B, Gao K, Harwood BN, Beinborn M, Kopin AS. | 05/27/2017 |
| Rheumatoid arthritis-associated double nucleotide polymorphism in CCR6 regulates CCR6 via PARP-1. | The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1.
Li G, Cunin P, Wu D, Diogo D, Yang Y, Okada Y, Plenge RM, Nigrovic PA., Free PMC Article | 05/13/2017 |
| This study evaluated the role of CCL20 and CCR6 in the regulation of laryngeal neoplasms; it showed that these proteins acted on proliferation and metastasis via the p38 pathway and multiple microRNAs. | CCL20/CCR6 promotes cell proliferation and metastasis in laryngeal cancer by activating p38 pathway.
Lu E, Su J, Zhou Y, Zhang C, Wang Y. | 02/25/2017 |